Hydrocortisone Lidocaine

Hydrocortisone Lidocaine Brand Names

Ana-Lex HC | AnaMantle HC | AnaMantle-HC Forte | LidaMantle HC | LidaZone HC | LidoCort | Lidosol-HC | Peranex HC | RectaGel HC | Senatec HC

What is Hydrocortisone Lidocaine

Hydrocortisone and lidocaine are combined and used topically and rectally for the relief of inflammation, pain, and pruritus associated with minor skin irritations, hemorrhoids, and anal fissures.

Hydrocortisone is a corticosteroid that has antiinflammatory, antipruritic, and vasoconstrictive properties; lidocaine is a topical amide local anesthetic that provides relief of pain and itching.

Several different formulations are available, including creams, gels, and lotions; these combinations are for prescription use only.

Hydrocortisone and lidocaine were initially marketed for use before 1962, which is when Congress passed the amended Federal Food, Drug, and Cosmetic Act requiring that the FDA establish both safety and efficacy for all subsequently approved drugs.

Hydrocortisone lidocaine is an unapproved marketed drug that has not been formally evaluated by the FDA.

Indications

  1. anal fissures
  2. burns
  3. eczema
  4. hemorrhoids
  5. insect bites or stings
  6. mild pain
  7. pruritus
  8. skin abrasion

For the treatment of mild pain and pruritus due to pruritic eczema, skin abrasion, minor burns, insect bites or stings, and similar conditions of the skin and mucous membranes.

Side Effects

  1. acneiform rash
  2. adrenocortical insufficiency
  3. confusion
  4. contact dermatitis
  5. Cushing’s syndrome
  6. dizziness
  7. erythema
  8. folliculitis
  9. glycosuria
  10. growth inhibition
  11. hyperglycemia
  12. hypertrichosis
  13. hypotension
  14. hypothalamic-pituitary-adrenal (HPA) suppression
  15. increased intracranial pressure
  16. infection
  17. methemoglobinemia
  18. miliaria
  19. palpitations
  20. pruritus
  21. seizures
  22. skin atrophy
  23. skin hypopigmentation
  24. skin irritation
  25. striae
  26. tremor
  27. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • amide local anesthetic hypersensitivity
  • breast-feeding
  • cardiac disease
  • children
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • fungal infection
  • G6PD deficiency
  • geriatric
  • growth inhibition
  • hepatic disease
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • increased intracranial pressure
  • infants
  • infection
  • methemoglobinemia
  • neonates
  • occlusive dressing
  • ocular exposure
  • pregnancy
  • pulmonary disease
  • skin abrasion
  • skin atrophy
  • tuberculosis
  • varicella
  • viral infection

Interactions

  • Adapalene; Benzoyl Peroxide
  • Benzoyl Peroxide
  • Benzoyl Peroxide; Clindamycin
  • Benzoyl Peroxide; Erythromycin
  • Benzoyl Peroxide; Sulfur
  • Chloroxylenol; Hydrocortisone; Pramoxine
  • Dibucaine
  • Ethyl Chloride
  • Hydrocortisone; Pramoxine
  • Pramoxine
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