What is Thiabendazole
Thiabendazole is a broad-spectrum anthelmintic that is structurally related to mebendazole, and is one of the most potent anthelminthic drugs.
Thiabendazole is considered a first-line agent in the treatment of cutaneous larva migrans (creeping eruption) and strongyloidiasis (threadworm infection).
Although not considered a primary agent, thiabendazole is also indicated for treating other infections, such as enterobiasis (pinworm), toxocariasis (visceral larva migrans), uncinariasis (hookworm: Ancylostoma duodenale or Necator americanus), trichuriasis (whipworm), and ascariasis (roundworm), and for managing symptoms of invasive-stage trichinosis infection.
Thiabendazole should not be used to treat mixed infections with ascaris because it can cause the worms to migrate.
Because of the toxicity that may be associated with oral administration, topical application is currently the formulation of choice for the treatment of localized cutaneous larva migrans. Thiabendazole was approved by the FDA in 1967.
Brand Name
Mintezol
Indications
- Ancylostoma braziliense
- Ancylostoma caninum
- Ancylostoma duodenale
- Angiostrongylus cantonensis
- Angiostrongylus costaricensis
- anisakiasis
- ascariasis
- Ascaris lumbricoides
- Capillaria philippinensis
- capillariasis
- cutaneous larva migrans
- dracunculiasis
- Dracunculus medinensis
- enterobiasis (pinworm infection)
- Enterobius vermicularis
- Microsporum sp.
- Necator americanus
- Strongyloides stercoralis
- strongyloidiasis
- toxocariasis
- Trichinella spiralis
- trichinosis
- Trichophyton sp.
- trichostrongyliasis
- Trichostrongylus sp.
- trichuriasis
- Trichuris trichiura
- uncinariasis
Side Effects
- abdominal pain
- anaphylactoid reactions
- angioedema
- anorexia
- azotemia
- blurred vision
- cholestasis
- confusion
- crystalluria
- diarrhea
- dizziness
- drowsiness
- elevated hepatic enzymes
- hallucinations
- headache
- hepatic failure
- hypotension
- irritability
- jaundice
- nausea
- ocular irritation
- pruritus
- seizures
- Stevens-Johnson syndrome
- tinnitus
- urticaria
- vomiting
- weakness
- xanthopsia
- xerophthalmia
- xerostomia
Monitoring Parameters
- LFTs
- pregnancy testing
- serum creatinine/BUN
- stool exam
Contraindications
- anemia
- breast-feeding
- dehydration
- driving or operating machinery
- hepatic disease
- pregnancy
- renal impairment
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Alosetron
- Anagrelide
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Bendamustine
- Bupivacaine; Lidocaine
- Caffeine
- Caffeine; Ergotamine
- Ciprofloxacin
- Clozapine
- Dyphylline
- Dyphylline; Guaifenesin
- Eltrombopag
- Fluoxetine; Olanzapine
- Frovatriptan
- Green Tea
- Lidocaine
- Lidocaine; Prilocaine
- Melatonin
- Mexiletine
- Obeticholic Acid
- Olanzapine
- Pimozide
- Pirfenidone
- Pomalidomide
- Ramelteon
- Rasagiline
- Riluzole
- Ropinirole
- Ropivacaine
- Simeprevir
- Tacrine
- Tasimelteon
- Terbinafine
- Theophylline, Aminophylline
- Tizanidine
- Vemurafenib
- Zileuton
