Ulipristal

What is Ulipristal

Ulipristal is a progesterone agonist/antagonist emergency contraceptive. It is indicated to prevent pregnancy after unprotected intercourse or a known or suspected contraceptive failure for up to 5 days after intercourse and is available only by prescription in the U.S. 

Brand Name

Ella

Indications

  • postcoital contraception
  • uterine leiomyomata

Monitoring Parameters

  • pregnancy testing

Contraindications

  • acquired immunodeficiency syndrome (AIDS)
  • breast-feeding
  • children
  • contraception requirements
  • ectopic pregnancy
  • hepatic disease
  • human immunodeficiency virus (HIV) infection
  • menstrual irregularity
  • pregnancy
  • sexually transmitted disease

Drug Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Aldesleukin, IL-2
  • Amiodarone
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Apalutamide
  • Armodafinil
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bexarotene
  • Boceprevir
  • Bosentan
  • Butabarbital
  • Carbamazepine
  • Cenobamate
  • Ceritinib
  • Chloramphenicol
  • Cimetidine
  • Clarithromycin
  • Clobazam
  • Cobicistat
  • Cobimetinib
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Cyclosporine
  • Dabigatran
  • Dabrafenib
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Delavirdine
  • Dexamethasone
  • Dextromethorphan; Quinidine
  • Digoxin
  • Diltiazem
  • Dronedarone
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enzalutamide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Etravirine
  • Felbamate
  • Fexofenadine
  • Fexofenadine; Pseudoephedrine
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flutamide
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • grapefruit juice
  • Griseofulvin
  • Idelalisib
  • Imatinib
  • Indinavir
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Mefloquine
  • Mephobarbital
  • Methohexital
  • Mitotane
  • Modafinil
  • Nefazodone
  • Nelfinavir
  • Nevirapine
  • Nicardipine
  • Octreotide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Oxcarbazepine
  • Pentobarbital
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
  • Posaconazole
  • Primidone
  • Progestins
  • Quinidine
  • Quinine
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Rivaroxaban
  • Saquinavir
  • Secobarbital
  • St. John’s Wort, Hypericum perforatum
  • Telithromycin
  • Telotristat Ethyl
  • Thiopental
  • Tipranavir
  • Topiramate
  • Topotecan
  • Trandolapril; Verapamil
  • Tucatinib
  • Verapamil
  • Voriconazole
  • Zafirlukast

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. breakthrough bleeding
  4. dizziness
  5. dysmenorrhea
  6. fatigue
  7. headache
  8. menstrual irregularity
  9. nausea
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