Bacitracin Hydrocortisone Neomycin Polymyxin B

Bacitracin Hydrocortisone Neomycin Polymyxin B Brand Names

AK-Spore HC Ophthalmic | Cortisporin | Cortomycin | Neo-Polycin HC | Neotricin HC | Ocu-Cort

What is Bacitracin Hydrocortisone Neomycin Polymyxin B

Bacitracin Hydrocortisone Neomycin Polymyxin B are used together in ophthalmic preparations or in a topical ointment to treat corticosteroid-responsive dermatoses with secondary infection.

Hydrocortisone is a corticosteroid that exhibits both mineralocorticoid and glucocorticoid activity; it is used in these preparations for its antiinflammatory properties.

Bacitracin is a mixture of cyclic polypeptides produced by Bacillus subtilis. Neomycin is a aminoglycoside antibiotic derived from cultures of Streptomyces fradiae.

Polymyxin B is a polypeptide antibiotic derived from a strain of Bacillus polymyxa.

Neomycin and polymyxin B affect primarily gram-negative, aerobic bacteria, while bacitracin is effective against gram-positive organisms. The FDA approved bacitracin, hydrocortisone, neomycin, and polymyxin B ophthalmic and topical preparations prior to 1982.

Indications

  1. bacterial conjunctivitis
  2. dermatitis
  3. Enterobacter sp.
  4. Escherichia coli
  5. Haemophilus influenzae (beta-lactamase negative)
  6. Haemophilus influenzae (beta-lactamase positive)
  7. Klebsiella sp.
  8. Neisseria sp.
  9. ophthalmic infection
  10. Pseudomonas aeruginosa
  11. Staphylococcus aureus (MSSA)
  12. Streptococcus pneumoniae
  13. Streptococcus sp.
  14. uveitis

Side Effects

  1. acneiform rash
  2. cataracts
  3. contact dermatitis
  4. erythema
  5. folliculitis
  6. hearing loss
  7. hypertrichosis
  8. impaired wound healing
  9. miliaria
  10. ocular hypertension
  11. ocular irritation
  12. ocular pruritus
  13. pruritus
  14. rash
  15. skin atrophy
  16. skin hypopigmentation
  17. skin irritation
  18. striae
  19. superinfection
  20. xerosis

Monitoring Parameters

  • intraocular pressure

Contraindications

  • aminoglycoside hypersensitivity
  • breast-feeding
  • cataracts
  • children
  • contact lenses
  • corticosteroid hypersensitivity
  • diarrhea
  • fungal infection
  • geriatric
  • glaucoma
  • hearing impairment
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • infants
  • neomycin hypersensitivity
  • neonates
  • occlusive dressing
  • ocular exposure
  • ocular surgery
  • polymyxin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • tuberculosis
  • tympanic membrane perforation
  • varicella
  • viral infection

Interactions

  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Bumetanide
  • Ethacrynic Acid
  • Furosemide
  • Loop diuretics
  • Torsemide
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