Cyclizine

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Cyclizine Brand Names- Cyclivert | Marezine

What is Cyclizine

Cyclizine is an oral, sedating H1 antagonist (antihistamine) with anticholinergic, antiemetic, and antivertigo properties.

Cyclizine is a piperazine derivative that is structurally related to buclizine, hydroxyzine, and meclizine. It is used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness.

Some data indicate that cyclizine may be misused alone or in combination with other drugs with abuse potential (e.g., opiates) to produce an hallucinogenic effect.

Cyclizine (Marezine) was approved by the FDA in 1953.

Indications

  • motion sickness

For over-the-counter (non-prescription) prevention and treatment of symptoms associated with motion sickness such as nausea, vomiting, and dizziness

Side Effects

  1. anorexia
  2. blurred vision
  3. constipation
  4. drowsiness
  5. dysuria
  6. euphoria
  7. excitability
  8. fatigue
  9. hallucinations
  10. hypotension
  11. nasal dryness
  12. palpitations
  13. restlessness
  14. sinus tachycardia
  15. urinary retention
  16. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • asthma
  • bladder obstruction
  • breast-feeding
  • bronchitis
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • driving or operating machinery
  • emphysema
  • ethanol intoxication
  • geriatric
  • GI obstruction
  • hepatic disease
  • ileus
  • infants
  • neonates
  • pregnancy
  • premature neonates
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • urinary retention

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Alosetron
  • Amantadine
  • Ambenonium Chloride
  • Amikacin
  • Aminoglycosides
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anticholinergics
  • Aripiprazole
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Belladonna; Opium
  • Benzodiazepines
  • Benzphetamine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorzoxazone
  • Clobazam
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Dantrolene
  • Daratumumab; Hyaluronidase
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dronabinol
  • Entacapone
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Fentanyl
  • Flibanserin
  • Fospropofol
  • Gabapentin
  • Galantamine
  • Gentamicin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Ipecac
  • Isocarboxazid
  • Kanamycin
  • Ketamine
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Lithium
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methocarbamol
  • Metoclopramide
  • Metyrapone
  • Metyrosine
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Opiate Agonists
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Paromomycin
  • Pentazocine
  • Pentazocine; Naloxone
  • Perampanel
  • Phenelzine
  • Pitolisant
  • Plazomicin
  • Pramipexole
  • Pregabalin
  • Procarbazine
  • Propofol
  • Propoxyphene
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Ropinirole
  • Safinamide
  • Selegiline
  • Sincalide
  • Sodium Iodide
  • Solifenacin
  • Streptomycin
  • Sufentanil
  • Suvorexant
  • Tacrine
  • Tasimelteon
  • Teniposide
  • Thalidomide
  • Thiothixene
  • Tizanidine
  • Tobramycin
  • Tolcapone
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Tricyclic antidepressants
  • Trimethobenzamide
  • Trospium
  • Vigabatrin
  • Vilazodone
  • Zaleplon
  • Ziconotide
  • Zolpidem

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