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What is Rifampin
Rifampin (rifampicin), a semisynthetic rifamycin antibiotic, is primarily used as part of first-line, combination therapy in the treatment of tuberculosis.
Rifampin is also used to treat asymptomatic carriers of Neisseria meningitidis; as prophylaxis against Haemophilus influenzae type b in high-risk contacts; and in the treatment of rare diseases such as Hansen’s disease (leprosy), bartonellosis, and brucellosis. Rifampin has been used in combination with vancomycin for synergy in staphylococcal infections; however, data are insufficient to support its routine use.
Indications
- bacteremia
- bacterial colonization eradication
- bartonellosis
- bone and joint infections
- brain abscess
- endocarditis
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus influenzae type b prophylaxis
- leprosy (Hansen’s disease)
- meningitis
- meningococcal infection prophylaxis
- Mycobacterium leprae
- Mycobacterium tuberculosis
- Neisseria meningitidis
- orthopedic device-related infection
- osteomyelitis
- pruritus
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- subdural empyema
- tuberculosis infection
- tuberculosis prophylaxis
- ventriculitis
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- ataxia
- bleeding
- bone pain
- bronchospasm
- chest pain (unspecified)
- chills
- cholestasis
- confusion
- conjunctivitis
- contact lens discoloration
- cough
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fatigue
- fever
- flatulence
- flushing
- headache
- hematuria
- hemolysis
- hemolytic anemia
- hepatic failure
- hepatitis
- hepatotoxicity
- hyperbilirubinemia
- hyperuricemia
- hypotension
- interstitial nephritis
- intracranial bleeding
- jaundice
- leukopenia
- lymphadenopathy
- menstrual irregularity
- myalgia
- myopathy
- nausea
- neutropenia
- palpitations
- pemphigus
- peripheral edema
- porphyria
- pruritus
- pseudomembranous colitis
- psychosis
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal tubular necrosis
- Stevens-Johnson syndrome
- superinfection
- syncope
- thrombocytopenia
- tooth discoloration
- toxic epidermal necrolysis
- urine discoloration
- urticaria
- vasculitis
- visual impairment
- vitamin B6 deficiency
- vitamin D deficiency
- vomiting
- weakness
- wheezing
Monitoring Parameters
- CBC
- INR
- LFTs
- platelet count
- prothrombin time (PT)
- serum creatinine
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- anticoagulant therapy
- antimicrobial resistance
- breast-feeding
- colitis
- contact lenses
- diabetes mellitus
- diarrhea
- extravasation
- geriatric
- GI disease
- hepatic disease
- human immunodeficiency virus (HIV) infection
- inflammatory bowel disease
- intramuscular administration
- malnutrition
- porphyria
- pregnancy
- pseudomembranous colitis
- rifamycin hypersensitivity
- subcutaneous administration
- ulcerative colitis
- vitamin K deficiency
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abemaciclib
- Abiraterone
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Afatinib
- Alendronate; Cholecalciferol
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Pioglitazone
- Alosetron
- Alpelisib
- Alprazolam
- Altretamine
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Antacids
- Apixaban
- Apremilast
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atovaquone
- Atovaquone; Proguanil
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- Avanafil
- Avapritinib
- Avatrombopag
- Axitinib
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Bedaquiline
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- Bendamustine
- Benzhydrocodone; Acetaminophen
- Bepridil
- Betrixaban
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- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
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- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Brivaracetam
- Bromocriptine
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- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
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- Buprenorphine
- Buprenorphine; Naloxone
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- Buspirone
- Cabozantinib
- Caffeine
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- Calcium Carbonate
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- Canagliflozin
- Canagliflozin; Metformin
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- Capreomycin
- Carbamazepine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Carvedilol
- Caspofungin
- Cefazolin
- Celecoxib
- Ceritinib
- Cevimeline
- Chloramphenicol
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpropamide
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clindamycin
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Copanlisib
- Crizotinib
- Cyclophosphamide
- Cyclosporine
- Dabigatran
- Daclatasvir
- Dapagliflozin
- Dapagliflozin; Metformin
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- Dapsone
