Tamsulosin

What is Tamsulosin

Tamsulosin is an oral alpha-blocker that can be administered once-daily for the treatment of benign prostatic hyperplasia (BPH).

Tamsulosin appears to cause less hypotension than other alpha-blockers due to enhanced specificity for the alpha-receptors on the prostate.

As a result, tamsulosin therapy can be initiated at the optimum dose whereas other alpha-blockers require gradual upward titration to reduce the risk of an exaggerated response to the ‘first-dose’ effects. 

Brand Name

Flomax

Indications

  • benign prostatic hyperplasia (BPH)
  • nephrolithiasis

For the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)

Side Effects

  1. angioedema
  2. arrhythmia exacerbation
  3. asthenia
  4. atrial fibrillation
  5. back pain
  6. blurred vision
  7. chest pain (unspecified)
  8. constipation
  9. cough
  10. diarrhea
  11. dizziness
  12. drowsiness
  13. dyspnea
  14. ejaculation dysfunction
  15. epistaxis
  16. erythema multiforme
  17. exfoliative dermatitis
  18. floppy iris syndrome
  19. headache
  20. hypotension
  21. infection
  22. insomnia
  23. libido decrease
  24. nausea
  25. orthostatic hypotension
  26. palpitations
  27. pharyngitis
  28. priapism
  29. pruritus
  30. rash
  31. rhinitis
  32. sinus tachycardia
  33. sinusitis
  34. Stevens-Johnson syndrome
  35. syncope
  36. urticaria
  37. vertigo
  38. visual impairment
  39. vomiting
  40. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • geriatric
  • hepatic disease
  • infants
  • ocular surgery
  • orthostatic hypotension
  • pregnancy
  • priapism
  • prostate cancer
  • renal failure
  • renal impairment
  • sulfonamide hypersensitivity
  • syncope

Interactions

  • Abiraterone
  • Acebutolol
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Propoxyphene
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alpha-blockers
  • Ambrisentan
  • Amiodarone
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Aprepitant, Fosaprepitant
  • Artemether; Lumefantrine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Avanafil
  • Bendroflumethiazide; Nadolol
  • Beta-blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Brimonidine; Timolol
  • Bupropion
  • Bupropion; Naltrexone
  • Calcium-channel blockers
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carteolol
  • Carvedilol
  • Ceritinib
  • Chloramphenicol
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Cimetidine
  • Cinacalcet
  • Citalopram
  • Clarithromycin
  • Clevidipine
  • Cobicistat
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Dacomitinib
  • Danazol
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diltiazem
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dorzolamide; Timolol
  • Doxazosin
  • Dronedarone
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enalapril; Felodipine
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esmolol
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Everolimus
  • Fedratinib
  • Felodipine
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • Fosamprenavir
  • grapefruit juice
  • Halofantrine
  • Haloperidol
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Idelalisib
  • Iloprost
  • Imatinib
  • Indinavir
  • Isavuconazonium
  • Isradipine
  • Itraconazole
  • Ketoconazole
  • Labetalol
  • Lefamulin
  • Letermovir
  • Levobetaxolol
  • Levobunolol
  • Lopinavir; Ritonavir
  • Meperidine; Promethazine
  • Metoprolol
  • Mifepristone
  • Mirabegron
  • Mitotane
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nelfinavir
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Paroxetine
  • Pazopanib
  • Peginterferon Alfa-2b
  • Penbutolol
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenoxybenzamine
  • Phentolamine
  • Phenylephrine; Promethazine
  • Pindolol
  • Posaconazole
  • Prazosin
  • Promethazine
  • Propafenone
  • Propoxyphene
  • Propranolol
  • Protease inhibitors
  • Quinidine
  • Quinine
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Ritonavir
  • Rolapitant
  • Saquinavir
  • Segesterone Acetate; Ethinyl Estradiol
  • Sertraline
  • Sildenafil
  • Silodosin
  • Simeprevir
  • Sotalol
  • Tadalafil
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Terazosin
  • Terbinafine
  • Thioridazine
  • Timolol
  • Tipranavir
  • Trandolapril; Verapamil
  • Tucatinib
  • Vardenafil
  • Vemurafenib
  • Verapamil
  • Voriconazole
  • Warfarin
  • Zafirlukast
  • Zileuton
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