What is Sarecycline
Sarecycline is a tetracycline-class antibiotic indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older.
The efficacy of sarecycline was established in 2 clinical trials in patients with acne. At 12 weeks, a significantly higher proportion of sarecycline-treated patients had improved acne and a reduction in inflammatory acne lesions compared with placebo.
As with other tetracyclines, sarecycline should not be used in pediatric patients younger than 8 years due to the potential for permanent tooth discoloration and decay if used during tooth development.
Brand Name
Seysara
Indications
- acne vulgaris
- Propionibacterium acnes
Side Effects
- blurred vision
- candidiasis
- diarrhea
- diplopia
- dizziness
- enamel hypoplasia
- enterocolitis
- erythema
- headache
- increased intracranial pressure
- infertility
- nausea
- onycholysis
- papilledema
- paresthesias
- photosensitivity
- pseudomembranous colitis
- pseudotumor cerebri
- rash
- spermatogenesis inhibition
- superinfection
- tooth discoloration
- vertigo
- visual impairment
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- activities requiring coordination and concentration
- breast-feeding
- children
- colitis
- diarrhea
- driving or operating machinery
- GI disease
- increased intracranial pressure
- infants
- infertility
- inflammatory bowel disease
- neonates
- papilledema
- pregnancy
- pseudomembranous colitis
- reproductive risk
- sunlight (UV) exposure
- tetracyclines hypersensitivity
- ulcerative colitis
Interactions
- Acitretin
- Afatinib
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Ampicillin
- Ampicillin; Sulbactam
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Betrixaban
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Carbenicillin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cholestyramine
- Chromium
- Colchicine
- Colchicine; Probenecid
- Colesevelam
- Colestipol
- Dicloxacillin
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Digoxin
- Doxorubicin
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Halobetasol; Tazarotene
- Heparin
- Hetastarch; Dextrose; Electrolytes
- Hydrochlorothiazide, HCTZ; Quinapril
- Insoluble Prussian Blue
- Iron
- Iron Salts
- Iron Sucrose, Sucroferric Oxyhydroxide
- Isotretinoin
- Lanthanum Carbonate
- Lapatinib
- Lefamulin
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Magnesium
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salts
- Methotrexate
- Methoxsalen
- Mipomersen
- Molindone
- Nafcillin
- Neuromuscular blockers
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oxacillin
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Penicillins
- Photosensitizing agents (topical)
- Piperacillin
- Piperacillin; Tazobactam
- Polycarbophil
- Polysaccharide-Iron Complex
- Porfimer
- Pyridostigmine
- Quinapril
- Rimegepant
- Sodium Bicarbonate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- St. John’s Wort, Hypericum perforatum
- Sucralfate
- Sulfonylureas
- Talazoparib
- Tazarotene
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Topotecan
- Tretinoin, ATRA
- Ubrogepant
- Venetoclax
- Verteporfin
- Warfarin
- Zinc
- Zinc Salts
