Hydrocortisone Pramoxine

Hydrocortisone Pramoxine Brand Names

Analpram E | Analpram HC | EndaRoid | Enzone | Epifoam | HC Pram | Mezparox-HC | Mezparox-HC Forte | Novacort | Paramox-HC | PramCort | PRAM-HCA | Pramosone | Pramosone E | ProCort | Proctocream-HC | ProctoFoam HC | Zone A | Zone A Forte | Z-Pram

What is Hydrocortisone Pramoxine

Hydrocortisone and pramoxine are combined and used topically for the treatment of inflamed and pruritic skin.

Hydrocortisone is a glucocorticoid that has antiinflammatory, antipruritic, and vasoconstrictive properties; pramoxine is a topical anesthetic that provides relief of pain and itching.

Hydrocortisone pramoxine products are typically used for the relief of inflammation, pain and pruritus associated with perianal and rectal skin disorders, such as hemorrhoids, post-episiotomy healing, anal fissures, and other corticosteroid-responsive dermatoses.

Several different formulations are available, including topical cream, lotion and ointment and aerosol foams for topical or rectal use.

Indications

  1. anal fissures
  2. dermatitis
  3. hemorrhoids
  4. proctitis
  5. pruritus
  6. psoriasis
  7. skin inflammation
  8. ulcerative colitis

For the temporary relief of skin inflammation, pain, and pruritus associated with corticosteroid-responsive dermatitis, including psoriasis, anorectal inflammation, pain, pruritus, and swelling associated with hemorrhoids, proctitis, cryptitis, anal fissures, postoperative pain, and pruritus ani

Side Effects

  1. acneiform rash
  2. anaphylactoid reactions
  3. bleeding
  4. bronchospasm
  5. contact dermatitis
  6. Cushing’s syndrome
  7. edema
  8. erythema
  9. glycosuria
  10. hyperesthesia
  11. hyperglycemia
  12. hypertrichosis
  13. hypothalamic-pituitary-adrenal (HPA) suppression
  14. infection
  15. miliaria
  16. pruritus
  17. purpura
  18. skin atrophy
  19. skin hypopigmentation
  20. skin irritation
  21. striae
  22. urticaria
  23. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • cataracts
  • children
  • diabetes mellitus
  • fistula
  • fungal infection
  • geriatric
  • GI obstruction
  • GI perforation
  • glaucoma
  • hepatic disease
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • infants
  • infection
  • neonates
  • occlusive dressing
  • ocular exposure
  • ophthalmic administration
  • peripheral vascular disease
  • peritonitis
  • pregnancy
  • skin abrasion
  • skin atrophy
  • tuberculosis
  • ulcerative colitis
  • viral infection

Interactions

  • Adapalene; Benzoyl Peroxide
  • Benzocaine
  • Benzocaine; Butamben; Tetracaine
  • Benzoyl Peroxide
  • Benzoyl Peroxide; Clindamycin
  • Benzoyl Peroxide; Erythromycin
  • Benzoyl Peroxide; Sulfur
  • Dibucaine
  • Ethyl Chloride
  • Hydrocortisone; Lidocaine
  • Lidocaine
  • Lidocaine; Prilocaine
  • Lidocaine; Tetracaine
  • Tetracaine
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