What is Sulindac
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the indole and indene acetic acid chemical class.
Sulindac possesses analgesic and antipyretic properties. Because the sulfone metabolite is inactive and is largly renally excreted, nephrotoxicity relative to other NSAIDs is hypothesized to be less. However, recent data do not support this hypothesis. More data are needed.
Sulindac and celecoxib are the only NSAIDs that appear to be effective for the regression of colorectal polyps in patients with familial adenomatous polyposis (FAP).
According to guidelines from The American Society of Colon and Rectal Surgeons, sulindac should not be used for the prevention or primary treatment of FAP with the exception of patients with pouch polyposis or selected patients with rectal polyposis after ileorectal anastomosis in whom surgery is undesirable.
Brand Name
Clinoril
Indications
- ankylosing spondylitis
- arthralgia
- bone pain
- bursitis
- desmoid tumor
- familial adenomatous polyposis
- gouty arthritis
- headache
- juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
- migraine
- moderate pain
- myalgia
- osteoarthritis
- rheumatoid arthritis
- tendinitis
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- anxiety
- aplastic anemia
- aseptic meningitis
- blurred vision
- bronchospasm
- cholestasis
- colitis
- confusion
- constipation
- crystalluria
- depression
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- fever
- flatulence
- gastritis
- GI bleeding
- GI perforation
- glossitis
- gynecomastia
- headache
- hearing loss
- heart failure
- hematuria
- hemolytic anemia
- hepatic failure
- hepatitis
- hyperglycemia
- hyperkalemia
- hypertension
- hyponatremia
- insomnia
- interstitial nephritis
- jaundice
- leukopenia
- malaise
- metallic taste
- myasthenia
- myocardial infarction
- nausea
- necrotizing fasciitis
- nephrolithiasis
- nephrotic syndrome
- neuritis
- neutropenia
- odynophagia
- palpitations
- pancreatitis
- paresthesias
- peptic ulcer
- peripheral edema
- photophobia
- photosensitivity
- platelet dysfunction
- proteinuria
- pruritus
- psychosis
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- seizures
- Stevens-Johnson syndrome
- stomatitis
- stroke
- syncope
- thrombocytopenia
- thromboembolism
- tinnitus
- toxic epidermal necrolysis
- urine discoloration
- urticaria
- vaginal bleeding
- vasculitis
- vertigo
- visual impairment
- vomiting
- weight gain
- xerostomia
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
- stool guaiac
Contraindications
- acute bronchospasm
- acute myocardial infarction
- alcoholism
- anemia
- angina
- anticoagulant therapy
- asthma
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cerebrovascular disease
- chemotherapy
- children
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dehydration
- dental disease
- dental work
- diabetes mellitus
- dysphagia
- edema
- esophageal stricture
- esophagitis
- geriatric
- GI bleeding
- GI disease
- GI perforation
- heart failure
- hematological disease
- hemophilia
- hepatic disease
- hypertension
- hypovolemia
- immunosuppression
- intramuscular injections
- jaundice
- labor
- myocardial infarction
- nasal polyps
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- rheumatoid arthritis
- salicylate hypersensitivity
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- tachycardia
- thrombocytopenia
- thromboembolism
- tobacco smoking
- ulcerative colitis
- urticaria
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetohexamide
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- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
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- Aspirin, ASA; Carisoprodol; Codeine
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- food
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- Hydrochlorothiazide, HCTZ; Propranolol
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- Hydrochlorothiazide, HCTZ; Triamterene
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- Hydrocodone; Ibuprofen
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- Hydroxyurea
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