Upadacitinib

What is Upadacitinib

Upadacitinib is an oral Janus kinase (JAK) inhibitor and is considered a targeted synthetic disease-modifying antirheumatic drug (tsDMARD).

Brand Name

RINVOQ

Indications

  • rheumatoid arthritis

Side Effects

  • abdominal pain
  • anemia
  • candidiasis
  • cough
  • elevated hepatic enzymes
  • fever
  • GI perforation
  • hepatotoxicity
  • hypercholesterolemia
  • hyperlipidemia
  • hypertriglyceridemia
  • infection
  • laryngitis
  • lymphoma
  • lymphopenia
  • nausea
  • neutropenia
  • new primary malignancy
  • pharyngitis
  • pulmonary embolism
  • rhinitis
  • sinusitis
  • skin cancer
  • thromboembolism
  • thrombosis

Monitoring Parameters

  • CBC with differential
  • hemoglobin/hematocrit
  • LFTs
  • serum cholesterol profile
  • skin cancer screening exam
  • tuberculin skin test

Contraindications

  • acquired immunodeficiency syndrome (AIDS)
  • anemia
  • breast-feeding
  • children
  • contraception requirements
  • corticosteroid therapy
  • diverticulitis
  • fungal infection
  • geriatric
  • GI perforation
  • hepatic disease
  • hepatitis
  • hepatitis B exacerbation
  • herpes infection
  • human immunodeficiency virus (HIV) infection
  • hypercholesterolemia
  • hyperlipidemia
  • immunosuppression
  • infants
  • infection
  • lymphoma
  • neutropenia
  • new primary malignancy
  • pregnancy
  • pregnancy testing
  • pulmonary disease
  • reproductive risk
  • skin cancer
  • thromboembolic disease
  • thromboembolism
  • thrombosis
  • tuberculosis
  • vaccination
  • viral infection

Interactions

  • Abatacept
  • Adalimumab
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anakinra
  • Antithymocyte Globulin
  • Apalutamide
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azathioprine
  • Baricitinib
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Brodalumab
  • Canakinumab
  • Carbamazepine
  • Ceritinib
  • Certolizumab pegol
  • Chloramphenicol
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Cyclosporine
  • Daclizumab
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enzalutamide
  • Etanercept
  • Everolimus
  • Fosamprenavir
  • Fosphenytoin
  • Golimumab
  • grapefruit juice
  • Guselkumab
  • Idelalisib
  • Indinavir
  • Infliximab
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ixekizumab
  • Ketoconazole
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Mercaptopurine, 6-MP
  • Mifepristone
  • Mitotane
  • Nefazodone
  • Nelfinavir
  • Ombitasvir; Paritaprevir; Ritonavir
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Ritonavir
  • Rituximab
  • Rituximab; Hyaluronidase
  • Ruxolitinib
  • Saquinavir
  • Sarilumab
  • Secukinumab
  • Sirolimus
  • St. John’s Wort, Hypericum perforatum
  • Tacrolimus
  • Telithromycin
  • Tipranavir
  • Tocilizumab
  • Tofacitinib
  • Tucatinib
  • Tumor Necrosis Factor modifiers
  • Ustekinumab
  • Voriconazole