Sotalol

What is Sotalol

Sotalol is a hydrophilic, nonselective beta-adrenergic blocking agent, with low lipid-solubility. It is used to treat ventricular and supraventricular arrhythmias.

Indications & Dosage

  • atrial fibrillation
  • atrial fibrillation prophylaxis
  • atrial flutter
  • cardiac surgery
  • junctional ectopic tachycardia
  • paroxysmal atrial tachycardia
  • paroxysmal supraventricular tachycardia (PSVT)
  • supraventricular arrhythmias
  • ventricular tachycardia
  • Wolff-Parkinson-White (WPW) syndrome

Side Effects

  1. abdominal pain
  2. alopecia
  3. arrhythmia exacerbation
  4. asthenia
  5. AV block
  6. bradycardia
  7. bronchospasm
  8. chest pain (unspecified)
  9. confusion
  10. cough
  11. depression
  12. diabetes mellitus
  13. diarrhea
  14. dizziness
  15. dyspnea
  16. emotional lability
  17. eosinophilia
  18. fatigue
  19. fever
  20. headache
  21. heart failure
  22. hyperglycemia
  23. hyperhidrosis
  24. hyperlipidemia
  25. hypoglycemia
  26. hypotension
  27. leukopenia
  28. muscle paralysis
  29. musculoskeletal pain
  30. myalgia
  31. nausea
  32. palpitations
  33. peripheral neuropathy
  34. photosensitivity
  35. pruritus
  36. pulmonary edema
  37. QT prolongation
  38. thrombocytopenia
  39. torsade de pointes
  40. ventricular fibrillation
  41. ventricular tachycardia
  42. vertigo
  43. visual impairment
  44. vomiting
  45. weakness
  46. withdrawal

Monitoring Parameters

  • ECG
  • serum creatinine/BUN

Contraindications

  • abrupt discontinuation
  • acute bronchospasm
  • acute myocardial infarction
  • alcoholism
  • asthma
  • AV block
  • bradycardia
  • breast-feeding
  • bronchitis
  • cardiac arrhythmias
  • cardiac disease
  • cardiogenic shock
  • chronic lung disease (CLD)
  • coronary artery disease
  • diabetes mellitus
  • diarrhea
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • infertility
  • labor
  • laboratory test interference
  • long QT syndrome
  • malnutrition
  • myocardial infarction
  • obstetric delivery
  • peripheral vascular disease
  • pregnancy
  • QT prolongation
  • Raynaud’s phenomenon
  • renal failure
  • renal impairment
  • reproductive risk
  • requires a specialized care setting
  • requires an experienced clinician
  • sick sinus syndrome
  • surgery
  • thyroid disease
  • ventricular arrhythmias
  • ventricular fibrillation
  • ventricular tachycardia

Interactions

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