Thiabendazole

What is Thiabendazole

Thiabendazole is a broad-spectrum anthelmintic that is structurally related to mebendazole, and is one of the most potent anthelminthic drugs.

Thiabendazole is considered a first-line agent in the treatment of cutaneous larva migrans (creeping eruption) and strongyloidiasis (threadworm infection).

Although not considered a primary agent, thiabendazole is also indicated for treating other infections, such as enterobiasis (pinworm), toxocariasis (visceral larva migrans), uncinariasis (hookworm: Ancylostoma duodenale or Necator americanus), trichuriasis (whipworm), and ascariasis (roundworm), and for managing symptoms of invasive-stage trichinosis infection.

Thiabendazole should not be used to treat mixed infections with ascaris because it can cause the worms to migrate.

Because of the toxicity that may be associated with oral administration, topical application is currently the formulation of choice for the treatment of localized cutaneous larva migrans. Thiabendazole was approved by the FDA in 1967.

Brand Name

Mintezol

Indications

  1. Ancylostoma braziliense
  2. Ancylostoma caninum
  3. Ancylostoma duodenale
  4. Angiostrongylus cantonensis
  5. Angiostrongylus costaricensis
  6. anisakiasis
  7. ascariasis
  8. Ascaris lumbricoides
  9. Capillaria philippinensis
  10. capillariasis
  11. cutaneous larva migrans
  12. dracunculiasis
  13. Dracunculus medinensis
  14. enterobiasis (pinworm infection)
  15. Enterobius vermicularis
  16. Microsporum sp.
  17. Necator americanus
  18. Strongyloides stercoralis
  19. strongyloidiasis
  20. toxocariasis
  21. Trichinella spiralis
  22. trichinosis
  23. Trichophyton sp.
  24. trichostrongyliasis
  25. Trichostrongylus sp.
  26. trichuriasis
  27. Trichuris trichiura
  28. uncinariasis

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. angioedema
  4. anorexia
  5. azotemia
  6. blurred vision
  7. cholestasis
  8. confusion
  9. crystalluria
  10. diarrhea
  11. dizziness
  12. drowsiness
  13. elevated hepatic enzymes
  14. hallucinations
  15. headache
  16. hepatic failure
  17. hypotension
  18. irritability
  19. jaundice
  20. nausea
  21. ocular irritation
  22. pruritus
  23. seizures
  24. Stevens-Johnson syndrome
  25. tinnitus
  26. urticaria
  27. vomiting
  28. weakness
  29. xanthopsia
  30. xerophthalmia
  31. xerostomia

Monitoring Parameters

  • LFTs
  • pregnancy testing
  • serum creatinine/BUN
  • stool exam

Contraindications

  • anemia
  • breast-feeding
  • dehydration
  • driving or operating machinery
  • hepatic disease
  • pregnancy
  • renal impairment

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Alosetron
  • Anagrelide
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Bendamustine
  • Bupivacaine; Lidocaine
  • Caffeine
  • Caffeine; Ergotamine
  • Ciprofloxacin
  • Clozapine
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Eltrombopag
  • Fluoxetine; Olanzapine
  • Frovatriptan
  • Green Tea
  • Lidocaine
  • Lidocaine; Prilocaine
  • Melatonin
  • Mexiletine
  • Obeticholic Acid
  • Olanzapine
  • Pimozide
  • Pirfenidone
  • Pomalidomide
  • Ramelteon
  • Rasagiline
  • Riluzole
  • Ropinirole
  • Ropivacaine
  • Simeprevir
  • Tacrine
  • Tasimelteon
  • Terbinafine
  • Theophylline, Aminophylline
  • Tizanidine
  • Vemurafenib
  • Zileuton
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