Sofosbuvir Velpatasvir Voxilaprevir

What is Sofosbuvir Velpatasvir Voxilaprevir combination medicine

Sofosbuvir Velpatasvir Voxilaprevir is an oral fixed-dose combination antiviral indicated for the treatment of chronic hepatitis C virus (HCV) infection in certain treatment-experienced adults without cirrhosis or who have compensated cirrhosis (Child-Pugh A).

The drug is indicated for the treatment of HCV genotypes 1, 2, 3, 4, 5, and 6 infections in patients previously treated with an HCV regimen containing an NS5A inhibitor. 

Additionally, the drug may be used to treat HCV genotype 1a and 3 infections in patients previously treated with a sofosbuvir-containing HCV regimen that DID NOT include an NS5A inhibitor.

Additional benefit of sofosbuvir; velpatasvir; voxilaprevir over sofosbuvir; velpatasvir was not shown in adults with genotype 1b, 2, 4, 5, or 6 infection previously treated with sofosbuvir without an NS5A inhibitor.

Brand Name

Vosevi

Indications & Dosage

  • hepatitis C infection
  • hepatitis C virus

Side Effects

  1. angioedema
  2. asthenia
  3. diarrhea
  4. fatigue
  5. headache
  6. hepatic decompensation
  7. hepatic failure
  8. hepatitis B exacerbation
  9. hyperbilirubinemia
  10. insomnia
  11. nausea
  12. rash

Monitoring Parameters

  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • serum creatinine/BUN

Contraindications

  • alcoholism
  • anticoagulant therapy
  • ascites
  • breast-feeding
  • diabetes mellitus
  • hepatic decompensation
  • hepatic encephalopathy
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • hepatocellular cancer
  • hyperglycemia
  • hypoglycemia
  • jaundice
  • pregnancy

Interactions

  • Acalabrutinib
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  • Aldesleukin, IL-2
  • Aliskiren
  • Aliskiren; Amlodipine
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  • Aliskiren; Valsartan
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  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpelisib
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  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiodarone
  • Amlodipine
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  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
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