Sulfacetamide and Sulfur

What is Sulfacetamide and Sulfur combination medicine

Sulfacetamide and sulfur are used together in a topical preparation to treat acne rosacea, acne vulgaris, and seborrheic dermatitis. Sulfacetamide is a sulfonamide antibiotic.

Sulfur is a topical antimicrobial and keratolytic agent that causes a peeling and drying action.

Sulfacetamide and sulfur has been historically used in dermatology for many decades, and was initially marketed for use before 1962, which is when Congress passed the amended Federal Food, Drug, and Cosmetic Act requiring that the FDA establish both safety and efficacy for all subsequently approved drugs. Sulfacetamide; sulfur is an unapproved marketed drug that has not been formally evaluated by the FDA.

Indications & Dosage

  • acne rosacea
  • acne vulgaris
  • seborrheic dermatitis

Side Effects

  1. agranulocytosis
  2. contact dermatitis
  3. edema
  4. erythema
  5. exfoliative dermatitis
  6. fever
  7. hemolytic anemia
  8. jaundice
  9. photosensitivity
  10. pruritus
  11. purpura
  12. skin irritation
  13. Stevens-Johnson syndrome

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • asthma
  • breast-feeding
  • carbonic anhydrase inhibitor hypersensitivity
  • children
  • infants
  • neonates
  • ocular exposure
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • skin abrasion
  • skin photosensitivity disorder
  • sulfite hypersensitivity
  • sulfonamide hypersensitivity
  • sulfonylurea hypersensitivity
  • sunlight (UV) exposure
  • thiazide diuretic hypersensitivity

Interactions

  • Acetohexamide
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Atenolol; Chlorthalidone
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gentamicin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Methoxsalen
  • Methyclothiazide
  • Metolazone
  • Photosensitizing agents (topical)
  • Silver Nitrate
  • Silver Sulfadiazine
  • Sulfonylureas
  • Thiazide diuretics
  • Tolazamide
  • Tolbutamide
  • Voriconazole