- Darifenacin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
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- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deferasirox
- Deflazacort
- Delavirdine
- Desipramine
- Dexamethasone
- Dextromethorphan; Quinidine
- Diazepam
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- Diethylstilbestrol, DES
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Docetaxel
- Dolasetron
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxepin
- Doxercalciferol
- Doxorubicin
- Doxycycline
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Entacapone
- Entrectinib
- Enzalutamide
- Eravacycline
- Erdafitinib
- Ergocalciferol, Vitamin D2
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Estazolam
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Eszopiclone
- Ethambutol
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethionamide
- Ethotoin
- Etonogestrel
- Etravirine
- Everolimus
- Exemestane
- Ezetimibe; Simvastatin
- Fedratinib
- Felodipine
- Fentanyl
- Fesoterodine
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flibanserin
- Fluconazole
- Fluoxetine; Olanzapine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- food
- Fosamprenavir
- Fosphenytoin
- Fostamatinib
- Galantamine
- Gefitinib
- Gemfibrozil
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ixazomib
- Ketoconazole
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamotrigine
- Lapatinib
- Larotrectinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Leflunomide
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide; Norethindrone
- Levobupivacaine
- Levomethadyl
- Levonorgestrel
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lidocaine
- Linagliptin
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macimorelin
- Macitentan
- Magnesium Hydroxide
- Maraviroc
- Mebendazole
- Medroxyprogesterone
- Mefloquine
- Megestrol
- Melatonin
- Mestranol; Norethindrone
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Methadone
- Methylprednisolone
- Metoprolol
- Mexiletine
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Modafinil
- Montelukast
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Mycophenolate
- Naldemedine
- Naloxegol
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Norethindrone
- Norfloxacin
- Nortriptyline
- Olanzapine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Osilodrostat
- Osimertinib
- Ospemifene
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Ozanimod
- Paclitaxel
- Palbociclib
- Paliperidone
- Paricalcitol
- Pazopanib
- Pemigatinib
- Pentobarbital
- Perampanel
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phenothiazines
- Phenytoin
- Pimavanserin
- Pioglitazone
- Pitavastatin
- Pitolisant
- Polatuzumab Vedotin
- Pomalidomide
- Ponatinib
- Posaconazole
- Pravastatin
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- Prednisolone
- Prednisone
- Primidone
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- Propafenone
- Propranolol
- Proton pump inhibitors
- Protriptyline
- Pyrazinamide, PZA
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- Quinidine
- Quinine
- Raltegravir
- Ramelteon
- Ranolazine
- Red Yeast Rice
- Regorafenib
- Remdesivir
- Repaglinide
- Revefenacin
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Riluzole
- Rimegepant
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- Ripretinib
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
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- Romidepsin
- Ropinirole
- Rosiglitazone
- Ruxolitinib
- Sacubitril; Valsartan
- Sapropterin
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selexipag
- Selpercatinib
- Selumetinib
- Sertraline
- Sevoflurane
- Sildenafil
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sodium Bicarbonate
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sonidegib
- Sorafenib
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfonylureas
- Sunitinib
- Suvorexant
- Tacrolimus
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- Telaprevir
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- Terbinafine
- Teriflunomide
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Thiotepa
- Thiothixene
- Thyroid hormones
- Ticagrelor
- Tinidazole
- Tipranavir
- Tocainide
- Tofacitinib
- Tolazamide
- Tolbutamide
- Tolvaptan
- Toremifene
- Torsemide
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
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- Treprostinil
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- Triamcinolone
- Triazolam
- Tricyclic antidepressants
- Trimethoprim
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- Trimipramine
- Tucatinib
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- Upadacitinib
- Valbenazine
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- Valsartan
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- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Vortioxetine
- Voxelotor
- Warfarin
- Zaleplon
- Zanubrutinib
- Zidovudine, ZDV
- Ziprasidone
- Zolpidem
- Zonisamide
