What's on this Page
What is Risedronate
Risedronate is a potent oral second-generation pyridinyl bisphosphonate; it differs structurally from other available bisphosphonates due to the pyridinyl side chain shielding the active amino group. Monthly, weekly, or daily regimens are available for selected conditions.
Treatment with risedronate is associated with significant increases in bone mineral density (BMD) and reduces the risk for radiographic vertebral and non-vertebral fractures (e.g., hip fractures) in postmenopausal women.
Brand Names
Actonel | Atelvia
Indications
- bone metastases
- osteoporosis
- osteoporosis prophylaxis
- Paget’s disease
Side Effects
- abdominal pain
- angioedema
- arrhythmia exacerbation
- arthralgia
- asthenia
- atrial fibrillation
- back pain
- bone fractures
- bone pain
- bullous rash
- cataracts
- chest pain (unspecified)
- conjunctivitis
- constipation
- depression
- diarrhea
- dizziness
- dyspepsia
- dysphagia
- esophageal ulceration
- esophagitis
- gastritis
- gastroesophageal reflux
- GI bleeding
- GI perforation
- glossitis
- headache
- hypertension
- hypocalcemia
- hypophosphatemia
- infection
- influenza
- insomnia
- iritis
- musculoskeletal pain
- myalgia
- nausea
- nephrolithiasis
- ocular inflammation
- ocular pain
- oral ulceration
- osteonecrosis
- peptic ulcer
- peripheral edema
- pharyngitis
- prostatic hypertrophy
- pyrosis (heartburn)
- rash
- rhinitis
- sinusitis
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- uveitis
- visual impairment
- vomiting
Monitoring Parameters
- serum 25(OH)hydroxyvitamin D concentrations
- serum alkaline phosphatase
- serum calcium
- serum creatinine/BUN
- serum phosphate
Contraindications
- achalasia
- anemia
- breast-feeding
- chemotherapy
- children
- coagulopathy
- corticosteroid therapy
- dental disease
- dental work
- dysphagia
- esophageal stricture
- esophagitis
- gastritis
- gastroesophageal reflux disease (GERD)
- geriatric
- GI disease
- hiatal hernia
- hyperparathyroidism
- hypocalcemia
- inability to stand or sit upright
- infection
- laboratory test interference
- phosphonate hypersensitivity
- pregnancy
- renal failure
- renal impairment
- vitamin D deficiency
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Celecoxib
- Chromium
- Cimetidine
- Deferasirox
- Dexlansoprazole
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Esomeprazole
- Esomeprazole; Naproxen
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Etodolac
- Famotidine
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- food
- H2-blockers
- Hetastarch; Dextrose; Electrolytes
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Iron
- Iron Salts
- Ketoprofen
- Ketorolac
- Lansoprazole
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Magnesium
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salts
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nizatidine
- Nonsteroidal antiinflammatory drugs
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oxaprozin
- Pantoprazole
- Piroxicam
- Polycarbophil
- Polysaccharide-Iron Complex
- Proton pump inhibitors
- Rabeprazole
- Ranitidine
- Rofecoxib
- Sodium Bicarbonate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sulindac
- Tolmetin
- Valdecoxib
- Vitamin A
