Gramicidin Neomycin Polymyxin B Brand Names
AK-Spore Ophthalmic | Neocidin | Neosporin | Ocu-Spore-G | Polymycin
What is Gramicidin Neomycin Polymyxin B
Gramicidin Neomycin Polymyxin B are antimicrobial agents used together in ophthalmic preparations to treat ocular bacterial infections.
The combination may also be used as prophylaxis when there is a risk of infection.
Gramicidin is a mixture of three pairs of antimicrobials (gramicidin A, B, and C) and is produced by growth of a strain of Bacillus brevis. Neomycin is a aminoglycoside antibiotic derived from cultures of Streptomyces fradiae. Polymyxin B is a polypeptide antibiotic derived from a strain of Bacillus polymyxa.
Gramicidin is active against a variety of gram-positive organisms; polymyxin B against a variety of gram-negative organisms; and neomycin against many gram-positive and gram-negative organisms.
Combining these antimicrobials provides an overlapping coverage against a wide range of gram-positive and gram-negative bacteria, including streptococci.
The FDA approved Gramicidin Neomycin Polymyxin B ophthalmic solution in June 1968.
- bacterial conjunctivitis
- Enterobacter sp.
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella sp.
- Neisseria sp.
- ophthalmic infection
- Pseudomonas aeruginosa
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Streptococcus pneumoniae
- Streptococcus sp.
- surgical infection prophylaxis
- anaphylactoid reactions
- blurred vision
- ocular irritation
- ocular pruritus
- laboratory monitoring not necessary
- aminoglycoside hypersensitivity
- contact lenses
- neomycin hypersensitivity
- polymyxin hypersensitivity
There are no drug interactions associated with Gramicidin; Neomycin; Polymyxin B products.