Sofosbuvir

What is Sofosbuvir

Sofosbuvir is a nucleotide analog NS5B polymerase inhibitor approved for the treatment of chronic hepatitis C virus (HCV) infection in adults (genotypes 1, 2, 3, and 4) and pediatric patients 3 years and older (genotypes 2 and 3) without cirrhosis or with compensated hepatic disease.

The drug is also approved to treat HCV infection in patients with hepatocellular carcinoma who are awaiting liver transplant and in patients who are coinfected with HIV.

In some patients, treatment with sofosbuvir may preclude the need for concomitant interferon therapy; however, monotherapy is NOT recommended.

The product labeling contains a Black Box Warning regarding reactivation of hepatitis B virus (HBV) infection in HCV/HBV coinfected patients who receive sofosbuvir without concurrent HBV therapy.

All potential recipients of sofosbuvir should be tested for evidence of current or prior HBV infection before initiating treatment.

Brand Name

Sovaldi

Indications & Dosage

  • hepatitis C infection
  • hepatitis C virus

Side Effects

  1. anemia
  2. angioedema
  3. anorexia
  4. asthenia
  5. chills
  6. depression
  7. diarrhea
  8. fatigue
  9. fever
  10. headache
  11. hepatic failure
  12. hepatitis B exacerbation
  13. hyperbilirubinemia
  14. insomnia
  15. irritability
  16. myalgia
  17. nausea
  18. neutropenia
  19. pruritus
  20. rash
  21. weakness

Monitoring Parameters

  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • pregnancy testing
  • serum creatinine

Contraindications

  • anticoagulant therapy
  • breast-feeding
  • contraception requirements
  • diabetes mellitus
  • hepatic disease
  • hepatitis B exacerbation
  • hepatitis C and HIV coinfection
  • hyperglycemia
  • hypoglycemia
  • male-mediated teratogenicity
  • pregnancy
  • pregnancy testing
  • renal failure
  • renal impairment
  • reproductive risk

Interactions

  • Acalabrutinib
  • Acarbose
  • Acetohexamide
  • Albiglutide
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Amiodarone
  • Antidiabetic Agents
  • Apalutamide
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Canagliflozin
  • Canagliflozin; Metformin
  • Carbamazepine
  • Carvedilol
  • Chlorpropamide
  • Cobicistat
  • Conivaptan
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dulaglutide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Exenatide
  • Fosamprenavir
  • Fosphenytoin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Insulin Aspart
  • Insulin Aspart; Insulin Aspart Protamine
  • Insulin Degludec; Liraglutide
  • Insulin Detemir
  • Insulin Glargine
  • Insulin Glargine; Lixisenatide
  • Insulin Glulisine
  • Insulin Lispro
  • Insulin Lispro; Insulin Lispro Protamine
  • Insulin, Inhaled
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isophane Insulin (NPH)
  • Itraconazole
  • Lente Insulin
  • Linagliptin
  • Linagliptin; Metformin
  • Liraglutide
  • Lixisenatide
  • Lumacaftor; Ivacaftor
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Miglitol
  • Nateglinide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Osimertinib
  • Phenobarbital
  • Phenytoin
  • Pioglitazone
  • Pramlintide
  • Primidone
  • Regular Insulin
  • Regular Insulin; Isophane Insulin (NPH)
  • Repaglinide
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rolapitant
  • Rosiglitazone
  • Sapropterin
  • Saxagliptin
  • Semaglutide
  • Simeprevir
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • St. John’s Wort, Hypericum perforatum
  • Tafamidis
  • Tedizolid
  • Tipranavir
  • Tolazamide
  • Tolbutamide
  • Ultralente Insulin
  • Warfarin
  • Zonisamide
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