Sulconazole

What is Sulconazole

Sulconazole is an azole antifungal of the imidazole subgroup. It is used topically for a variety of fungal and yeast infections.

Sulconazole’s mechanism is largely fungistatic, however the in vitro antifungal spectrum is extremely broad.

Sulconazole is structurally related to and similarly effective for tinea infections as other imidazole-derivative azole antifungal agents such as clotrimazole, econazole, and miconazole.

In some studies of tinea pedis, sulconazole demonstrated a greater efficacy and onset of effect compared to miconazole and clotrimazole.

In the management of tinea cruris/corporis, sulconazole 1% cream applied once daily was as effective as twice daily application of clotrimazole 1% cream.

Brand Name

Exelderm

Indications

  1. Candida albicans
  2. Candida glabrata
  3. Candida guilliermondii
  4. Candida krusei
  5. Candida parapsilosis
  6. Candida pseudotropicalis
  7. Candida tropicalis
  8. candidiasis
  9. Epidermophyton floccosum
  10. Malassezia furfur
  11. Microsporum audouinii
  12. Microsporum canis
  13. Microsporum gypseum
  14. tinea corporis
  15. tinea cruris
  16. tinea pedis
  17. tinea versicolor
  18. Trichophyton mentagrophytes
  19. Trichophyton rubrum
  20. Trichophyton tonsurans
  21. Trichophyton violaceum

Side Effects

  • erythema
  • pruritus
  • skin irritation

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • azole antifungals hypersensitivity
  • breast-feeding
  • children
  • ocular exposure
  • onychomycosis
  • ophthalmic administration
  • pregnancy
  • vaginal administration

Interactions

  • Nystatin

Nystatin: (Moderate) The combination of sulconazole and nystatin represents duplication of therapy whenever the drugs are used by similar routes and are usually avoided.

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