What is Tamoxifen
Tamoxifen is an oral selective estrogen receptor modulator (SERM), which has both estrogenic and antiestrogenic effects on various tissues.
It competes with estrogen for binding to the estrogen receptor, which can decrease estrogen receptor signaling-dependent growth in breast tissue.
It is approved for the adjuvant treatment of breast cancer and for the treatment of metastatic breast cancer.
It is also used to reduce the risk of invasive breast cancer in women with ductal carcinoma in situ (DCIS) after surgery and radiation, and to reduce the risk of breast cancer in women at high risk for breast cancer.
Brand Names
Nolvadex | Soltamox
Indications
- bipolar disorder
- breast cancer
- breast cancer prophylaxis
- desmoid tumor
- infertility
- malignant glioma
- malignant melanoma
- mastalgia
- osteoporosis
- ovarian cancer
- precocious puberty
Side Effects
- abdominal pain
- alopecia
- amenorrhea
- anemia
- angioedema
- anorexia
- anxiety
- arthralgia
- asthenia
- back pain
- bleeding
- bone pain
- bullous rash
- cataracts
- chest pain (unspecified)
- cholestasis
- constipation
- cough
- depression
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- endometrial cancer
- endometrial hyperplasia
- erythema
- erythema multiforme
- fatigue
- fetal death
- fluid retention
- flushing
- headache
- hepatic necrosis
- hepatitis
- hot flashes
- hot flashes
- hyperbilirubinemia
- hypercalcemia
- hypercholesterolemia
- hyperhidrosis
- hypertension
- hypertriglyceridemia
- impotence (erectile dysfunction)
- infection
- influenza
- insomnia
- leukopenia
- leukorrhea
- libido decrease
- mastalgia
- menstrual irregularity
- musculoskeletal pain
- myalgia
- nausea
- neutropenia
- new primary malignancy
- oligomenorrhea
- pancreatitis
- pancytopenia
- paresthesias
- peripheral edema
- peripheral vasodilation
- pharyngitis
- phlebitis
- pneumonitis
- pruritus
- pulmonary embolism
- rash
- retinal thrombosis
- retinopathy
- sinusitis
- spontaneous fetal abortion
- steatosis
- Stevens-Johnson syndrome
- stroke
- teratogenesis
- throat irritation
- thrombocytopenia
- thrombocytopenia
- thromboembolism
- thrombosis
- tumor flare
- vaginal bleeding
- vaginal discharge
- vaginal discharge
- vaginitis
- visual impairment
- vomiting
- weight gain
- weight loss
Monitoring Parameters
- CBC
- LFTs
- pregnancy testing
- serum calcium
- serum lipid profile
- serum triglycerides
Contraindications
- anemia
- anticoagulant therapy
- bone marrow suppression
- breast-feeding
- cataracts
- chemotherapy
- children
- contraception requirements
- endometrial cancer
- endometrial hyperplasia
- hepatic disease
- hypercalcemia
- hypercholesterolemia
- hyperlipidemia
- hypertriglyceridemia
- infertility
- leukopenia
- menstrual irregularity
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- reproductive risk
- stroke
- thrombocytopenia
- thromboembolism
- uterine cancer
- visual disturbance
- visual impairment
- ed Estrogens; Medroxyprogesterone
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