Sofosbuvir Velpatasvir Voxilaprevir

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What is Sofosbuvir Velpatasvir Voxilaprevir combination medicine

Sofosbuvir Velpatasvir Voxilaprevir is an oral fixed-dose combination antiviral indicated for the treatment of chronic hepatitis C virus (HCV) infection in certain treatment-experienced adults without cirrhosis or who have compensated cirrhosis (Child-Pugh A).

The drug is indicated for the treatment of HCV genotypes 1, 2, 3, 4, 5, and 6 infections in patients previously treated with an HCV regimen containing an NS5A inhibitor. 

Additionally, the drug may be used to treat HCV genotype 1a and 3 infections in patients previously treated with a sofosbuvir-containing HCV regimen that DID NOT include an NS5A inhibitor.

Additional benefit of sofosbuvir; velpatasvir; voxilaprevir over sofosbuvir; velpatasvir was not shown in adults with genotype 1b, 2, 4, 5, or 6 infection previously treated with sofosbuvir without an NS5A inhibitor.

Brand Name

Vosevi

Indications & Dosage

  • hepatitis C infection
  • hepatitis C virus

Side Effects

  1. angioedema
  2. asthenia
  3. diarrhea
  4. fatigue
  5. headache
  6. hepatic decompensation
  7. hepatic failure
  8. hepatitis B exacerbation
  9. hyperbilirubinemia
  10. insomnia
  11. nausea
  12. rash

Monitoring Parameters

  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • serum creatinine/BUN

Contraindications

  • alcoholism
  • anticoagulant therapy
  • ascites
  • breast-feeding
  • diabetes mellitus
  • hepatic decompensation
  • hepatic encephalopathy
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • hepatocellular cancer
  • hyperglycemia
  • hypoglycemia
  • jaundice
  • pregnancy

Interactions

  • Acalabrutinib
  • Acarbose
  • Acetohexamide
  • Afatinib
  • Albiglutide
  • Aldesleukin, IL-2
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpelisib
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiodarone
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Antacids
  • Antidiabetic Agents
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Armodafinil
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Basiliximab
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betrixaban
  • Bexarotene
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Boceprevir
  • Bosentan
  • Budesonide
  • Budesonide; Formoterol
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Canagliflozin
  • Canagliflozin; Metformin
  • Carbamazepine
  • Carvedilol
  • Cenobamate
  • Chloramphenicol
  • Chlorpropamide
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Cobicistat
  • Cobimetinib
  • Cocaine
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Cyclosporine
  • Dabigatran
  • Dabrafenib
  • Daclatasvir
  • Danazol
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Delavirdine
  • Dexamethasone
  • Dexlansoprazole
  • Dextromethorphan; Quinidine
  • Digoxin
  • Docetaxel
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxorubicin
  • Dronedarone
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dulaglutide
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eletriptan
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Eluxadoline
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Enzalutamide
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etravirine
  • Everolimus
  • Exenatide
  • Ezetimibe; Simvastatin
  • Famotidine
  • Famotidine; Ibuprofen
  • Felbamate
  • Felodipine
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flutamide
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvastatin
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • Glecaprevir; Pibrentasvir
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • grapefruit juice
  • H2-blockers
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydroxyprogesterone
  • Idelalisib
  • Imatinib
  • Indinavir
  • Insulin Aspart
  • Insulin Aspart; Insulin Aspart Protamine
  • Insulin Degludec; Liraglutide
  • Insulin Detemir
  • Insulin Glargine
  • Insulin Glargine; Lixisenatide
  • Insulin Glulisine
  • Insulin Lispro
  • Insulin Lispro; Insulin Lispro Protamine
  • Insulin, Inhaled
  • Irinotecan
  • Irinotecan Liposomal
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isophane Insulin (NPH)
  • Itraconazole
  • Ivacaftor
  • Ketoconazole
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lapatinib
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Lente Insulin
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Linagliptin
  • Linagliptin; Metformin
  • Liraglutide
  • Lixisenatide
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Magnesium Hydroxide
  • Maraviroc
  • Mefloquine
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methotrexate
  • Mifepristone
  • Miglitol
  • Mitomycin
  • Mitotane
  • Mitoxantrone
  • Modafinil
  • Morphine
  • Morphine; Naltrexone
  • Nafcillin
  • Naldemedine
  • Nateglinide
  • Nebivolol; Valsartan
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Niacin; Simvastatin
  • Nilotinib
  • Nizatidine
  • Obeticholic Acid
  • Octreotide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Ondansetron
  • Oritavancin
  • Osimertinib
  • Oxcarbazepine
  • Ozanimod
  • Paclitaxel
  • Panobinostat
  • Pantoprazole
  • Pazopanib
  • Perampanel
  • Perindopril; Amlodipine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
  • Pioglitazone
  • Pirfenidone
  • Pitavastatin
  • Posaconazole
  • Pramlintide
  • Pravastatin
  • Prednisone
  • Primidone
  • Propafenone
  • Proton pump inhibitors
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ranitidine
  • Ranolazine
  • Regular Insulin
  • Regular Insulin; Isophane Insulin (NPH)
  • Repaglinide
  • Revefenacin
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Rimegepant
  • Riociguat
  • Risperidone
  • Rivaroxaban
  • Rolapitant
  • Romidepsin
  • Rosiglitazone
  • Rosuvastatin
  • Sacubitril; Valsartan
  • Sapropterin
  • Saquinavir
  • Saxagliptin
  • Segesterone Acetate; Ethinyl Estradiol
  • Selexipag
  • Semaglutide
  • Silodosin
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sirolimus
  • Sitagliptin
  • St. John’s Wort, Hypericum perforatum
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Tacrolimus
  • Tafamidis
  • Talazoparib
  • Tedizolid
  • Telithromycin
  • Telotristat Ethyl
  • Temsirolimus
  • Teniposide
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Teriflunomide
  • Testosterone
  • Tezacaftor; Ivacaftor
  • Thiotepa
  • Ticagrelor
  • Ticlopidine
  • Tipranavir
  • Tolazamide
  • Tolbutamide
  • Tolvaptan
  • Topiramate
  • Topotecan
  • Trametinib
  • Trandolapril; Verapamil
  • Trimethoprim
  • Ubrogepant
  • Ultralente Insulin
  • Umeclidinium
  • Umeclidinium; Vilanterol
  • Valproic Acid, Divalproex Sodium
  • Valsartan
  • Vemurafenib
  • Venetoclax
  • Verapamil
  • Voriconazole
  • Warfarin
  • Zafirlukast
  • Zonisamide

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