What is Sonidegib
Sonidegib (LDE225) is an oral inhibitor of smoothened (SMO), a transmembrane protein involved in Hedgehog (Hh) signal transduction, which is important in normal embryogenic growth and development, and becomes less active in adults.
SMO is normally inhibited by another transmembrane protein, patched (PTCH1). Abnormal Hh signaling plays an important role in basal cell carcinoma.
Brand Name
ODOMZO
Indications & Dosage
- basal cell carcinoma
Side Effects
- abdominal pain
- alopecia
- anemia
- anorexia
- anorexia
- diarrhea
- diarrhea
- dysgeusia
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fetal death
- growth inhibition
- headache
- headache
- hyperamylasemia
- hyperamylasemia
- hyperglycemia
- hyperglycemia
- lymphopenia
- lymphopenia
- muscle cramps
- muscle cramps
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- nausea
- nausea
- pruritus
- teratogenesis
- vomiting
- vomiting
- weight loss
- weight loss
Monitoring Parameters
- creatine phosphokinase (CPK)
- pregnancy testing
- serum creatinine/BUN
Contraindications
- blood donation
- breast-feeding
- children
- contraception requirements
- geriatric
- growth inhibition
- infants
- infertility
- intrauterine fetal death
- male-mediated teratogenicity
- neonates
- pregnancy
- pregnancy testing
- reproductive risk
- rhabdomyolysis
Interactions
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Boceprevir
- Bosentan
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Dexamethasone
- Diltiazem
- Dronedarone
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Etravirine
- Famotidine
- Famotidine; Ibuprofen
- Fedratinib
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nilotinib
- Nizatidine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Quinine
- Ranitidine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritonavir
- Saquinavir
- St. John’s Wort, Hypericum perforatum
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Verapamil
- Voriconazole
