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Hydrocortisone Neomycin Polymyxin B Brand Names
AK-Spore HC Ophthalmic | AK-Spore HC Otic | Antibiotic Otic | Aural | Cortisporin | Cortomycin | Duomycin-HC | Oticin HC | Otimar | Oti-Sone | Otocidin | Pediotic | Uad
What is Hydrocortisone Neomycin Polymyxin B
Hydrocortisone Neomycin Polymyxin B are used together in otic and ophthalmic preparations to treat otitis externa or ocular inflammation.
Topical products are also available for treating corticosteroid-responsive dermatoses with secondary infection.
The acidity of the cream helps to restore the acidic pH of the skin. Hydrocortisone is a corticosteroid that exhibits both mineralocorticoid and glucocorticoid activity; it is used in these preparations for its antiinflammatory properties.
Neomycin is a aminoglycoside antibiotic derived from cultures of Streptomyces fradiae.
Polymyxin B is a polypeptide antibiotic derived from a strain of Bacillus polymyxa. Both of these antibiotics affect primarily gram-negative, aerobic bacteria, but are also effective against Staphylococcus aureus (methicillin-sensitive).
The FDA approved hydrocortisone neomycin polymyxin B ophthalmic and otic preparations prior to 1982.
The FDA first approved hydrocortisone, neomycin, and polymyxin B topical products in 1985.
Indications
- bacterial conjunctivitis
- dermatitis
- Enterobacter sp.
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella sp.
- Neisseria sp.
- ophthalmic infection
- otitis externa
- Pseudomonas aeruginosa
- Staphylococcus aureus (MSSA)
- uveitis
Side Effects
- anaphylactoid reactions
- blurred vision
- cataracts
- conjunctival hyperemia
- conjunctivitis
- contact dermatitis
- corneal erosion
- erythema
- folliculitis
- hearing loss
- keratitis
- miliaria
- ocular hypertension
- ocular irritation
- ocular pruritus
- pruritus
- rash
- renal failure (unspecified)
- skin atrophy
- skin hypopigmentation
- skin irritation
- striae
- superinfection
- xerosis
Monitoring Parameters
- intraocular pressure
Contraindications
- aminoglycoside hypersensitivity
- asthma
- breast-feeding
- colitis
- contact lenses
- diarrhea
- fungal infection
- geriatric
- GI disease
- glaucoma
- herpes infection
- hypothalamic-pituitary-adrenal (HPA) suppression
- inflammatory bowel disease
- neomycin hypersensitivity
- occlusive dressing
- ocular exposure
- otitis media
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- sulfite hypersensitivity
- surgery
- tuberculosis
- tympanic membrane perforation
- ulcerative colitis
- varicella
- viral infection
Interactions
There are no drug interactions associated with Hydrocortisone; Neomycin; Polymyxin B products.