Succimer

What is Succimer

Succimer is an oral chelating agent used to treat lead toxicity. Succimer works by forming water-soluble chelates with lead, which are excreted in the urine.

Succimer may have efficacy for lead encephalopathy and for other heavy metal poisoning such as mercury or arsenic poisoning; data are limited. Succimer was approved by the FDA in January 1991.

Brand Name

Chemet

Indications

  • lead toxicity

Side Effects

  1. abdominal pain
  2. angioedema
  3. anorexia
  4. arrhythmia exacerbation
  5. back pain
  6. chills
  7. cough
  8. diarrhea
  9. dizziness
  10. drowsiness
  11. dysuria
  12. elevated hepatic enzymes
  13. eosinophilia
  14. fatigue
  15. fever
  16. flank pain
  17. headache
  18. hemorrhoids
  19. hypercholesterolemia
  20. infection
  21. irritability
  22. lacrimation
  23. maculopapular rash
  24. metallic taste
  25. nasal congestion
  26. nausea
  27. neutropenia
  28. oral ulceration
  29. paresthesias
  30. peripheral neuropathy
  31. proteinuria
  32. pruritus
  33. rash
  34. rhinorrhea
  35. throat irritation
  36. thrombocytosis
  37. urinary retention
  38. urticaria
  39. vesicular rash
  40. vomiting

Monitoring Parameters

  • CBC with differential
  • LFTs
  • platelet count
  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • dehydration
  • dialysis
  • hepatic disease
  • hypovolemia
  • infants
  • neonates
  • neutropenia
  • pregnancy
  • renal failure
  • renal impairment

Interactions

  • Dimercaprol
  • Edetate Calcium Disodium, Calcium EDTA
  • Edetate Disodium, Disodium EDTA
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