Sonidegib

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What is Sonidegib

Sonidegib (LDE225) is an oral inhibitor of smoothened (SMO), a transmembrane protein involved in Hedgehog (Hh) signal transduction, which is important in normal embryogenic growth and development, and becomes less active in adults.

SMO is normally inhibited by another transmembrane protein, patched (PTCH1). Abnormal Hh signaling plays an important role in basal cell carcinoma.

Brand Name

ODOMZO

Indications & Dosage

  • basal cell carcinoma

Side Effects

  1. abdominal pain
  2. alopecia
  3. anemia
  4. anorexia
  5. anorexia
  6. diarrhea
  7. diarrhea
  8. dysgeusia
  9. elevated hepatic enzymes
  10. elevated hepatic enzymes
  11. fatigue
  12. fatigue
  13. fetal death
  14. growth inhibition
  15. headache
  16. headache
  17. hyperamylasemia
  18. hyperamylasemia
  19. hyperglycemia
  20. hyperglycemia
  21. lymphopenia
  22. lymphopenia
  23. muscle cramps
  24. muscle cramps
  25. musculoskeletal pain
  26. musculoskeletal pain
  27. myalgia
  28. nausea
  29. nausea
  30. pruritus
  31. teratogenesis
  32. vomiting
  33. vomiting
  34. weight loss
  35. weight loss

Monitoring Parameters

  • creatine phosphokinase (CPK)
  • pregnancy testing
  • serum creatinine/BUN

Contraindications

  • blood donation
  • breast-feeding
  • children
  • contraception requirements
  • geriatric
  • growth inhibition
  • infants
  • infertility
  • intrauterine fetal death
  • male-mediated teratogenicity
  • neonates
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • rhabdomyolysis

Interactions

  • Amiodarone
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Armodafinil
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bexarotene
  • Boceprevir
  • Bosentan
  • Carbamazepine
  • Cenobamate
  • Ceritinib
  • Chloramphenicol
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Delavirdine
  • Dexamethasone
  • Diltiazem
  • Dronedarone
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enzalutamide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Etravirine
  • Famotidine
  • Famotidine; Ibuprofen
  • Fedratinib
  • Fluconazole
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • grapefruit juice
  • Idelalisib
  • Imatinib
  • Indinavir
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Lefamulin
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Lopinavir; Ritonavir
  • Lorlatinib
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Mifepristone
  • Mitotane
  • Modafinil
  • Nafcillin
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Nicardipine
  • Nilotinib
  • Nizatidine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Oritavancin
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Quinine
  • Ranitidine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Ritonavir
  • Saquinavir
  • St. John’s Wort, Hypericum perforatum
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Tipranavir
  • Trandolapril; Verapamil
  • Tucatinib
  • Verapamil
  • Voriconazole

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