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What is Sargramostim (GM CSF)
Sargramostim is a recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF). It works by promoting proliferation and differentiation of hematopoietic progenitor cells.
Sargramostim is used as primary prophylaxis following induction therapy in older patients with acute myelogenous leukemia; for peripheral blood stem cell (PBSC) mobilization for collection by leukapheresis; following an autologous bone marrow transplantation (BMT) in patients with non-Hodgkin’s lymphoma, acute lymphoblastic leukemia, and Hodgkin’s disease; following an allogeneic BMT from an HLA-matched related donor; and following engraftment failure or delay after an autologous or allogeneic BMT.
Brand Name
Leukine
Indications & Dosage
- aplastic anemia
- chemotherapy-induced neutropenia
- ganciclovir-induced neutropenia
- malignant melanoma
- myelodysplastic syndrome (MDS)
- neutropenia
- peripheral blood stem cell (PBSC) mobilization
- radiation exposure
- zidovudine-induced neutropenia
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- anorexia
- antibody formation
- anxiety
- arthralgia
- asthenia
- bleeding
- bone pain
- capillary leak syndrome
- chest pain (unspecified)
- chills
- diarrhea
- dysphagia
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- erythema
- fever
- flushing
- GI bleeding
- headache
- hematemesis
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hypertension
- hypoalbuminemia
- hypomagnesemia
- hypotension
- hypoxia
- infusion-related reactions
- injection site reaction
- insomnia
- leukocytosis
- leukopenia
- malaise
- myalgia
- nausea
- nephrotoxicity
- ocular hemorrhage
- pericardial effusion
- peripheral edema
- pharyngitis
- pleural effusion
- prolonged bleeding time
- pruritus
- rash
- sinus tachycardia
- supraventricular tachycardia (SVT)
- syncope
- thrombocytopenia
- thromboembolism
- urticaria
- vomiting
- weight gain
- weight loss
Monitoring Parameters
- CBC with differential
- platelet count
Contraindications
- benzyl alcohol hypersensitivity
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- chemotherapy
- edema
- heart failure
- infusion-related reactions
- leukemia
- leukocytosis
- neonates
- pericardial effusion
- pleural effusion
- pregnancy
- pulmonary disease
- radiation therapy
Interactions
- Azelastine; Fluticasone
- Beclomethasone
- Betamethasone
- Budesonide
- Budesonide; Formoterol
- Ciclesonide
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Deflazacort
- Dexamethasone
- Fludrocortisone
- Flunisolide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Hydrocortisone
- Lithium
- Methylprednisolone
- Mometasone
- Prednisolone
- Prednisone
- Triamcinolone