Simeprevir

What is Simeprevir

Simeprevir is an NS3/4A protease inhibitor, indicated for the treatment of genotype 1 and 4 chronic hepatitis C virus (HCV) infection in adults greater than or equal to 18 years of age. 

Brand Name

Olysio

Indications

  • hepatitis C infection
  • hepatitis C virus

Side Effects

  • diarrhea
  • dizziness
  • dyspnea
  • fatigue
  • headache
  • hepatic failure
  • hepatitis B exacerbation
  • hyperamylasemia
  • hyperbilirubinemia
  • myalgia
  • nausea
  • photosensitivity
  • pruritus
  • rash

Monitoring Parameters

  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • pregnancy testing
  • serum bilirubin (total and direct)

Contraindications

  • anticoagulant therapy
  • Asian patients
  • breast-feeding
  • children
  • hepatic disease
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • infants
  • liver transplant
  • male-mediated teratogenicity
  • neonates
  • pregnancy
  • serious rash
  • sulfonamide hypersensitivity
  • sunlight (UV) exposure

Interactions

  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Afatinib
  • Aldesleukin, IL-2
  • Alfentanil
  • Alfuzosin
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alpelisib
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Armodafinil
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendamustine
  • Benzhydrocodone; Acetaminophen
  • Betrixaban
  • Bexarotene
  • Boceprevir
  • Bortezomib
  • Bosentan
  • Bosutinib
  • Brigatinib
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Cabozantinib
  • Caffeine; Ergotamine
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carvedilol
  • Ceritinib
  • Cerivastatin
  • Cevimeline
  • Chloramphenicol
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cilostazol
  • Cimetidine
  • Cinacalcet
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clonazepam
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Crizotinib
  • Cyclophosphamide
  • Cyclosporine
  • Dabigatran
  • Daclatasvir
  • Danazol
  • Dapsone
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dexamethasone
  • Dexlansoprazole
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Digoxin
  • Dihydroergotamine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Docetaxel
  • Dolasetron
  • Donepezil
  • Donepezil; Memantine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxorubicin
  • Dronedarone
  • Dutasteride; Tamsulosin
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eletriptan
  • Eliglustat
  • Eluxadoline
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Enzalutamide
  • Eplerenone
  • Ergotamine
  • Erlotinib
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Eslicarbazepine
  • Estazolam
  • Eszopiclone
  • Ethosuximide
  • Etravirine
  • Ezetimibe; Simvastatin
  • Fedratinib
  • Felbamate
  • Felodipine
  • Fentanyl
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Flutamide
  • Fluvastatin
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • Fostamatinib
  • Gemfibrozil
  • Glecaprevir; Pibrentasvir
  • Glyburide
  • Glyburide; Metformin
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Imatinib
  • Imipramine
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indinavir
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ixabepilone
  • Ketoconazole
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lapatinib
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Lemborexant
  • Letermovir
  • Lidocaine
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lovastatin
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
  • Lurasidone
  • Maraviroc
  • Mefloquine
  • Metformin; Repaglinide
  • Methadone
  • Methotrexate
  • Mexiletine
  • Midazolam
  • Mifepristone
  • Milk Thistle, Silybum marianum
  • Mitotane
  • Mitoxantrone
  • Modafinil
  • Morphine
  • Morphine; Naltrexone
  • Naldemedine
  • Nebivolol; Valsartan
  • Nefazodone
  • Nelfinavir
  • Neratinib
  • Nevirapine
  • Niacin; Simvastatin
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Obeticholic Acid
  • Octreotide
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Oritavancin
  • Osimertinib
  • Oxcarbazepine
  • Oxybutynin
  • Oxycodone
  • Paclitaxel
  • Paricalcitol
  • Pazopanib
  • Perampanel
  • Perindopril; Amlodipine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
  • Pimozide
  • Pitavastatin
  • Porfimer
  • Posaconazole
  • Pravastatin
  • Prednisolone
  • Prednisone
  • Primidone
  • Propafenone
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Repaglinide
  • Revefenacin
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Rifaximin
  • Ritonavir
  • Rivaroxaban
  • Ropinirole
  • Ropivacaine
  • Rosuvastatin
  • Sacubitril; Valsartan
  • Sapropterin
  • Saquinavir
  • Sertraline
  • Sibutramine
  • Sildenafil
  • Silodosin
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sirolimus
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Sorafenib
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfasalazine
  • Tadalafil
  • Tamsulosin
  • Telithromycin
  • Telotristat Ethyl
  • Temsirolimus
  • Teniposide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Teriflunomide
  • Theophylline, Aminophylline
  • Thiabendazole
  • Tiagabine
  • Ticagrelor
  • Tinidazole
  • Tipranavir
  • Tizanidine
  • Tolterodine
  • Topiramate
  • Topotecan
  • Tramadol
  • Trandolapril; Verapamil
  • Trazodone
  • Triamterene
  • Triazolam
  • Ubrogepant
  • Valsartan
  • Vemurafenib
  • Venetoclax
  • Verapamil
  • Verteporfin
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
  • Vorapaxar
  • Voriconazole
  • Warfarin
  • Zafirlukast
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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