Cromolyn Sodium

Cromolyn Sodium Brand Names

Crolom | Gastrocrom | Intal | Nasalcrom | Opticrom

What is Cromolyn Sodium

Cromolyn is a synthetic mast cell stabilizer. Although cromolyn has no bronchodilator activity, it was found to inhibit antigen-induced bronchospasm.

The drug is used as an inhaled prophylactic agent in the treatment of mild to moderate asthma, via nasal inhalation to treat seasonal allergic rhinitis, or as an ophthalmic solution to treat allergic or vernal conjunctivitis.

The oral dosage form has limited therapeutic usage and is approved to treat systemic mastocytosis; the oral dosage form has fared no better than placebo in the treatment of inflammatory bowel disease.

Cromolyn and its many formulations are approved for use in adults and children as young as 2 years of age.

Cromolyn is considered an alternate, but not preferred, therapy to the use of inhaled corticosteroids (ICSs) in the treatment of mild persistent asthma (step 2 care) according to the 2007 guidelines of the Expert Panel of the National Asthma Education and Prevention Program.

Cromolyn is also used as a preventative for exercise-induced bronchospasm (EIB) or exposure to known allergens.

It may be used in patients with EIB who continue to have symptoms despite use of short-acting beta-2 agonists

Indications

  1. allergic conjunctivitis
  2. allergic rhinitis
  3. allergic rhinitis prophylaxis
  4. asthma
  5. exercise-induced bronchospasm prophylaxis
  6. giant papillary conjunctivitis (GPC)
  7. keratitis
  8. keratoconjunctivitis
  9. perennial allergies
  10. seasonal allergies
  11. systemic mastocytosis
  12. vernal keratoconjunctivitis

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. anemia
  4. angioedema
  5. anxiety
  6. arthralgia
  7. atrial tachycardia
  8. bronchospasm
  9. chest pain (unspecified)
  10. constipation
  11. cough
  12. depression
  13. diarrhea
  14. dizziness
  15. drowsiness
  16. dyspepsia
  17. dysphagia
  18. dyspnea
  19. dysuria
  20. edema
  21. erythema
  22. exfoliative dermatitis
  23. fatigue
  24. flatulence
  25. flushing
  26. glossitis
  27. hallucinations
  28. headache
  29. hemoptysis
  30. hoarseness
  31. hypoesthesia
  32. increased urinary frequency
  33. insomnia
  34. lacrimation
  35. laryngeal edema
  36. lethargy
  37. lupus-like symptoms
  38. malaise
  39. migraine
  40. myalgia
  41. nasal congestion
  42. nasal irritation
  43. nausea
  44. neuritis
  45. neutropenia
  46. ocular irritation
  47. ocular pruritus
  48. palpitations
  49. pancytopenia
  50. paresthesias
  51. pericarditis
  52. pharyngitis
  53. photosensitivity
  54. polycythemia
  55. premature ventricular contractions (PVCs)
  56. pruritus
  57. psychosis
  58. purpura
  59. rash
  60. seizures
  61. sneezing
  62. stomatitis
  63. throat irritation
  64. tinnitus
  65. urticaria
  66. ventricular tachycardia
  67. vertigo
  68. vomiting
  69. wheezing

Monitoring Parameters

  • laboratory monitoring not necessary
  • pulmonary function tests (PFTs)

Contraindications

  • acute bronchospasm
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • contact lenses
  • coronary artery disease
  • hepatic disease
  • infants
  • lactase deficiency
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • status asthmaticus

Interactions

There are no drug interactions associated with Cromolyn Sodium products.

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