What is Rifamycin

Rifamycin is an oral ansamycin class antibacterial drug indicated for treatment of traveler’s diarrhea caused by noninvasive strains of Escherichia coli (E. coli), not complicated by fever or blood in the stool.

Rifamycin is minimally absorbed; therefore, systemic concentrations are generally below the level of detection.

Clinically relevant drug interactions are not expected.

The multi-matrix structure (MMX) technology creates a modified-release formulation that allows rifamycin to be delivered to the distal small bowel and colon without interfering with the normal flora in the upper GI tract.

Brand Name



  • Escherichia coli
  • traveler’s diarrhea

Side Effects

  1. abdominal pain
  2. constipation
  3. dyspepsia
  4. fever
  5. headache
  6. pseudomembranous colitis

Monitoring Parameters

  • laboratory monitoring not necessary


  • breast-feeding
  • colitis
  • diarrhea
  • fever
  • geriatric
  • GI bleeding
  • GI disease
  • inflammatory bowel disease
  • pregnancy
  • pseudomembranous colitis
  • rifamycin hypersensitivity
  • ulcerative colitis


There are no drug interactions associated with Rifamycin products.


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