Hydroxyzine Brand Names
ANX | Atarax | Hyzine | Rezine | Vistaril
What is Hydroxyzine
Hydroxyzine is a piperazine class sedating antihistamine (H1-blocker) that is structurally related to buclizine, cyclizine, and meclizine. Hydroxyzine is effective in treating histamine-mediated pruritus or pruritus due to atopy or other allergic conditions.
The drug is considered an effective alternative treatment for anxiety disorders (e.g., generalized anxiety).
Hydroxyzine has been used for many years as a perioperative sedative and anxiolytic and is used to alleviate nausea and control emesis perioperatively.
Although many clinicians believe that hydroxyzine is one of the most sedating H1-blockers, a small study showed that hydroxyzine produced less sedation than either azatadine or clemastine.
The active metabolite of hydroxyzine is cetirizine, which is considered to be a low-sedating antihistamine.
Hydroxyzine has been available as a prescription drug since 1956.
Indications
- allergic rhinitis
- anxiety
- atopic dermatitis
- chronic idiopathic urticaria
- insomnia
- nausea/vomiting
- post-operative nausea/vomiting (PONV)
- post-operative nausea/vomiting (PONV) prophylaxis
- procedural sedation
- pruritus
- seasonal allergies
- urticaria
For the short-term treatment of anxiety, tension, and psychomotor agitation in conditions of emotional stress
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- appetite stimulation
- asthenia
- ataxia
- blurred vision
- confusion
- constipation
- contact dermatitis
- dizziness
- drowsiness
- dysarthria
- dyskinesia
- dystonic reaction
- fatigue
- hallucinations
- headache
- hemolysis
- hypotension
- impaired cognition
- injection site reaction
- insomnia
- maculopapular rash
- mydriasis
- palpitations
- priapism
- pruritus
- psychosis
- QT prolongation
- rash
- respiratory depression
- restlessness
- seizures
- sinus tachycardia
- tardive dyskinesia
- thrombosis
- tissue necrosis
- torsade de pointes
- tremor
- urinary retention
- urticaria
- weakness
- xerophthalmia
- xerostomia
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- anticholinergic medications
- apheresis
- asthma
- AV block
- biliary cirrhosis
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- coadministration with other CNS depressants
- contact lenses
- dialysis
- driving or operating machinery
- electrolyte imbalance
- ethanol ingestion
- ethanol intoxication
- females
- fever
- geriatric
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hydroxyzine hypersensitivity
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- ileus
- infants
- intravenous administration
- labor
- long QT syndrome
- myocardial infarction
- neonates
- pheochromocytoma
- pregnancy
- premature neonates
- prostatic hypertrophy
- QT prolongation
- renal failure
- renal impairment
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- subcutaneous administration
- systemic lupus erythematosus (SLE)
- tissue necrosis
- torsade de pointes
- urinary retention
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Alosetron
- Amantadine
- Ambenonium Chloride
- Amiodarone
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anagrelide
- Anticholinergics
- Apomorphine
- Apraclonidine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atomoxetine
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Azithromycin
- Baclofen
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzphetamine
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlorcyclizine
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Crizotinib
- Cyclobenzaprine
- Dantrolene
- Daratumumab; Hyaluronidase
- Dasatinib
- Degarelix
- Desloratadine
- Desloratadine; Pseudoephedrine
- Deutetrabenazine
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dronabinol
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Entacapone
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Eszopiclone
- Ethanol
- Etomidate
- Ezogabine
- Fenfluramine
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fospropofol
- Gabapentin
- Galantamine
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Haloperidol
- Heparin
- Histrelin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Ibuprofen; Oxycodone
- Ibutilide
- Iloperidone
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Isocarboxazid
- Itraconazole
- Ivosidenib
- Ketamine
- Ketoconazole
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levocetirizine
- Levofloxacin
- Levomethadyl
- Levorphanol
- Lithium
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine
- Loratadine; Pseudoephedrine
- Loxapine
- Lumateperone
- Lurasidone
- Macimorelin
- Magnesium Salts
- Maprotiline
- Meclizine
- Mefloquine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Metaproterenol
- Metaxalone
- Methadone
- Methamphetamine
- Methocarbamol
- Methohexital
- Metoclopramide
- Metronidazole
- Metyrapone
- Metyrosine
- Midostaurin
- Mifepristone
- Minocycline
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nabilone
- Nalbuphine
- Nefazodone
- Nilotinib
- Norfloxacin
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ondansetron
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Panobinostat
- Papaverine
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitolisant
- Posaconazole
- Pramipexole
- Pregabalin
- Primaquine
- Primidone
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propofol
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Rituximab; Hyaluronidase
- Rivastigmine
- Romidepsin
- Ropinirole
- Rotigotine
- Safinamide
- Salmeterol
- Saquinavir
- Secobarbital
- Selegiline
- Selpercatinib
- Sertraline
- Short-acting beta-agonists
- Sincalide
- Siponimod
- Sodium Iodide
- Sodium Oxybate
- Solifenacin
- Sorafenib
- Sotalol
- Sufentanil
- Sunitinib
- Suvorexant
- Tacrine
- Tacrolimus
- Tamoxifen
- Tapentadol
- Tasimelteon
- Telavancin
- Telithromycin
- Terbutaline
- Tetrabenazine
- Thalidomide
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Tiotropium; Olodaterol
- Tizanidine
- Tolcapone
- Tolterodine
- Topiramate
- Toremifene
- Tramadol
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Triptorelin
- Trospium
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vigabatrin
- Vilazodone
- Voriconazole
- Vorinostat
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
