Solriamfetol

What is Solriamfetol

Solriamfetol is a dopamine and norepinephrine reuptake inhibitor approved to improve wakefulness in adults with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea.

In patients with obstructive sleep apnea, the underlying airway obstruction should be treated (e.g., with CPAP) for at least 1 month prior to initiating solriamfetol.

Increases in blood pressure, heart rate, and the development or worsening of psychiatric symptoms such as anxiety, insomnia, and irritability are possible during solriamfetol use. Blood pressure and heart rate should be assessed before initiating treatment with solriamfetol and throughout treatment with the drug.

Brand Name

SUNOSI

Indications & Dosage

  • narcolepsy
  • obstructive sleep apnea

Side Effects

  1. abdominal pain
  2. agitation
  3. anxiety
  4. chest pain (unspecified)
  5. constipation
  6. cough
  7. diarrhea
  8. dizziness
  9. dyspnea
  10. headache
  11. hyperhidrosis
  12. hypertension
  13. insomnia
  14. irritability
  15. nausea
  16. palpitations
  17. restlessness
  18. teeth grinding (bruxism)
  19. tremor
  20. vomiting
  21. weight loss
  22. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate

Contraindications

  • acute myocardial infarction
  • alcoholism
  • angina
  • bipolar disorder
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cerebrovascular disease
  • diabetes mellitus
  • dialysis
  • geriatric
  • heart failure
  • hyperlipidemia
  • hypertension
  • mania
  • MAOI therapy
  • myocardial infarction
  • obesity
  • pregnancy
  • psychosis
  • renal failure
  • renal impairment
  • schizophrenia
  • stroke
  • substance abuse
  • valvular heart disease
  • ventricular dysfunction

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Amantadine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Apomorphine
  • Armodafinil
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Benzphetamine
  • Bevacizumab
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine
  • Caffeine; Ergotamine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Desloratadine; Pseudoephedrine
  • Desvenlafaxine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dopamine
  • Droxidopa
  • Duloxetine
  • Entacapone
  • Ephedrine
  • Esketamine
  • Fexofenadine; Pseudoephedrine
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen; Pseudoephedrine
  • Isocarboxazid
  • Levodopa
  • Levomilnacipran
  • Lisdexamfetamine
  • Loratadine; Pseudoephedrine
  • Methamphetamine
  • Methylphenidate
  • Midodrine
  • Milnacipran
  • Modafinil
  • Monoamine oxidase inhibitors
  • Naproxen; Pseudoephedrine
  • Norepinephrine
  • Phenelzine
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pramipexole
  • Pseudoephedrine
  • Rasagiline
  • Ropinirole
  • Rotigotine
  • Safinamide
  • Selegiline
  • Serotonin norepinephrine reuptake inhibitors
  • Tolcapone
  • Tranylcypromine
  • Vasopressors
  • Venlafaxine
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