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What is Ranolazine
Ranolazine is a piperazine derivative and is the first novel drug approved for the treatment of chronic angina in over 20 years.
Ranolazine is unrelated to other available antianginal agents.
Ranolazine does not possess negative chronotropic or inotropic effects, and minimal effects on heart rate and blood pressure have been noted during clinical trials.
Brand Name
Ranexa
Indications
- acute myocardial infarction, NSTEMI
- angina
- unstable angina
For the treatment of chronic angina
NOTE: The concomitant use of ranolazine and CYP3A inducers or strong CYP3A inhibitors is contraindicated.
NOTE: The effects of ranolazine on angina frequency and exercise tolerance are considerably smaller in women than in men.
Side Effects
- abdominal pain
- angioedema
- anorexia
- asthenia
- azotemia
- blurred vision
- bradycardia
- confusion
- constipation
- dizziness
- dyspepsia
- dyspnea
- dysuria
- eosinophilia
- hallucinations
- headache
- hematuria
- hyperhidrosis
- hypoesthesia
- hypoglycemia
- hypotension
- leukopenia
- myoclonia
- nausea
- orthostatic hypotension
- palpitations
- pancytopenia
- paresthesias
- peripheral edema
- pruritus
- pulmonary fibrosis
- QT prolongation
- rash
- renal failure (unspecified)
- syncope
- thrombocytopenia
- tinnitus
- tremor
- urinary retention
- vertigo
- vomiting
- xerostomia
Monitoring Parameters
- ECG
- LFTs
- serum creatinine/BUN
- serum magnesium
- serum potassium
Contraindications
- alcoholism
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- long QT syndrome
- malnutrition
- myocardial infarction
- pregnancy
- QT prolongation
- renal failure
- renal impairment
- syncope
- thyroid disease
Interactions
- Abarelix
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Afatinib
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Alogliptin; Metformin
- Alprazolam
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Atorvastatin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Azithromycin
- Barbiturates
- Bedaquiline
- Benzhydrocodone; Acetaminophen
- Betrixaban
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bosentan
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Brimonidine; Timolol
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
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- Cabozantinib
- Canagliflozin; Metformin
- Capmatinib
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- Carvedilol
- Cenobamate
- Ceritinib
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Cilostazol
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- Cinacalcet
- Ciprofloxacin
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