Sertraline

What is Sertraline

Sertraline is an oral selective serotonin reuptake inhibitor (SSRI) indicated for major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder in adults.

Sertraline has been used to treat depression and agitation in dementia patients. Other off-label uses in adults include generalized anxiety disorder, hot flashes, and premature ejaculation.

Sertraline is also indicated for treating OCD in pediatric patients 6 years and older.

Brand Name

Zoloft

Indications & Dosage

  • depression
  • generalized anxiety disorder (GAD)
  • hot flashes
  • menopause
  • obsessive-compulsive disorder (OCD)
  • panic disorder
  • posttraumatic stress disorder (PTSD)
  • premature ejaculation
  • premenstrual dysphoric disorder (PMDD)
  • pruritus
  • separation anxiety disorder
  • social phobia (social anxiety disorder)

For the treatment of major depression

Side Effects

  1. abnormal dreams
  2. agitation
  3. agranulocytosis
  4. akathisia
  5. alopecia
  6. anaphylactoid reactions
  7. angioedema
  8. anxiety
  9. aplastic anemia
  10. appetite stimulation
  11. arthralgia
  12. ataxia
  13. AV block
  14. bleeding
  15. blurred vision
  16. bone fractures
  17. bradycardia
  18. bronchospasm
  19. bullous rash
  20. cataracts
  21. coma
  22. confusion
  23. constipation
  24. depression
  25. diabetes mellitus
  26. diarrhea
  27. dizziness
  28. drowsiness
  29. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  30. dyspepsia
  31. dystonic reaction
  32. ecchymosis
  33. edema
  34. ejaculation dysfunction
  35. elevated hepatic enzymes
  36. epistaxis
  37. euphoria
  38. fatigue
  39. fever
  40. galactorrhea
  41. GI bleeding
  42. growth inhibition
  43. gynecomastia
  44. hallucinations
  45. headache
  46. hematoma
  47. hematuria
  48. hepatic failure
  49. hepatitis
  50. hyperactivity
  51. hypercholesterolemia
  52. hyperglycemia
  53. hyperhidrosis
  54. hyperkinesis
  55. hyperprolactinemia
  56. hypertension
  57. hypoesthesia
  58. hypoglycemia
  59. hyponatremia
  60. hypothyroidism
  61. impotence (erectile dysfunction)
  62. insomnia
  63. irritability
  64. jaundice
  65. lethargy
  66. leukopenia
  67. libido decrease
  68. lupus-like symptoms
  69. maculopapular rash
  70. malaise
  71. mania
  72. melena
  73. menstrual irregularity
  74. muscle cramps
  75. mydriasis
  76. nausea
  77. neonatal abstinence syndrome
  78. nightmares
  79. nocturia
  80. ocular hypertension
  81. optic neuritis
  82. orgasm dysfunction
  83. osteopenia
  84. palpitations
  85. pancreatitis
  86. pancytopenia
  87. peripheral vasodilation
  88. persistent pulmonary hypertension of the newborn
  89. petechiae
  90. photosensitivity
  91. platelet dysfunction
  92. priapism
  93. pruritus
  94. psychosis
  95. pulmonary hypertension
  96. purpura
  97. QT prolongation
  98. renal failure (unspecified)
  99. rhabdomyolysis
  100. seizures
  101. serotonin syndrome
  102. serum sickness
  103. SIADH
  104. sinus tachycardia
  105. Stevens-Johnson syndrome
  106. suicidal ideation
  107. syncope
  108. teeth grinding (bruxism)
  109. thrombocytopenia
  110. tinnitus
  111. torsade de pointes
  112. toxic epidermal necrolysis
  113. tremor
  114. trismus
  115. urinary incontinence
  116. urticaria
  117. vaginal bleeding
  118. vasculitis
  119. ventricular tachycardia
  120. visual impairment
  121. vomiting
  122. weight loss
  123. withdrawal
  124. xerostomia
  125. yawning

Monitoring Parameters

  • blood pressure
  • growth rate
  • heart rate
  • thyroid function tests (TFTs)
  • weight

Contraindications

  • abrupt discontinuation
  • akathisia
  • alcoholism
  • anorexia nervosa
  • anticoagulant therapy
  • bipolar disorder
  • bleeding
  • bone fractures
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • closed-angle glaucoma
  • coronary artery disease
  • dehydration
  • driving or operating machinery
  • electroconvulsive therapy (ECT)
  • ethanol ingestion
  • females
  • geriatric
  • growth inhibition
  • heart failure
  • hepatic disease
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypovolemia
  • increased intraocular pressure
  • long QT syndrome
  • malnutrition
  • mania
  • MAOI therapy
  • myocardial infarction
  • neonates
  • osteoporosis
  • pregnancy
  • QT prolongation
  • seizure disorder
  • suicidal ideation
  • thrombolytic therapy
  • thyroid disease

