Sulfisoxazole

What is Sulfisoxazole

Sulfisoxazole is a sulfonamide antibiotic, similar to sulfamethoxazole, but with notable differences.

Sulfisoxazole is short-acting and must be dosed four times per day.

Sulfisoxazole exhibits a higher degree of protein binding than sulfamethoxazole, which may increase the likelihood for interactions with other highly bound drugs.

Finally, sulfisoxazole is extensively eliminated unchanged in the urine and is less desirable for use in patients with compromised renal function.

Sulfisoxazole was approved by the FDA in 1948.

Brand Name

Gantrisin

Indications

  1. Actinomyces sp.
  2. cervicitis
  3. chancroid
  4. chlamydia infection
  5. Chlamydia trachomatis
  6. chlamydial conjunctivitis
  7. Clostridium perfringens
  8. Clostridium tetani
  9. cystitis
  10. Enterobacter sp.
  11. Escherichia coli
  12. Haemophilus ducreyi
  13. Haemophilus influenzae (beta-lactamase negative)
  14. Haemophilus influenzae (beta-lactamase positive)
  15. Klebsiella sp.
  16. lymphogranuloma venereum
  17. malaria
  18. meningitis
  19. Neisseria meningitidis
  20. Nocardia asteroides
  21. Nocardia brasiliensis
  22. nocardiosis
  23. otitis media
  24. Plasmodium falciparum
  25. proctitis
  26. Proteus mirabilis
  27. Proteus vulgaris
  28. pyelonephritis
  29. Salmonella sp.
  30. Shigella sp.
  31. Staphylococcus sp.
  32. Streptococcus pneumoniae
  33. Streptococcus sp.
  34. Toxoplasma gondii
  35. urethritis
  36. urinary tract infection (UTI)
  37. Yersinia pestis

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactoid reactions
  4. angioedema
  5. anorexia
  6. anuria
  7. anxiety
  8. aplastic anemia
  9. arthralgia
  10. ataxia
  11. bullous rash
  12. chills
  13. cough
  14. crystalluria
  15. cyanosis
  16. depression
  17. diarrhea
  18. diuresis
  19. dizziness
  20. drowsiness
  21. dyspnea
  22. elevated hepatic enzymes
  23. eosinophilia
  24. erythema multiforme
  25. erythema nodosum
  26. exfoliative dermatitis
  27. fatigue
  28. flatulence
  29. flushing
  30. GI bleeding
  31. glossitis
  32. goiter
  33. hallucinations
  34. headache
  35. hearing loss
  36. hematuria
  37. hemolytic anemia
  38. hepatic necrosis
  39. hepatitis
  40. hypoglycemia
  41. hypoprothrombinemia
  42. increased intracranial pressure
  43. insomnia
  44. interstitial nephritis
  45. jaundice
  46. lethargy
  47. leukopenia
  48. lupus-like symptoms
  49. maculopapular rash
  50. melena
  51. methemoglobinemia
  52. myalgia
  53. myocarditis
  54. nausea
  55. oliguria
  56. palpitations
  57. pancreatitis
  58. pancytopenia
  59. paresthesias
  60. periarteritis
  61. peripheral neuropathy
  62. photosensitivity
  63. pneumonitis
  64. pruritus
  65. pseudomembranous colitis
  66. psychosis
  67. purpura
  68. renal failure (unspecified)
  69. seizures
  70. serum sickness
  71. sialadenitis
  72. sinus tachycardia
  73. Stevens-Johnson syndrome
  74. stomatitis
  75. syncope
  76. thrombocytopenia
  77. tinnitus
  78. toxic epidermal necrolysis
  79. urinary retention
  80. urticaria
  81. vasculitis
  82. vertigo
  83. vomiting
  84. weakness

Monitoring Parameters

  • CBC
  • serum creatinine/BUN

Contraindications

  • bone marrow suppression
  • breast-feeding
  • carbonic anhydrase inhibitor hypersensitivity
  • colitis
  • dental disease
  • diarrhea
  • folate deficiency megaloblastic anemia
  • G6PD deficiency
  • geriatric
  • GI disease
  • hepatic disease
  • infants
  • inflammatory bowel disease
  • neonates
  • porphyria
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal impairment
  • sulfonamide hypersensitivity
  • sulfonylurea hypersensitivity
  • sunlight (UV) exposure
  • thiazide diuretic hypersensitivity
  • ulcerative colitis

Interactions

  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Acarbose
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetohexamide
  • Albiglutide
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amoxicillin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amoxicillin; Clavulanic Acid
  • Ampicillin
  • Ampicillin; Sulbactam
  • Articaine; Epinephrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzocaine
  • Benzocaine; Butamben; Tetracaine
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bosentan
  • Bromocriptine
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Canagliflozin
  • Canagliflozin; Metformin
  • Chloroprocaine
  • Chlorpropamide
  • Choline Salicylate; Magnesium Salicylate
  • Colchicine; Probenecid
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Dapsone
  • Dicloxacillin
  • Dienogest; Estradiol valerate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Naproxen
  • Dulaglutide
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esomeprazole; Naproxen
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Exenatide
  • Fenoprofen
  • Fluvastatin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Incretin Mimetics
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lansoprazole; Naproxen
  • Lidocaine
  • Linagliptin; Metformin
  • Liraglutide
  • Lixisenatide
  • Losartan
  • Magnesium Salicylate
  • Meglitinides
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methotrexate
  • Methoxsalen
  • Miglitol
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Omeprazole; Amoxicillin; Rifabutin
  • Oral Contraceptives
  • Oxacillin
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Penicillin V
  • Photosensitizing agents (topical)
  • Piperacillin
  • Piperacillin; Tazobactam
  • Porfimer
  • Pramlintide
  • Prilocaine
  • Prilocaine; Epinephrine
  • Probenecid
  • Pyrimethamine
  • Pyrimethamine; Sulfadoxine
  • Ropivacaine
  • Salicylates
  • Salsalate
  • Semaglutide
  • SGLT2 Inhibitors
  • Sodium Iodide
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfinpyrazone
  • Sulfonylureas
  • Tetracaine
  • Thiazolidinediones
  • Tolazamide
  • Tolbutamide
  • Typhoid Vaccine
  • Verteporfin
  • Voriconazole
  • Warfarin
  • Zidovudine, ZDV
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