What is Sofosbuvir and Velpatasvir medicine combination
Sofosbuvir and velpatasvir is a combination oral product indicated for the treatment of adults and pediatric patients 6 years and older weighing 17 kg or more infected with chronic hepatitis C virus (HCV), including genotypes 1, 2, 3, 4, 5, and 6.
Sofosbuvir and velpatasvir is the first drug approved for the treatment of all 6 HCV genotypes.
For patients without cirrhosis and those with compensated cirrhosis, the drug may be administered as a monotherapy; however, patients with decompensated cirrhosis must receive sofosbuvir; velpatasvir in combination with ribavirin.
Brand Name
Epclusa
Indications & Dosage
- hepatitis C infection
- hepatitis C virus
Side Effects
- anemia
- angioedema
- asthenia
- depression
- diarrhea
- fatigue
- headache
- hepatic failure
- hepatitis B exacerbation
- hyperbilirubinemia
- insomnia
- irritability
- nausea
- rash
Monitoring Parameters
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum creatinine/BUN
Contraindications
- anticoagulant therapy
- breast-feeding
- diabetes mellitus
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hyperglycemia
- hypoglycemia
- male-mediated teratogenicity
- pregnancy
Interactions
- Acalabrutinib
- Acarbose
- Acetohexamide
- Afatinib
- Albiglutide
- Aldesleukin, IL-2
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpelisib
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Antidiabetic Agents
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Aspirin, ASA; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Basiliximab
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betrixaban
- Bexarotene
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Boceprevir
- Bosentan
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Carbamazepine
- Carvedilol
- Cenobamate
- Chloramphenicol
- Chlorpropamide
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Cocaine
- Conivaptan
- Cyclosporine
- Dabrafenib
- Daclatasvir
- Danazol
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Dexamethasone
- Dexlansoprazole
- Dextromethorphan; Quinidine
- Digoxin
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Enzalutamide
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etravirine
- Exenatide
- Ezetimibe; Simvastatin
- Famotidine
- Famotidine; Ibuprofen
- Felbamate
- Felodipine
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- H2-blockers
- Hydroxyprogesterone
- Idelalisib
- Imatinib
- Indinavir
- Insulin Aspart
- Insulin Aspart; Insulin Aspart Protamine
- Insulin Degludec; Liraglutide
- Insulin Detemir
- Insulin Glargine
- Insulin Glargine; Lixisenatide
- Insulin Glulisine
- Insulin Lispro
- Insulin Lispro; Insulin Lispro Protamine
- Insulin, Inhaled
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isophane Insulin (NPH)
- Itraconazole
- Ivacaftor
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole
- Lansoprazole; Naproxen
- Lapatinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lente Insulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lixisenatide
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Magnesium Hydroxide
- Maraviroc
- Mefloquine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Mifepristone
- Miglitol
- Mitotane
- Modafinil
- Nafcillin
- Naldemedine
- Nateglinide
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nilotinib
- Nizatidine
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Osimertinib
- Ozanimod
- Pantoprazole
- Pazopanib
- Perampanel
- Perindopril; Amlodipine
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Pioglitazone
- Pirfenidone
- Posaconazole
- Pramlintide
- Primidone
- Propafenone
- Proton pump inhibitors
- Quinidine
- Quinine
- Rabeprazole
- Ranitidine
- Ranolazine
- Regular Insulin
- Regular Insulin; Isophane Insulin (NPH)
- Repaglinide
- Revefenacin
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rimegepant
- Rolapitant
- Rosiglitazone
- Rosuvastatin
- Sapropterin
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Semaglutide
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- Sitagliptin
- St. John’s Wort, Hypericum perforatum
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Tacrolimus
- Tafamidis
- Talazoparib
- Tedizolid
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Teriflunomide
- Testosterone
- Tezacaftor; Ivacaftor
- Thiotepa
- Ticagrelor
- Ticlopidine
- Tipranavir
- Tolazamide
- Tolbutamide
- Tolvaptan
- Topiramate
- Topotecan
- Trametinib
- Trandolapril; Verapamil
- Trimethoprim
- Ubrogepant
- Ultralente Insulin
- Valproic Acid, Divalproex Sodium
- Vemurafenib
- Venetoclax
- Verapamil
- Voriconazole
- Warfarin
- Zafirlukast
- Zonisamide