Interactions

  • Abciximab
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Alfuzosin
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Almotriptan
  • Alprazolam
  • Alteplase
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamines
  • Anagrelide
  • Antithrombin III
  • Apixaban
  • Apomorphine
  • Ardeparin
  • Arformoterol
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Azilsartan; Chlorthalidone
  • Azithromycin
  • Barbiturates
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bepridil
  • Betrixaban
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Brexpiprazole
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide; Formoterol
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Caffeine; Ergotamine
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cangrelor
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Ceritinib
  • Cevimeline
  • Chloroquine
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Class IC Antiarrhythmics
  • Clofazimine
  • Clomipramine
  • Clopidogrel
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Cyclosporine
  • Cyproheptadine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasatinib
  • Degarelix
  • Delavirdine
  • Desflurane
  • Desipramine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dipyridamole
  • Disopyramide
  • Disulfiram
  • Diuretics
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doxepin
  • Doxercalciferol
  • Dronedarone
  • Droperidol
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elbasvir; Grazoprevir
  • Eletriptan
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Encorafenib
  • Enflurane
  • Enoxaparin
  • Entrectinib
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eptifibatide
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Ethacrynic Acid
  • Ezogabine
  • Fenofibric Acid
  • Fentanyl
  • Fingolimod
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • Fondaparinux
  • Formoterol
  • Formoterol; Mometasone
  • Foscarnet
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Frovatriptan
  • Furosemide
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Glasdegib
  • Glycopyrrolate; Formoterol
  • Goserelin
  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Inotuzumab Ozogamicin
  • Isocarboxazid
  • Isoflurane
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ivacaftor
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lasmiditan
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levofloxacin
  • Levomilnacipran
  • Linezolid
  • Lithium
  • Lofexidine
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorcaserin
  • Low Molecular Weight Heparins
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Macimorelin
  • Magnesium Salicylate
  • Maprotiline
  • Mefloquine
  • Meperidine
  • Meperidine; Promethazine
  • Mesoridazine
  • Methadone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methyclothiazide
  • Methylene Blue
  • Methylergonovine
  • Methylphenidate
  • Methysergide
  • Metoclopramide
  • Metolazone
  • Metronidazole
  • Mexiletine
  • Midostaurin
  • Mifepristone
  • Milnacipran
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Modafinil
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Nilotinib
  • Nitroglycerin
  • Nonsteroidal antiinflammatory drugs
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olodaterol
  • Omeprazole; Amoxicillin; Rifabutin
  • Ondansetron
  • Oritavancin
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxycodone
  • Ozanimod
  • Paliperidone
  • Palonosetron
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pentamidine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentosan
  • Pergolide
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pitolisant
  • Posaconazole
  • Prasugrel
  • Primaquine
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Reteplase, r-PA
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rilpivirine
  • Risperidone
  • Rivaroxaban
  • Rizatriptan
  • Rolapitant
  • Romidepsin
  • Safinamide
  • Salmeterol
  • Salsalate
  • Saquinavir
  • Selegiline
  • Selpercatinib
  • Sevoflurane
  • Short-acting beta-agonists
  • Sibutramine
  • Simeprevir
  • Siponimod
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptokinase
  • Sumatriptan
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Tamsulosin
  • Tapentadol
  • Tedizolid
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Tenecteplase
  • Terbinafine
  • Tetrabenazine
  • Tezacaftor; Ivacaftor
  • Thioridazine
  • Thrombin Inhibitors
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tiotropium; Olodaterol
  • Tipranavir
  • Tirofiban
  • Tolterodine
  • Topiramate
  • Toremifene
  • Torsemide
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triamterene
  • Trifluoperazine
  • Trimipramine
  • Triptorelin
  • Umeclidinium; Vilanterol
  • Urokinase
  • Valerian, Valeriana officinalis
  • Vandetanib
  • Vardenafil
  • Vasopressin, ADH
  • Vemurafenib
  • Venlafaxine
  • Vilazodone
  • Vorapaxar
  • Voriconazole
  • Vorinostat
  • Vortioxetine
  • Warfarin
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
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