What is Sumatriptan
Sumatriptan is a serotonin-receptor 1B and 1D agonist (triptan) indicated for the acute treatment of migraine with or without aura. Some formulations of subcutaneous sumatriptan are also indicated for the treatment of cluster headaches.
Sumatriptan is not indicated for long-term migraine prophylaxis or for the management of hemiplegic or basilar migraine.
Serious cardiac adverse effects may occur during sumatriptan administration and are more likely to occur in patients with risk factors for coronary artery disease, although some events have occurred in patients without known cardiac risk factors.
Indications
- cluster headache
- migraine
For the acute treatment of migraine attacks with or without aura
Side Effects
- abdominal pain
- agitation
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anxiety
- arthralgia
- atopic dermatitis
- atrial fibrillation
- AV block
- back pain
- bleeding
- blurred vision
- bowel ischemia
- bradycardia
- breast discharge
- bronchospasm
- cardiac arrest
- cardiomyopathy
- chest pain (unspecified)
- chest pressure syndrome
- chills
- colitis
- confusion
- conjunctivitis
- constipation
- contact dermatitis
- coronary vasospasm
- cough
- cyanosis
- cystitis
- dehydration
- dental pain
- depression
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dysesthesia
- dysgeusia
- dysmenorrhea
- dysphagia
- dyspnea
- dystonic reaction
- dysuria
- edema
- elevated hepatic enzymes
- endometrial hyperplasia
- epistaxis
- eructation
- erythema
- euphoria
- fatigue
- fever
- flatulence
- fluid retention
- flushing
- galactorrhea
- gastritis
- gastroesophageal reflux
- GI bleeding
- GI obstruction
- hallucinations
- headache
- hearing loss
- hematemesis
- hematuria
- hemolytic anemia
- hiccups
- hyperacusis
- hyperesthesia
- hyperglycemia
- hyperhidrosis
- hypersalivation
- hypertension
- hypertensive crisis
- hyperthermia
- hypoglycemia
- hypotension
- hypothyroidism
- increased urinary frequency
- infection
- influenza
- injection site reaction
- intracranial bleeding
- keratitis
- lacrimation
- lymphadenopathy
- malaise
- melena
- memory impairment
- menstrual irregularity
- muscle cramps
- myalgia
- myasthenia
- mydriasis
- myocardial infarction
- myoclonia
- nausea
- nephrolithiasis
- ocular hemorrhage
- ocular irritation
- ocular pain
- ocular pruritus
- otalgia
- pallor
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- parosmia
- peptic ulcer
- peripheral vasoconstriction
- peripheral vasodilation
- phlebitis
- phobia
- photophobia
- photosensitivity
- polydipsia
- premature atrial contractions (PACs)
- premature ventricular contractions (PVCs)
- pruritus
- pulmonary embolism
- QT prolongation
- rash
- renal failure (unspecified)
- retinal thrombosis
- rhinalgia
- rhinitis
- rhinorrhea
- seborrhea
- seizures
- serotonin syndrome
- shivering
- sinus tachycardia
- sinusitis
- skin irritation
- spontaneous fetal abortion
- ST-T wave changes
- stroke
- suicidal ideation
- syncope
- tetany
- thrombocytopenia
- thrombosis
- tinnitus
- tremor
- urticaria
- vasculitis
- ventricular fibrillation
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weight gain
- weight loss
- withdrawal
- xerosis
- xerostomia
- yawning
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acute myocardial infarction
- angina
- arteriosclerosis
- basilar/hemiplegic migraine
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cerebrovascular disease
- children
- colitis
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- geriatric
- hepatic disease
- hypercholesterolemia
- hypertension
- intracranial bleeding
- intravenous administration
- latex hypersensitivity
- magnetic resonance imaging (MRI)
- MAOI therapy
- obesity
- peripheral vascular disease
- pregnancy
- Raynaud’s phenomenon
- renal disease
- renal failure
- renal impairment
- seizure disorder
- seizures
- stroke
- sumatriptan hypersensitivity
- tobacco smoking
- vasospastic angina
- visual disturbance
- Wolff-Parkinson-White syndrome
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Alfentanil
- Almotriptan
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Bromocriptine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butorphanol
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Citalopram
- Clomipramine
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Desipramine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Doxepin
- Droxidopa
- Duloxetine
- Eletriptan
- Ergot alkaloids
- Escitalopram
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Frovatriptan
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Imipramine
- Isocarboxazid
- Lasmiditan
- Levomilnacipran
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lithium
- Lorcaserin
- Meperidine
- Meperidine; Promethazine
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Milnacipran
- Mirtazapine
- Morphine
- Morphine; Naltrexone
- Nalbuphine
- Naratriptan
- Nefazodone
- Nortriptyline
- Oxycodone
- Oxymorphone
- Ozanimod
- Paroxetine
- Perphenazine; Amitriptyline
- Phenelzine
- Protriptyline
- Rasagiline
- Remifentanil
- Rizatriptan
- Selective serotonin reuptake inhibitors
- Selegiline
- Sertraline
- Sibutramine
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tapentadol
- Tedizolid
- Tramadol
- Tranylcypromine
- Trazodone
- Tricyclic antidepressants
- Trimipramine
- Venlafaxine
- Vilazodone
- Vortioxetine
- Zolmitriptan
