Streptomycin

What is Streptomycin

Streptomycin is a parenteral aminoglycoside antibiotic derived from cultures of Streptomyces griseus. It was the first of the aminoglycosides to be isolated and used therapeutically.

Clinical use of streptomycin includes Mycobacterium tuberculosis infections (second- or third-line agent), tularemia (Francisella tularensis), plague (Yersinia pestis), and, until recently, in combination with a penicillin for the treatment of endocarditis.

Due to resistant organisms, a higher risk of irreversible vestibular toxicity, and the inability to monitor serum concentrations in most institutions, other aminoglycoside agents, such as gentamicin or tobramycin, are more desirable. Streptomycin was approved by the FDA in 1945.

Indications & Dosage

  1. Acinetobacter sp.
  2. Actinomadura madurae
  3. Actinomadura pelletierii
  4. actinomycotic mycetoma
  5. Bacillus anthracis
  6. bacteremia
  7. Brucella sp.
  8. brucellosis
  9. Burkholderia mallei
  10. chancroid
  11. Citrobacter sp.
  12. endocarditis
  13. Enterococcus faecalis
  14. Erysipelothrix sp.
  15. Escherichia coli
  16. Francisella tularensis
  17. granuloma inguinale
  18. Haemophilus ducreyi
  19. Haemophilus influenzae (beta-lactamase negative)
  20. Haemophilus influenzae (beta-lactamase positive)
  21. Klebsiella aerogenes
  22. Klebsiella granulomatis
  23. Klebsiella pneumoniae
  24. lower respiratory tract infections
  25. meningitis
  26. Mycobacterium avium
  27. Mycobacterium avium complex infection
  28. Mycobacterium bovis
  29. Mycobacterium intracellulare
  30. Mycobacterium kansasii
  31. Mycobacterium leprae
  32. Mycobacterium marinum
  33. Mycobacterium tuberculosis
  34. Nocardia brasiliensis
  35. Nocardia sp.
  36. Pasteurella multocida
  37. plague
  38. pneumonia
  39. Proteus sp.
  40. Providencia sp.
  41. Salmonella sp.
  42. Serratia sp.
  43. Shigella sp.
  44. Staphylococcus aureus (MSSA)
  45. Staphylococcus epidermidis
  46. Streptomyces somaliensis
  47. tuberculosis infection
  48. tularemia
  49. tularemia prophylaxis
  50. urinary tract infection (UTI)
  51. Viridans streptococci
  52. Yersinia pestis

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. amblyopia
  3. anaphylactoid reactions
  4. angioedema
  5. arachnoiditis
  6. azotemia
  7. cylindruria
  8. encephalopathy
  9. eosinophilia
  10. exfoliative dermatitis
  11. fever
  12. hearing loss
  13. hemolytic anemia
  14. hyposthenuria
  15. injection site reaction
  16. leukopenia
  17. nephrotoxicity
  18. neuritis
  19. neurotoxicity
  20. ototoxicity
  21. pancytopenia
  22. paresthesias
  23. proteinuria
  24. pyuria
  25. rash
  26. renal tubular acidosis (RTA)
  27. renal tubular necrosis
  28. thrombocytopenia
  29. tinnitus
  30. urticaria
  31. vitamin B12 deficiency
  32. vitamin B6 deficiency
  33. weakness

Monitoring Parameters

  • audiometry
  • serum creatinine/BUN

Contraindications

  • aminoglycoside hypersensitivity
  • botulism
  • breast-feeding
  • colitis
  • dehydration
  • diarrhea
  • geriatric
  • GI disease
  • hearing impairment
  • infants
  • inflammatory bowel disease
  • intravenous administration
  • myasthenia gravis
  • neonates
  • nephrotoxicity
  • neuromuscular blockade
  • neurotoxicity
  • ototoxicity
  • parkinsonism
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • requires a specialized care setting
  • respiratory depression
  • respiratory insufficiency
  • sexually transmitted disease
  • tinnitus
  • ulcerative colitis
  • viral infection

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Diphenhydramine
  • Acyclovir
  • Adefovir
  • Aldesleukin, IL-2
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Aprotinin
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Bacitracin
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Beractant
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bleomycin
  • Botulinum Toxins
  • Bumetanide
  • Calfactant
  • Capreomycin
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carboplatin
  • Cefepime
  • Cefotaxime
  • Cefotetan
  • Cefoxitin
  • Cefprozil
  • Ceftazidime
  • Ceftazidime; Avibactam
  • Ceftizoxime
  • Cefuroxime
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Choline Salicylate; Magnesium Salicylate
  • Cidofovir
  • Cisatracurium
  • Cisplatin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colfosceril; Cetyl Alcohol; Tyloxapol
  • Cyclizine
  • Cyclosporine
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Deferasirox
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxacurium
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enflurane
  • Entecavir
  • Ethacrynic Acid
  • Etomidate
  • Fluphenazine
  • Foscarnet
  • Fospropofol
  • Furosemide
  • Gallium
  • Gallium Ga 68 Dotatate
  • Ganciclovir
  • General anesthetics
  • Ginger, Zingiber officinale
  • Gold
  • Halothane
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibandronate
  • Ibuprofen lysine
  • Immune Globulin IV, IVIG, IGIV
  • Inotersen
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Isoflurane
  • Isosulfan Blue
  • Ketamine
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Magnesium Salicylate
  • Mannitol
  • Meclizine
  • Meperidine; Promethazine
  • Mesoridazine
  • Methohexital
  • Mivacurium
  • Neuromuscular blockers
  • Non-Ionic Contrast Media
  • Nonsteroidal antiinflammatory drugs
  • Oral Contraceptives
  • Pamidronate
  • Pancuronium
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenylephrine; Promethazine
  • Polymyxin B
  • Polymyxins
  • Poractant Alfa
  • Promethazine
  • Propofol
  • Pyridostigmine
  • Rapacuronium
  • Rocuronium
  • Salicylates
  • Salsalate
  • Scopolamine
  • Sevoflurane
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptozocin
  • Succinylcholine
  • Surfactants
  • Tacrolimus
  • Telavancin
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Thiopental
  • Thioridazine
  • Torsemide
  • Trifluoperazine
  • Trimethobenzamide
  • Tubocurarine
  • Urea
  • Valacyclovir
  • Valganciclovir
  • Vancomycin
  • Vecuronium
  • Vitamin C
  • Warfarin
  • Zalcitabine, ddC
  • Zoledronic Acid
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