Hydrocortisone Neomycin Polymyxin B

Hydrocortisone Neomycin Polymyxin B Brand Names

AK-Spore HC Ophthalmic | AK-Spore HC Otic | Antibiotic Otic | Aural | Cortisporin | Cortomycin | Duomycin-HC | Oticin HC | Otimar | Oti-Sone | Otocidin | Pediotic | Uad

What is Hydrocortisone Neomycin Polymyxin B

Hydrocortisone Neomycin Polymyxin B are used together in otic and ophthalmic preparations to treat otitis externa or ocular inflammation.

Topical products are also available for treating corticosteroid-responsive dermatoses with secondary infection.

The acidity of the cream helps to restore the acidic pH of the skin. Hydrocortisone is a corticosteroid that exhibits both mineralocorticoid and glucocorticoid activity; it is used in these preparations for its antiinflammatory properties.

Neomycin is a aminoglycoside antibiotic derived from cultures of Streptomyces fradiae.

Polymyxin B is a polypeptide antibiotic derived from a strain of Bacillus polymyxa. Both of these antibiotics affect primarily gram-negative, aerobic bacteria, but are also effective against Staphylococcus aureus (methicillin-sensitive).

The FDA approved hydrocortisone neomycin polymyxin B ophthalmic and otic preparations prior to 1982.

The FDA first approved hydrocortisone, neomycin, and polymyxin B topical products in 1985.

Indications

  1. bacterial conjunctivitis
  2. dermatitis
  3. Enterobacter sp.
  4. Escherichia coli
  5. Haemophilus influenzae (beta-lactamase negative)
  6. Haemophilus influenzae (beta-lactamase positive)
  7. Klebsiella sp.
  8. Neisseria sp.
  9. ophthalmic infection
  10. otitis externa
  11. Pseudomonas aeruginosa
  12. Staphylococcus aureus (MSSA)
  13. uveitis

Side Effects

  1. anaphylactoid reactions
  2. blurred vision
  3. cataracts
  4. conjunctival hyperemia
  5. conjunctivitis
  6. contact dermatitis
  7. corneal erosion
  8. erythema
  9. folliculitis
  10. hearing loss
  11. keratitis
  12. miliaria
  13. ocular hypertension
  14. ocular irritation
  15. ocular pruritus
  16. pruritus
  17. rash
  18. renal failure (unspecified)
  19. skin atrophy
  20. skin hypopigmentation
  21. skin irritation
  22. striae
  23. superinfection
  24. xerosis

Monitoring Parameters

  • intraocular pressure

Contraindications

  • aminoglycoside hypersensitivity
  • asthma
  • breast-feeding
  • colitis
  • contact lenses
  • diarrhea
  • fungal infection
  • geriatric
  • GI disease
  • glaucoma
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • inflammatory bowel disease
  • neomycin hypersensitivity
  • occlusive dressing
  • ocular exposure
  • otitis media
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • sulfite hypersensitivity
  • surgery
  • tuberculosis
  • tympanic membrane perforation
  • ulcerative colitis
  • varicella
  • viral infection

Interactions

There are no drug interactions associated with Hydrocortisone; Neomycin; Polymyxin B products.

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