Sumatriptan

What is Sumatriptan

Sumatriptan is a serotonin-receptor 1B and 1D agonist (triptan) indicated for the acute treatment of migraine with or without aura. Some formulations of subcutaneous sumatriptan are also indicated for the treatment of cluster headaches.

Sumatriptan is not indicated for long-term migraine prophylaxis or for the management of hemiplegic or basilar migraine.

Serious cardiac adverse effects may occur during sumatriptan administration and are more likely to occur in patients with risk factors for coronary artery disease, although some events have occurred in patients without known cardiac risk factors.

Indications

  • cluster headache
  • migraine

For the acute treatment of migraine attacks with or without aura

Side Effects

  1. abdominal pain
  2. agitation
  3. anaphylactoid reactions
  4. anemia
  5. angina
  6. angioedema
  7. anxiety
  8. arthralgia
  9. atopic dermatitis
  10. atrial fibrillation
  11. AV block
  12. back pain
  13. bleeding
  14. blurred vision
  15. bowel ischemia
  16. bradycardia
  17. breast discharge
  18. bronchospasm
  19. cardiac arrest
  20. cardiomyopathy
  21. chest pain (unspecified)
  22. chest pressure syndrome
  23. chills
  24. colitis
  25. confusion
  26. conjunctivitis
  27. constipation
  28. contact dermatitis
  29. coronary vasospasm
  30. cough
  31. cyanosis
  32. cystitis
  33. dehydration
  34. dental pain
  35. depression
  36. diarrhea
  37. dizziness
  38. drowsiness
  39. dysarthria
  40. dysesthesia
  41. dysgeusia
  42. dysmenorrhea
  43. dysphagia
  44. dyspnea
  45. dystonic reaction
  46. dysuria
  47. edema
  48. elevated hepatic enzymes
  49. endometrial hyperplasia
  50. epistaxis
  51. eructation
  52. erythema
  53. euphoria
  54. fatigue
  55. fever
  56. flatulence
  57. fluid retention
  58. flushing
  59. galactorrhea
  60. gastritis
  61. gastroesophageal reflux
  62. GI bleeding
  63. GI obstruction
  64. hallucinations
  65. headache
  66. hearing loss
  67. hematemesis
  68. hematuria
  69. hemolytic anemia
  70. hiccups
  71. hyperacusis
  72. hyperesthesia
  73. hyperglycemia
  74. hyperhidrosis
  75. hypersalivation
  76. hypertension
  77. hypertensive crisis
  78. hyperthermia
  79. hypoglycemia
  80. hypotension
  81. hypothyroidism
  82. increased urinary frequency
  83. infection
  84. influenza
  85. injection site reaction
  86. intracranial bleeding
  87. keratitis
  88. lacrimation
  89. lymphadenopathy
  90. malaise
  91. melena
  92. memory impairment
  93. menstrual irregularity
  94. muscle cramps
  95. myalgia
  96. myasthenia
  97. mydriasis
  98. myocardial infarction
  99. myoclonia
  100. nausea
  101. nephrolithiasis
  102. ocular hemorrhage
  103. ocular irritation
  104. ocular pain
  105. ocular pruritus
  106. otalgia
  107. pallor
  108. palpitations
  109. pancreatitis
  110. pancytopenia
  111. paresthesias
  112. parosmia
  113. peptic ulcer
  114. peripheral vasoconstriction
  115. peripheral vasodilation
  116. phlebitis
  117. phobia
  118. photophobia
  119. photosensitivity
  120. polydipsia
  121. premature atrial contractions (PACs)
  122. premature ventricular contractions (PVCs)
  123. pruritus
  124. pulmonary embolism
  125. QT prolongation
  126. rash
  127. renal failure (unspecified)
  128. retinal thrombosis
  129. rhinalgia
  130. rhinitis
  131. rhinorrhea
  132. seborrhea
  133. seizures
  134. serotonin syndrome
  135. shivering
  136. sinus tachycardia
  137. sinusitis
  138. skin irritation
  139. spontaneous fetal abortion
  140. ST-T wave changes
  141. stroke
  142. suicidal ideation
  143. syncope
  144. tetany
  145. thrombocytopenia
  146. thrombosis
  147. tinnitus
  148. tremor
  149. urticaria
  150. vasculitis
  151. ventricular fibrillation
  152. ventricular tachycardia
  153. vertigo
  154. visual impairment
  155. vomiting
  156. weight gain
  157. weight loss
  158. withdrawal
  159. xerosis
  160. xerostomia
  161. yawning

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • angina
  • arteriosclerosis
  • basilar/hemiplegic migraine
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cerebrovascular disease
  • children
  • colitis
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • geriatric
  • hepatic disease
  • hypercholesterolemia
  • hypertension
  • intracranial bleeding
  • intravenous administration
  • latex hypersensitivity
  • magnetic resonance imaging (MRI)
  • MAOI therapy
  • obesity
  • peripheral vascular disease
  • pregnancy
  • Raynaud’s phenomenon
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • stroke
  • sumatriptan hypersensitivity
  • tobacco smoking
  • vasospastic angina
  • visual disturbance
  • Wolff-Parkinson-White syndrome

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Alfentanil
  • Almotriptan
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Bromocriptine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Citalopram
  • Clomipramine
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Desipramine
  • Desvenlafaxine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextroamphetamine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Doxepin
  • Droxidopa
  • Duloxetine
  • Eletriptan
  • Ergot alkaloids
  • Escitalopram
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • Frovatriptan
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Imipramine
  • Isocarboxazid
  • Lasmiditan
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lorcaserin
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methylene Blue
  • Milnacipran
  • Mirtazapine
  • Morphine
  • Morphine; Naltrexone
  • Nalbuphine
  • Naratriptan
  • Nefazodone
  • Nortriptyline
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paroxetine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Protriptyline
  • Rasagiline
  • Remifentanil
  • Rizatriptan
  • Selective serotonin reuptake inhibitors
  • Selegiline
  • Sertraline
  • Sibutramine
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Tapentadol
  • Tedizolid
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Tricyclic antidepressants
  • Trimipramine
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Zolmitriptan
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