Sodium Bicarbonate

What is Sodium Bicarbonate

Sodium bicarbonate is a systemic alkalinizing agent. It most often is administered IV in the treatment of metabolic and respiratory acidosis.

Sodium bicarbonate is also used in the acute treatment of hyperkalemia, although it should be kept in mind that this represents palliative treatment for this condition.

Sodium bicarbonate is sometimes used for urinary alkalinization. Despite being a highly effective antacid, sodium bicarbonate is rarely used for the chronic treatment of peptic ulcer disease because it can be absorbed and can affect systemic acid-base balance. Sodium bicarbonate was in use prior to 1938 and approved by the FDA at its inception.

Brand Names

  • Alka-Seltzer Heartburn Relief
  • Baros
  • Neut

Indications & Dosage

  • cardiac arrest
  • cardiopulmonary resuscitation
  • dyspepsia
  • hyperkalemia
  • metabolic acidosis
  • pyrosis (heartburn)
  • urinary alkalinization

For the treatment of metabolic acidosis

for metabolic or respiratory acidosis during cardiopulmonary resuscitation (CPR) (cardiac arrest)

NOTE: Sodium bicarbonate is NOT recommended for routine use in cardiac arrest patients. Bicarbonate therapy should be considered during cardiac arrest only after confirmed interventions (i.e. defibrillation, cardiac compression, intubation, ventilation, epinephrine) have been used, unless the patient has known preexisting hyper-kalemia.

Side Effects

  • abdominal pain
  • flatulence
  • hypernatremia
  • injection site reaction
  • lactic acidosis
  • metabolic alkalosis
  • peripheral edema
  • seizures
  • tetany
  • tremor

Monitoring Parameters

  • arterial blood gases (ABGs)
  • serum sodium
  • total CO2

Contraindications

  • Bartter’s syndrome
  • breast-feeding
  • children
  • Cushing’s syndrome
  • heart failure
  • hyperaldosteronism
  • hypernatremia
  • hypocalcemia
  • hypokalemia
  • infants
  • metabolic alkalosis
  • neonates
  • pregnancy
  • renal disease
  • respiratory alkalosis

Interactions

  • Acalabrutinib
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acrivastine; Pseudoephedrine
  • Amlodipine; Atorvastatin
  • Amphetamines
  • Anticholinergics
  • Ascorbic Acid, Vitamin C
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Bempedoic Acid; Ezetimibe
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Bisacodyl
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisphosphonates
  • Bosutinib
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cefditoren
  • Cefpodoxime
  • Cefuroxime
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Choline Salicylate; Magnesium Salicylate
  • Chromium
  • Ciprofloxacin
  • Colchicine
  • Colchicine; Probenecid
  • Cysteamine
  • Dabrafenib
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Delavirdine
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dicyclomine
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Naproxen
  • Dirithromycin
  • Dolutegravir; Rilpivirine
  • Donepezil; Memantine
  • Eltrombopag
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Ephedrine
  • Erlotinib
  • Esomeprazole; Naproxen
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethotoin
  • Ezetimibe
  • Ezetimibe; Simvastatin
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Flavoxate
  • Flecainide
  • food
  • Fosamprenavir
  • Gabapentin
  • Gastrointestinal Enzymes
  • Gefitinib
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Halofantrine
  • Hetastarch; Dextrose; Electrolytes
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxychloroquine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Pseudoephedrine
  • Indacaterol; Glycopyrrolate
  • Indomethacin
  • Iron
  • Iron Salts
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Lactulose
  • Lansoprazole; Naproxen
  • Ledipasvir; Sofosbuvir
  • Lithium
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Magnesium Salicylate
  • Mefenamic Acid
  • Mefloquine
  • Memantine
  • Mepenzolate
  • Mesalamine, 5-ASA
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Methylphenidate
  • Mexiletine
  • Mycophenolate
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Neratinib
  • Nilotinib
  • Nitrofurantoin
  • Norfloxacin
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oxybutynin
  • Pancrelipase
  • Pazopanib
  • Penicillamine
  • Phenytoin
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Polysaccharide-Iron Complex
  • Ponatinib
  • Propantheline
  • Propranolol
  • Pseudoephedrine
  • Quinidine
  • Quinine
  • Rifampin
  • Rilpivirine
  • Ritonavir
  • Rosuvastatin
  • Salsalate
  • Scopolamine
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sodium Fluoride
  • Sodium Polystyrene Sulfonate
  • Sotalol
  • Sucralfate
  • Tacrolimus
  • Tetracyclines
  • Thiothixene
  • Ticlopidine
  • Tolmetin
  • Trihexyphenidyl
  • Trospium
  • Valproic Acid, Divalproex Sodium
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top