Crofelemer

Crofelemer Brand Names

FULYZAQ | Mytesi

What is Crofelemer

Crofelemer is a botanical prescription drug compound derived from the red sap of the Croton lechleri plant of Latin and South America.

It is indicated as an anti-diarrheal for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy.

Crofelemer does not affect gut motility and is not absorbed systemically to any significant level.

It instead acts locally, inhibiting the secretion of chloride ions via the cystic fibrosis transmembrane regulator (CFTR) chloride channels and the calcium-activated chloride channels (CaCC) from the luminal membrane of intestinal cells.

By blocking these channels, crofelemer reduces gastrointestinal fluid accumulation. Crofelemer received initial FDA approval in December 2012.

Indications

  • diarrhea

For the symptomatic relief of non-infectious diarrhea in patients with HIV-infection/AIDS receiving anti-retroviral therapy

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. anxiety
  4. arthralgia
  5. back pain
  6. constipation
  7. contact dermatitis
  8. cough
  9. depression
  10. dizziness
  11. dyspepsia
  12. elevated hepatic enzymes
  13. flatulence
  14. hemorrhoids
  15. hyperbilirubinemia
  16. increased urinary frequency
  17. infection
  18. leukopenia
  19. musculoskeletal pain
  20. nausea
  21. nephrolithiasis
  22. pharyngitis
  23. sinusitis
  24. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • Black patients
  • breast-feeding
  • children
  • GI disease
  • infants
  • infection
  • malabsorption syndrome
  • neonates
  • pancreatitis
  • pregnancy
  • ulcerative colitis

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Alosetron
  • Anticholinergics
  • Antidiarrheals
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dicyclomine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Fentanyl
  • Flavoxate
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Indacaterol; Glycopyrrolate
  • Levorphanol
  • Loperamide
  • Loperamide; Simethicone
  • Lubiprostone
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Morphine
  • Morphine; Naltrexone
  • Opiate Agonists
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Propantheline
  • Propoxyphene
  • Remifentanil
  • Scopolamine
  • Sufentanil
  • Trihexyphenidyl
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