Sodium Hyaluronate Hyaluronic Acid Lidocaine

What is Sodium Hyaluronate Hyaluronic Acid Lidocaine

Sodium hyaluronate, hyaluronic acid; lidocaine is a sterile gel of hyaluronic acid generated by Streptococcus bacteria, which has been chemically cross-linked with 1,4-butanediol diglycidyl ether (BDDE) and formulated with 0.3% lidocaine.

The drug is classified as an injectable dermal filler, and is FDA approved for use in patients 22 years and older to correct age-related midface contour deficiencies (cheek augmentation), upper perioral rhytids, lip augmentation, and to correct volume deficits in the back of hands (hand augmentation).

Sodium hyaluronate, hyaluronic acid; lidocaine is also indicated for the correction of moderate to severe facial folds and wrinkles, such as nasolabial folds.

Indications & Dosage

  • facial wrinkles

For the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds

Side Effects

The most frequently reported adverse reaction to sodium hyaluronate, hyaluronic acid; lidocaine is an injection site reaction. These reactions consist mainly of mild to moderate inflammatory symptoms that last for 2 weeks or less.

Pooled data from clinical trials found the incidence of specific injection site reactions reported by patients to be 60% to 82% for bruising, 70% to 90% for edema, 56.7% to 79% for erythema, 26.7% to 34% for pruritus, 46.7% to 79% for pain, and 83.3% to 95% for tenderness.

Other symptoms reported by drug recipients included acne (5%), lumpiness (5%), red or purple mark (5%), and ecchymosis (13.3%). Physician diagnosed adverse events at the injection site included hematoma or bruising (8% to 18%), bleeding (5% to 7%), mass formation (0.8% to 2.5%), pain (5% to 9%), and edema (3% to 8%).

Injection site reactions reported during postmarketing use include skin discoloration, scarring, and ischemia. Most cases of discoloration were hyperpigmentation, sometimes described as blue to brown color ranging form mild to severe. Discoloration may occur within the same day as treatment or up to 6 months post-treatment. edema

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • amide local anesthetic hypersensitivity
  • anticoagulant therapy
  • aplastic anemia
  • breast-feeding
  • children
  • coagulopathy
  • hemophilia
  • immunosuppression
  • infants
  • infection
  • inflammation
  • intraarterial administration
  • intravenous administration
  • neonates
  • pregnancy
  • sunlight (UV) exposure
  • thrombocytopenia

Interactions

No information is available regarding drug interactions associated with Sodium Hyaluronate, Hyaluronic Acid

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