Hylan G F 20

Hylan G F 20 Brand Names- Synvisc | Synvisc-One

What is Hylan G F 20

Hylan G-F 20 products are classified by the FDA as medical devices, rather than drug products.

A medical device is a product intended to affect the structure or function of the body, but which does not achieve its primary purposes through the chemical action of a drug — nor is it dependent on being metabolized. These products relieve pain via viscosity and lubrication.

Hylan G-F 20 (Synvisc and Synvisc-One) is used as an intra-articular treatment for the pain of osteoarthritis. Hylan G-F 20 is an elastoviscous fluid containing cross-linked polymers of hyaluronan (hyaluronic acid) known as hylans. Hylan G-F 20 is produced from chicken combs and is used clinically as a viscoelastic agent.

Synvisc is administered as 3 injections, but a single injection option (same material and total treatment volume as Synvisc) is provided by Synvisc-One. Synvisc was approved by the FDA in August 1997 and Synvisc-One was approved in February 2009.


  • osteoarthritis

For the treatment of pain in osteoarthritis of the knee when response to conservative nonpharmacologic therapy and simple analgesics (e.g., acetaminophen) has been inadequate

Side Effects

  1. angioedema
  2. arthralgia
  3. arthropathy
  4. back pain
  5. chills
  6. dizziness
  7. dyspnea
  8. fever
  9. flushing
  10. headache
  11. hematoma
  12. hemorrhoids
  13. infection
  14. influenza
  15. injection site reaction
  16. malaise
  17. muscle cramps
  18. musculoskeletal pain
  19. nausea
  20. paresthesias
  21. peripheral edema
  22. pharyngitis
  23. phlebitis
  24. pruritus
  25. rash
  26. thrombocytopenia

Monitoring Parameters

  • laboratory monitoring not necessary


  • breast-feeding
  • children
  • egg hypersensitivity
  • hyaluronan (sodium hyaluronate) hypersensitivity
  • infants
  • infection
  • inflammation
  • intraarterial administration
  • intravenous administration
  • neonates
  • pregnancy
  • skin disease


  • Benzalkonium Chloride
  • Intra-articular Corticosteroids

Benzalkonium Chloride: (Major) Do not use concomitant disinfectants that contain quaternary ammonium salts (e.g., benzalkonium chloride) for skin preparation prior to hylan G-F 20 intra-articular injection, as hyaluronan can precipitate in the presence of these disinfectants. 

Intra-articular Corticosteroids: (Major) The safety and efficacy of hylan G-F 20 given concomitantly with other intra-articular injectables have not been established. Other intra-articular injections may include intra-articular steroids (betamethasone, dexamethasone, hydrocortisone, prednisolone, methylprednisolone, and triamcinolone). 


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