Crofelemer Brand Names
FULYZAQ | Mytesi
What is Crofelemer
Crofelemer is a botanical prescription drug compound derived from the red sap of the Croton lechleri plant of Latin and South America.
It is indicated as an anti-diarrheal for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy.
Crofelemer does not affect gut motility and is not absorbed systemically to any significant level.
It instead acts locally, inhibiting the secretion of chloride ions via the cystic fibrosis transmembrane regulator (CFTR) chloride channels and the calcium-activated chloride channels (CaCC) from the luminal membrane of intestinal cells.
By blocking these channels, crofelemer reduces gastrointestinal fluid accumulation. Crofelemer received initial FDA approval in December 2012.
Indications
- diarrhea
For the symptomatic relief of non-infectious diarrhea in patients with HIV-infection/AIDS receiving anti-retroviral therapy
Side Effects
- abdominal pain
- acne vulgaris
- anxiety
- arthralgia
- back pain
- constipation
- contact dermatitis
- cough
- depression
- dizziness
- dyspepsia
- elevated hepatic enzymes
- flatulence
- hemorrhoids
- hyperbilirubinemia
- increased urinary frequency
- infection
- leukopenia
- musculoskeletal pain
- nausea
- nephrolithiasis
- pharyngitis
- sinusitis
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- Black patients
- breast-feeding
- children
- GI disease
- infants
- infection
- malabsorption syndrome
- neonates
- pancreatitis
- pregnancy
- ulcerative colitis
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Alfentanil
- Alosetron
- Anticholinergics
- Antidiarrheals
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Fentanyl
- Flavoxate
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Indacaterol; Glycopyrrolate
- Levorphanol
- Loperamide
- Loperamide; Simethicone
- Lubiprostone
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Morphine
- Morphine; Naltrexone
- Opiate Agonists
- Oxybutynin
- Oxycodone
- Oxymorphone
- Propantheline
- Propoxyphene
- Remifentanil
- Scopolamine
- Sufentanil
- Trihexyphenidyl
