Colistin Hydrocortisone Neomycin Thonzonium

Colistin Hydrocortisone Neomycin Thonzonium Brand Names

Coly-Mycin S | Cortisporin TC

What is Colistin Hydrocortisone Neomycin Thonzonium

Colistin sulfate hydrocortisone acetate neomycin sulfate thonzonium bromide is a combination antibacterial and antiinflammatory otic suspension indicated for the treatment of superficial bacterial infections of the external auditory canal and infections of mastoidectomy and fenestration cavities caused by susceptible organisms.

Colistin sulfate is a polypeptide antibiotic, which penetrates and disrupts the bacterial cell membrane, and neomycin is an aminoglycoside antibiotic, which inhibits bacterial protein synthesis.

Hydrocortisone acetate is a corticosteroid, which controls inflammation, edema, pruritus, and other dermal reactions.

Thonzonium bromide is a surface-active agent that promotes tissue contact by dispersion and penetration of the cellular debris and exudate.

Neomycin can induce permanent sensorineural hearing loss due to cochlear damage and risk is greater with prolonged use; therefore, limit use to 10 consecutive days.


  1. Escherichia coli
  2. Klebsiella pneumoniae
  3. otitis externa
  4. Pseudomonas aeruginosa
  5. Staphylococcus aureus (MSSA)

Side Effects

  1. contact dermatitis
  2. erythema
  3. folliculitis
  4. hearing loss
  5. hypertrichosis
  6. miliaria
  7. pruritus
  8. rash
  9. renal failure (unspecified)
  10. skin atrophy
  11. skin hypopigmentation
  12. skin irritation
  13. striae
  14. superinfection
  15. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary


  • aminoglycoside hypersensitivity
  • breast-feeding
  • colitis
  • diarrhea
  • hearing impairment
  • herpes infection
  • infants
  • neomycin hypersensitivity
  • neonates
  • ocular exposure
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • tympanic membrane perforation
  • varicella
  • viral infection


There are no drug interactions associated with Colistin Hydrocortisone Neomycin Thonzonium products.


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