Sugammadex

What is Sugammadex

Sugammadex is a modified gamma cyclodextrin for the reversal of neuromuscular blockade effects of rocuronium and vecuronium in adults undergoing surgery.

Sugammadex use for reversal of neuromuscular blockade in the intensive care unit or for reversal of nonsteroidal neuromuscular blocking agents or steroidal neuromuscular blocking agents other than rocuronium and vecuronium has not been studied.

Cases of marked bradycardia, some resulting in cardiac arrest, have been observed within minutes of sugammadex administration; hemodynamic parameters should be monitored for changes during and after sugammadex receipt. Sugammadex was FDA-approved in December 2015.

Brand Name

Bridion

Indications

  • neuromuscular blockade reversal

The use of sugammadex for neuromuscular blockade reversal following rocuronium or vecuronium administration in the intensive care unit has not been studied.

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. anemia
  4. angioedema
  5. anxiety
  6. atrial fibrillation
  7. AV block
  8. bleeding
  9. bradycardia
  10. bronchospasm
  11. cardiac arrest
  12. chills
  13. cough
  14. depression
  15. dizziness
  16. dyspnea
  17. edema
  18. erythema
  19. fever
  20. flatulence
  21. flushing
  22. headache
  23. hypertension
  24. hypocalcemia
  25. hypoesthesia
  26. hypotension
  27. insomnia
  28. laryngospasm
  29. musculoskeletal pain
  30. myalgia
  31. nausea
  32. pruritus
  33. pulmonary edema
  34. QT prolongation
  35. respiratory arrest
  36. restlessness
  37. supraventricular tachycardia (SVT)
  38. throat irritation
  39. urticaria
  40. ventricular fibrillation
  41. ventricular tachycardia
  42. vomiting
  43. wheezing
  44. xerostomia

Monitoring Parameters

  • arterial blood gases (ABGs)
  • peripheral nerve stimulation

Contraindications

  • bleeding
  • bradycardia
  • breast-feeding
  • coagulopathy
  • dialysis
  • geriatric
  • neuromuscular blockade recurrence
  • pregnancy
  • renal impairment
  • respiratory depression

Interactions

  • Conjugated Estrogens; Medroxyprogesterone
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etonogestrel
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Medroxyprogesterone
  • Mestranol; Norethindrone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Segesterone Acetate; Ethinyl Estradiol
  • Toremifene
You cannot copy content of this page