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What is Rifabutin
Rifabutin is an oral antimycobacterial agent. A derivative of rifamycin, rifabutin has been shown to be effective as a prophylactic agent against disseminated M. avium complex in patients with AIDS.
Rifabutin is recommended as an alternative to clarithromycin or azithromycin for primary Mycobacterium avium complex prophylaxis in HIV-infected patients.
Rifabutin is also considered an alternative to rifampin for tuberculosis and tuberculosis prophylaxis in HIV-infected patients when the organism is likely to be resistant to isoniazid.
Rifabutin was approved by the FDA as a priority drug in December 1992.
Brand Name
Mycobutin
Indications
- Helicobacter pylori (H. pylori) eradication
- Mycobacterium avium
- Mycobacterium avium complex (MAC) prophylaxis
- Mycobacterium avium complex infection
- Mycobacterium intracellulare
- Mycobacterium leprae
- Mycobacterium tuberculosis
- tuberculosis infection
- tuberculosis prophylaxis
Side Effects
- abdominal pain
- agranulocytosis
- anemia
- anorexia
- aphasia
- arthralgia
- asthenia
- bronchospasm
- chest pain (unspecified)
- chills
- confusion
- conjunctivitis
- contact lens discoloration
- cough
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- eosinophilia
- eructation
- fatigue
- fever
- flatulence
- headache
- hemolysis
- hepatitis
- hypotension
- insomnia
- jaundice
- leukopenia
- lymphopenia
- musculoskeletal pain
- myalgia
- nausea
- neutropenia
- ocular pain
- palpitations
- pancytopenia
- paresthesias
- pseudomembranous colitis
- rash
- seizures
- skin discoloration
- ST-T wave changes
- superinfection
- syncope
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- urine discoloration
- urticaria
- uveitis
- visual impairment
- vomiting
- weakness
Monitoring Parameters
- CBC
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- breast-feeding
- children
- colitis
- contact lenses
- diarrhea
- geriatric
- GI disease
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- inflammatory bowel disease
- laboratory test interference
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- rifamycin hypersensitivity
- ulcerative colitis
- viral infection
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abemaciclib
- Abiraterone
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alosetron
- Alprazolam
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atovaquone
- Atovaquone; Proguanil
- Avanafil
- Avapritinib
- Axitinib
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Bedaquiline
- Benzhydrocodone; Acetaminophen
- Bepridil
- Bicalutamide
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Cabozantinib
- Capmatinib
- Capreomycin
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carvedilol
- Caspofungin
- Ceritinib
- Cerivastatin
- Cevimeline
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpropamide
- Cinacalcet
- Cisapride
- Citalopram
- Clarithromycin
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Cyclophosphamide
- Cyclosporine
- Daclatasvir
- Dapsone
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Dexamethasone
- Dextromethorphan; Quinidine
- Diazepam
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Enalapril; Felodipine
- Encorafenib
- Entrectinib
- Enzalutamide
- Erdafitinib
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Estazolam
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Eszopiclone
- Ethambutol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethionamide
- Ethotoin
- Etonogestrel
- Etravirine
- Ezetimibe; Simvastatin
- Fedratinib
- Felodipine
- Fentanyl
- Flibanserin
- Fluconazole
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- food
- Fosamprenavir
- Fosphenytoin
- Galantamine
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivabradine
- Ivacaftor
- Ixabepilone
- Ixazomib
- Ketoconazole
- Lamivudine, 3TC; Zidovudine, ZDV
- Lapatinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide; Norethindrone
- Levobupivacaine
- Levomethadyl
- Levonorgestrel
- Lidocaine
- Linagliptin
- Linagliptin; Metformin
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Maraviroc
- Mebendazole
- Medroxyprogesterone
- Mefloquine
- Megestrol
- Mestranol; Norethindrone
- Metformin; Repaglinide
- Methadone
- Methylprednisolone
- Metoprolol
- Mexiletine
- Midazolam
- Mifepristone
- Mitotane
- Modafinil
- Montelukast
- Nelfinavir
- Neratinib
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Norethindrone
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Oritavancin
- Oxybutynin
- Oxycodone
- Paclitaxel
- Panobinostat
- Paricalcitol
- Pazopanib
- Pemigatinib
- Perampanel
- Perindopril; Amlodipine
- Phenothiazines
- Phenytoin
- Pimavanserin
- Posaconazole
- Pravastatin
- Praziquantel
- Prednisolone
- Prednisone
- Progesterone
- Propafenone
- Propranolol
- Proton pump inhibitors
- Pyrazinamide, PZA
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Red Yeast Rice
- Remdesivir
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Rimegepant
- Ritonavir
- Rivaroxaban
- Roflumilast
- Romidepsin
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sertraline
- Sildenafil
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sonidegib
- Sorafenib
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Sunitinib
- Tacrolimus
- Tasimelteon
- Tazemetostat
- Telaprevir
- Telotristat Ethyl
- Temsirolimus
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Terbinafine
- Tezacaftor; Ivacaftor
- Thiothixene
- Tinidazole
- Tipranavir
- Tolazamide
- Tolbutamide
- Tolvaptan
- Toremifene
- Trandolapril; Verapamil
- Tretinoin, ATRA
- Triamcinolone
- Triazolam
- Trimethoprim
- Trimetrexate
- Tucatinib
- Ubrogepant
- Ulipristal
- Vemurafenib
- Venetoclax
- Verapamil
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Voxelotor
- Warfarin
- Zanubrutinib
- Zidovudine, ZDV
- Ziprasidone
- Zolpidem
- Zonisamide