Cyanocobalamin Vitamin B12

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Cyanocobalamin Vitamin B12 Brand Names

B-12 Compliance Kit | B-12 Injection Kit | CaloMist | Cyomin | LA-12 | Nascobal | Nutri-Twelve | Physicians EZ Use B-12 | Primabalt

What is Cyanocobalamin Vitamin B12

Cyanocobalamin vitamin B12 is a B-vitamin. It is found in a variety of foods such as fish, shellfish, meats, and dairy products.

Although cyanocobalamin and vitamin B12 are terms used interchangeably, vitamin B12 is also available as hydroxocobalamin, a less commonly prescribed drug product.

Cyanocobalamin is available nasally, orally, and parenterally, and is equal in biologic activity to hydroxocobalamin.

Cyanocobalamin is used to treat pernicious anemia and prevent and treat vitamin B12 deficiency, as well as to determine vitamin B12 absorption in the Schilling test.

Vitamin B12 is an essential vitamin found in foods such as meat, eggs, and dairy products.

Deficiency in healthy individuals is rare; the elderly, strict vegetarians (i.e., vegan), and patients with malabsorption problems are more likely to become deficient. If vitamin B12 deficiency is not treated with a vitamin B12 supplement, then anemia, intestinal problems, and irreversible nerve damage may occur.

Oral therapy is not always effective, as some persons lack intrinsic factor, an endogenous substance produced by the stomach and necessary for oral B12 absorption.

Other patients may not be able to absorb oral vitamin B12 due to surgical removal or dysfunction of the intestines in the area where absorption of vitamin B12 occurs.

Thus, parenteral or nasal therapy may be needed; however, intranasal therapy should only be instituted for maintenance treatment after control of the condition has been obtained by the parenteral route.

Indications & Dosage

  1. macrocytic anemia
  2. methylmalonic aciduria
  3. nutritional supplementation
  4. pernicious anemia
  5. vitamin B12 deficiency
  6. vitamin B12 deficiency diagnosis
  7. vitamin B12 deficiency megaloblastic anemia

NOTE: Hematocrit, reticulocyte count, vitamin B12, folate, and iron concentrations should be obtained prior to treatment.

If folate concentrations are low in a patient with low B12 concentrations, folic acid should only be administered in combination with B12. Vitamin blood concentrations and peripheral blood counts should be monitored at one month of treatment and then at intervals of 3 to 6 months.

Side Effects

  1. aluminum toxicity
  2. anaphylactic shock
  3. anxiety
  4. asthenia
  5. back pain
  6. diarrhea
  7. dizziness
  8. dyspepsia
  9. dyspnea
  10. edema
  11. glossitis
  12. headache
  13. heart failure
  14. hypoesthesia
  15. hypokalemia
  16. infection
  17. myalgia
  18. nausea
  19. paresthesias
  20. polycythemia
  21. pruritus
  22. pulmonary edema
  23. rash
  24. thrombocytosis
  25. thrombosis
  26. vomiting

Monitoring Parameters

  • hemoglobin/hematocrit
  • MCV
  • platelet count
  • reticulocyte count
  • serum folate concentration
  • serum iron
  • serum potassium
  • serum vitamin B12 (cyanocobalamin) concentrations

Contraindications

  • anemia
  • benzyl alcohol hypersensitivity
  • bone marrow suppression
  • breast-feeding
  • folate deficiency
  • geriatric
  • hereditary optic nerve atrophy (Leber’s disease)
  • hypokalemia
  • infection
  • iron-deficiency anemia
  • neonates
  • polycythemia vera
  • pregnancy
  • renal failure
  • respiratory infection
  • rhinorrhea
  • uremia

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Omeprazole
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atracurium
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Betamethasone; Calcipotriene
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bisphosphonates
  • Calcipotriene
  • Calcitonin
  • Calcium Phosphate, Supersaturated
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Cardiac glycosides
  • Chloramphenicol
  • Chlorothiazide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Ciprofloxacin
  • Cisatracurium
  • Colchicine
  • Colchicine; Probenecid
  • Colesevelam
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Dapagliflozin; Metformin
  • Delafloxacin
  • Dexlansoprazole
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doxacurium
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Edetate Calcium Disodium, Calcium EDTA
  • Edetate Disodium, Disodium EDTA
  • Eltrombopag
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin; Metformin
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estramustine
  • Estrogens
  • Estropipate
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • food
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gallium
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Ibritumomab Tiuxetan
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Levofloxacin
  • Linagliptin; Metformin
  • Mestranol; Norethindrone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methyclothiazide
  • Metolazone
  • Mivacurium
  • Moxifloxacin
  • Neomycin
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Pancuronium
  • Pantoprazole
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Proton pump inhibitors
  • Rabeprazole
  • Rocuronium
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Bicarbonate
  • Sodium Fluoride
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Succinylcholine
  • Tetracyclines
  • Thiazide diuretics
  • Thyroid hormones
  • Trientine
  • Tubocurarine
  • Vecuronium
  • Vitamin A
  • Vitamin D analogs

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