What is Sertraline
Sertraline is an oral selective serotonin reuptake inhibitor (SSRI) indicated for major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder in adults.
Sertraline has been used to treat depression and agitation in dementia patients. Other off-label uses in adults include generalized anxiety disorder, hot flashes, and premature ejaculation.
Sertraline is also indicated for treating OCD in pediatric patients 6 years and older.
Brand Name
Zoloft
Indications & Dosage
- depression
- generalized anxiety disorder (GAD)
- hot flashes
- menopause
- obsessive-compulsive disorder (OCD)
- panic disorder
- posttraumatic stress disorder (PTSD)
- premature ejaculation
- premenstrual dysphoric disorder (PMDD)
- pruritus
- separation anxiety disorder
- social phobia (social anxiety disorder)
For the treatment of major depression
Side Effects
- abnormal dreams
- agitation
- agranulocytosis
- akathisia
- alopecia
- anaphylactoid reactions
- angioedema
- anxiety
- aplastic anemia
- appetite stimulation
- arthralgia
- ataxia
- AV block
- bleeding
- blurred vision
- bone fractures
- bradycardia
- bronchospasm
- bullous rash
- cataracts
- coma
- confusion
- constipation
- depression
- diabetes mellitus
- diarrhea
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspepsia
- dystonic reaction
- ecchymosis
- edema
- ejaculation dysfunction
- elevated hepatic enzymes
- epistaxis
- euphoria
- fatigue
- fever
- galactorrhea
- GI bleeding
- growth inhibition
- gynecomastia
- hallucinations
- headache
- hematoma
- hematuria
- hepatic failure
- hepatitis
- hyperactivity
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hyperkinesis
- hyperprolactinemia
- hypertension
- hypoesthesia
- hypoglycemia
- hyponatremia
- hypothyroidism
- impotence (erectile dysfunction)
- insomnia
- irritability
- jaundice
- lethargy
- leukopenia
- libido decrease
- lupus-like symptoms
- maculopapular rash
- malaise
- mania
- melena
- menstrual irregularity
- muscle cramps
- mydriasis
- nausea
- neonatal abstinence syndrome
- nightmares
- nocturia
- ocular hypertension
- optic neuritis
- orgasm dysfunction
- osteopenia
- palpitations
- pancreatitis
- pancytopenia
- peripheral vasodilation
- persistent pulmonary hypertension of the newborn
- petechiae
- photosensitivity
- platelet dysfunction
- priapism
- pruritus
- psychosis
- pulmonary hypertension
- purpura
- QT prolongation
- renal failure (unspecified)
- rhabdomyolysis
- seizures
- serotonin syndrome
- serum sickness
- SIADH
- sinus tachycardia
- Stevens-Johnson syndrome
- suicidal ideation
- syncope
- teeth grinding (bruxism)
- thrombocytopenia
- tinnitus
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- trismus
- urinary incontinence
- urticaria
- vaginal bleeding
- vasculitis
- ventricular tachycardia
- visual impairment
- vomiting
- weight loss
- withdrawal
- xerostomia
- yawning
Monitoring Parameters
- blood pressure
- growth rate
- heart rate
- thyroid function tests (TFTs)
- weight
Contraindications
- abrupt discontinuation
- akathisia
- alcoholism
- anorexia nervosa
- anticoagulant therapy
- bipolar disorder
- bleeding
- bone fractures
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- closed-angle glaucoma
- coronary artery disease
- dehydration
- driving or operating machinery
- electroconvulsive therapy (ECT)
- ethanol ingestion
- females
- geriatric
- growth inhibition
- heart failure
- hepatic disease
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypovolemia
- increased intraocular pressure
- long QT syndrome
- malnutrition
- mania
- MAOI therapy
- myocardial infarction
- neonates
- osteoporosis
- pregnancy
- QT prolongation
- seizure disorder
- suicidal ideation
- thrombolytic therapy
- thyroid disease
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Alfuzosin
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alprazolam
- Alteplase
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamines
- Anagrelide
- Antithrombin III
- Apixaban
- Apomorphine
- Ardeparin
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir; Cobicistat
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Azilsartan; Chlorthalidone
- Azithromycin
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bepridil
- Betrixaban
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Brexpiprazole
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide; Formoterol
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Caffeine; Ergotamine
- Candesartan; Hydrochlorothiazide, HCTZ
- Cangrelor
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Ceritinib
- Cevimeline
- Chloroquine
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Cilostazol
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Class IC Antiarrhythmics
- Clofazimine
- Clomipramine
- Clopidogrel
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Crizotinib
- Cyclobenzaprine
- Cyclosporine
- Cyproheptadine
- Dabigatran
- Dalteparin
- Danaparoid
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasatinib
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Desmopressin
- Desvenlafaxine
- Deutetrabenazine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Dipyridamole
- Disopyramide
- Disulfiram
- Diuretics
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Doxercalciferol
- Dronedarone
- Droperidol
- Duloxetine
- Dutasteride; Tamsulosin
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Enoxaparin
- Entrectinib
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Ezogabine
- Fenofibric Acid
- Fentanyl
- Fingolimod
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Frovatriptan
- Furosemide
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Heparin
- Histrelin
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Inotuzumab Ozogamicin
- Isocarboxazid
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivacaftor
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lasmiditan
- Lefamulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levofloxacin
- Levomilnacipran
- Linezolid
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorcaserin
- Low Molecular Weight Heparins
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Macimorelin
- Magnesium Salicylate
- Maprotiline
- Mefloquine
- Meperidine
- Meperidine; Promethazine
- Mesoridazine
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methyclothiazide
- Methylene Blue
- Methylergonovine
- Methylphenidate
- Methysergide
- Metoclopramide
- Metolazone
- Metronidazole
- Mexiletine
- Midostaurin
- Mifepristone
- Milnacipran
- Mirabegron
- Mirtazapine
- Mitotane
- Modafinil
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Naproxen; Sumatriptan
- Naratriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Nitroglycerin
- Nonsteroidal antiinflammatory drugs
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxycodone
- Ozanimod
- Paliperidone
- Palonosetron
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentosan
- Pergolide
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phentermine
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pitolisant
- Posaconazole
- Prasugrel
- Primaquine
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Rasagiline
- Remifentanil
- Reteplase, r-PA
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rilpivirine
- Risperidone
- Rivaroxaban
- Rizatriptan
- Rolapitant
- Romidepsin
- Safinamide
- Salmeterol
- Salsalate
- Saquinavir
- Selegiline
- Selpercatinib
- Sevoflurane
- Short-acting beta-agonists
- Sibutramine
- Simeprevir
- Siponimod
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sorafenib
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptokinase
- Sumatriptan
- Sunitinib
- Tacrolimus
- Tamoxifen
- Tamsulosin
- Tapentadol
- Tedizolid
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Tenecteplase
- Terbinafine
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Thioridazine
- Thrombin Inhibitors
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tiotropium; Olodaterol
- Tipranavir
- Tirofiban
- Tolterodine
- Topiramate
- Toremifene
- Torsemide
- Tramadol
- Tranylcypromine
- Trazodone
- Triamterene
- Trifluoperazine
- Trimipramine
- Triptorelin
- Umeclidinium; Vilanterol
- Urokinase
- Valerian, Valeriana officinalis
- Vandetanib
- Vardenafil
- Vasopressin, ADH
- Vemurafenib
- Venlafaxine
- Vilazodone
- Vorapaxar
- Voriconazole
- Vorinostat
- Vortioxetine
- Warfarin
- Ziprasidone
- Zolmitriptan
- Zolpidem
