Sertaconazole

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What is Sertaconazole

Sertaconazole is an imidazole-type antifungal used for the treatment of interdigital tinea pedis in immunocompetent patients.

Diagnosis of the disease should be confirmed either by direct microscopic evaluation of infected superficial epidermal tissue in a solution of potassium hydroxide (KOH preparation) or by culture on an appropriate medium. Relief of symptoms is usually seen within 7—14 days.

The duration of therapy is typically 4 weeks. Sertaconazole is not indicated for ophthalmic, oral, intravenous, or intravaginal use.

Sertaconazole 2% cream (Ertaczo™) is a prescription product which was approved by the FDA in December 2003.

Brand Name

Ertaczo

Indications & Dosage

  • Epidermophyton floccosum
  • tinea pedis
  • Trichophyton mentagrophytes
  • Trichophyton rubrum

Per the manufacturer, this drug has been shown to be active against most strains of the following microorganisms either in vitro and/or in clinical infectionsEpidermophyton floccosumTrichophyton mentagrophytesTrichophyton rubrum

NOTE: The safety and effectiveness in treating clinical infections due to organisms with in vitro data only have not been established in adequate and well-controlled clinical trials.

For the topical treatment of interdigital tinea pedis in immunocompetent patients

Side Effects

  • contact dermatitis
  • erythema
  • pruritus
  • skin hyperpigmentation
  • skin irritation
  • vesicular rash
  • xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • azole antifungals hypersensitivity
  • breast-feeding
  • children
  • geriatric
  • infants
  • neonates
  • onychomycosis
  • pregnancy

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • azole antifungals hypersensitivity
  • breast-feeding
  • children
  • geriatric
  • infants
  • neonates
  • onychomycosis
  • pregnancy

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • azole antifungals hypersensitivity
  • breast-feeding
  • children
  • geriatric
  • infants
  • neonates
  • onychomycosis
  • pregnancy

Interactions

  • Nystatin

Nystatin: (Moderate) The combination of sertaconazole and nystatin represent duplication of therapy whenever the drugs are used by similar route, and is usually avoided.

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