What is Sulfisoxazole
Sulfisoxazole is a sulfonamide antibiotic, similar to sulfamethoxazole, but with notable differences.
Sulfisoxazole is short-acting and must be dosed four times per day.
Sulfisoxazole exhibits a higher degree of protein binding than sulfamethoxazole, which may increase the likelihood for interactions with other highly bound drugs.
Finally, sulfisoxazole is extensively eliminated unchanged in the urine and is less desirable for use in patients with compromised renal function.
Sulfisoxazole was approved by the FDA in 1948.
Brand Name
Gantrisin
Indications
- Actinomyces sp.
- cervicitis
- chancroid
- chlamydia infection
- Chlamydia trachomatis
- chlamydial conjunctivitis
- Clostridium perfringens
- Clostridium tetani
- cystitis
- Enterobacter sp.
- Escherichia coli
- Haemophilus ducreyi
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella sp.
- lymphogranuloma venereum
- malaria
- meningitis
- Neisseria meningitidis
- Nocardia asteroides
- Nocardia brasiliensis
- nocardiosis
- otitis media
- Plasmodium falciparum
- proctitis
- Proteus mirabilis
- Proteus vulgaris
- pyelonephritis
- Salmonella sp.
- Shigella sp.
- Staphylococcus sp.
- Streptococcus pneumoniae
- Streptococcus sp.
- Toxoplasma gondii
- urethritis
- urinary tract infection (UTI)
- Yersinia pestis
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactoid reactions
- angioedema
- anorexia
- anuria
- anxiety
- aplastic anemia
- arthralgia
- ataxia
- bullous rash
- chills
- cough
- crystalluria
- cyanosis
- depression
- diarrhea
- diuresis
- dizziness
- drowsiness
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- erythema nodosum
- exfoliative dermatitis
- fatigue
- flatulence
- flushing
- GI bleeding
- glossitis
- goiter
- hallucinations
- headache
- hearing loss
- hematuria
- hemolytic anemia
- hepatic necrosis
- hepatitis
- hypoglycemia
- hypoprothrombinemia
- increased intracranial pressure
- insomnia
- interstitial nephritis
- jaundice
- lethargy
- leukopenia
- lupus-like symptoms
- maculopapular rash
- melena
- methemoglobinemia
- myalgia
- myocarditis
- nausea
- oliguria
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- periarteritis
- peripheral neuropathy
- photosensitivity
- pneumonitis
- pruritus
- pseudomembranous colitis
- psychosis
- purpura
- renal failure (unspecified)
- seizures
- serum sickness
- sialadenitis
- sinus tachycardia
- Stevens-Johnson syndrome
- stomatitis
- syncope
- thrombocytopenia
- tinnitus
- toxic epidermal necrolysis
- urinary retention
- urticaria
- vasculitis
- vertigo
- vomiting
- weakness
Monitoring Parameters
- CBC
- serum creatinine/BUN
Contraindications
- bone marrow suppression
- breast-feeding
- carbonic anhydrase inhibitor hypersensitivity
- colitis
- dental disease
- diarrhea
- folate deficiency megaloblastic anemia
- G6PD deficiency
- geriatric
- GI disease
- hepatic disease
- infants
- inflammatory bowel disease
- neonates
- porphyria
- pregnancy
- pseudomembranous colitis
- renal disease
- renal impairment
- sulfonamide hypersensitivity
- sulfonylurea hypersensitivity
- sunlight (UV) exposure
- thiazide diuretic hypersensitivity
- ulcerative colitis
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acarbose
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetohexamide
- Albiglutide
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Aminosalicylate sodium, Aminosalicylic acid
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Ampicillin
- Ampicillin; Sulbactam
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzocaine
- Benzocaine; Butamben; Tetracaine
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bosentan
- Bromocriptine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Canagliflozin
- Canagliflozin; Metformin
- Chloroprocaine
- Chlorpropamide
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Dicloxacillin
- Dienogest; Estradiol valerate
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Naproxen
- Dulaglutide
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Exenatide
- Fenoprofen
- Fluvastatin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Hydrochlorothiazide, HCTZ; Losartan
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Incretin Mimetics
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Lamivudine, 3TC; Zidovudine, ZDV
- Lansoprazole; Naproxen
- Lidocaine
- Linagliptin; Metformin
- Liraglutide
- Lixisenatide
- Losartan
- Magnesium Salicylate
- Meglitinides
- Mepivacaine
- Mepivacaine; Levonordefrin
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methenamine
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methotrexate
- Methoxsalen
- Miglitol
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Omeprazole; Amoxicillin; Rifabutin
- Oral Contraceptives
- Oxacillin
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Photosensitizing agents (topical)
- Piperacillin
- Piperacillin; Tazobactam
- Porfimer
- Pramlintide
- Prilocaine
- Prilocaine; Epinephrine
- Probenecid
- Pyrimethamine
- Pyrimethamine; Sulfadoxine
- Ropivacaine
- Salicylates
- Salsalate
- Semaglutide
- SGLT2 Inhibitors
- Sodium Iodide
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfinpyrazone
- Sulfonylureas
- Tetracaine
- Thiazolidinediones
- Tolazamide
- Tolbutamide
- Typhoid Vaccine
- Verteporfin
- Voriconazole
- Warfarin
- Zidovudine, ZDV
