Sodium Fluoride

What is Sodium Fluoride

Sodium fluoride can be administered orally or topically to provide a source of fluoride, an important mineral.

Fluoride is the ionic form of fluorine. The negatively charged fluoride combines with positively charged calcium or sodium ions to form stable compounds. Topical fluorides, such as toothpastes, mouthrinses, gels, and foams, strengthen teeth already present in the mouth making them more decay-resistant.

Systemic fluorides, such as tablets, fluoridated water, lozenges, and drops, are ingested, incorporated into forming teeth, and distributed into saliva, which continually bathes the teeth. Although water contains fluoride ions, natural water in some areas has a very low concentration of fluoride. Fluoride reduces cavity development in both children and adults. 

Fluoride also helps repair the early stages of tooth decay even before the decay becomes visible. Sodium fluoride can increase bone density and thus, has been investigated in the management of postmenopausal osteoporosis.

Other possible uses include metabolic and neoplastic bone diseases, multiple myeloma, otosclerosis, and metastatic prostate carcinoma. Sodium fluoride was approved by the FDA in 1945.

Indications & Dosage

  • bone pain
  • dental caries prophylaxis
  • dentin desensitization
  • multiple myeloma
  • nutritional supplementation
  • osteoporosis
  • otosclerosis
  • prostate cancer

For nutritional supplementation in healthy individuals; a recommended daily allowance (RDA) has not been established; the adequate intake (AI) is used in place of RDA, as listed

Side Effects

  1. abdominal pain
  2. anemia
  3. asthenia
  4. atopic dermatitis
  5. dental fluorosis
  6. exfoliative dermatitis
  7. GI bleeding
  8. hematemesis
  9. hypersalivation
  10. nausea
  11. stomatitis
  12. synovitis
  13. urticaria
  14. vomiting
  15. weight loss

Monitoring Parameters

  • laboratory monitoring not necessary


  • arthralgia
  • breast-feeding
  • children
  • dental fluorosis
  • dental work
  • GI disease
  • infants
  • neonates
  • pregnancy
  • renal impairment
  • rheumatoid arthritis
  • tartrazine dye hypersensitivity
  • uremia


  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Chromium
  • Ethanol
  • food
  • Hetastarch; Dextrose; Electrolytes
  • Magnesium
  • Omeprazole; Sodium Bicarbonate
  • Sodium Bicarbonate
  • Trientine

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