Crizotinib

Crizotinib Brand Name– XALKORI

What is Crizotinib

Crizotinib is an oral inhibitor of receptor tyrosine kinases, including anaplastic lymphoma kinase (ALK) and ROS1.

It is indicated for the treatment of patients with metastatic non-small cell lung cancer that is ALK-positive or ROS1-positive.

Monitor ECGs and electrolytes in patients at increased risk for QT prolongation; an interruption of therapy, dose reduction, or discontinuation of therapy may be necessary.

Indications

  • non-small cell lung cancer (NSCLC)

For the treatment of non-small cell lung cancer (NSCLC)

for the treatment of patients with metastatic NSCLC that is anaplastic lymphoma kinase (ALK)- or ROS1- positive as detected by an FDA-approved test

Side Effects

  1. abdominal pain
  2. acute respiratory distress syndrome (ARDS)
  3. anorexia
  4. blurred vision
  5. bradycardia
  6. bradycardia
  7. constipation
  8. constipation
  9. diabetic ketoacidosis
  10. diarrhea
  11. diarrhea
  12. diplopia
  13. dizziness
  14. dizziness
  15. dysesthesia
  16. dysgeusia
  17. dyspepsia
  18. dysphagia
  19. dysphagia
  20. dyspnea
  21. edema
  22. edema
  23. elevated hepatic enzymes
  24. elevated hepatic enzymes
  25. esophageal ulceration
  26. esophagitis
  27. esophagitis
  28. fatigue
  29. fever
  30. gonadal suppression
  31. headache
  32. headache
  33. hepatic failure
  34. hepatotoxicity
  35. hyperbilirubinemia
  36. hypoesthesia
  37. hypokalemia
  38. hypokalemia
  39. hypophosphatemia
  40. hypophosphatemia
  41. infection
  42. interstitial lung disease
  43. interstitial lung disease
  44. laryngitis
  45. lymphopenia
  46. lymphopenia
  47. musculoskeletal pain
  48. nausea
  49. nausea
  50. neutropenia
  51. neutropenia
  52. optic atrophy
  53. optic neuritis
  54. paresthesias
  55. peripheral edema
  56. peripheral neuropathy
  57. pharyngitis
  58. photophobia
  59. photopsia
  60. pneumonitis
  61. pneumonitis
  62. pulmonary embolism
  63. QT prolongation
  64. QT prolongation
  65. rash
  66. renal failure (unspecified)
  67. rhinitis
  68. syncope
  69. syncope
  70. thrombosis
  71. thrombosis
  72. visual impairment
  73. vomiting
  74. vomiting
  75. weakness
  76. weight gain
  77. weight gain
  78. weight loss
  79. weight loss

Monitoring Parameters

  • blood pressure
  • CBC with differential
  • heart rate
  • LFTs
  • pregnancy testing

Contraindications

  • apheresis
  • AV block
  • bradycardia
  • breast-feeding
  • cardiomyopathy
  • celiac disease
  • children
  • chronic lung disease (CLD)
  • contraception requirements
  • driving or operating machinery
  • females
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • hepatotoxicity
  • human immunodeficiency virus (HIV) infection
  • hyperparathyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypothermia
  • hypothyroidism
  • infants
  • infertility
  • long QT syndrome
  • male-mediated teratogenicity
  • myocardial infarction
  • neonates
  • optic neuritis
  • pheochromocytoma
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • pulmonary disease
  • QT prolongation
  • reproductive risk
  • rheumatoid arthritis
  • sickle cell disease
  • sleep deprivation
  • stroke
  • systemic lupus erythematosus (SLE)
  • visual disturbance

Interactions

  • Abemaciclib
  • Acalabrutinib
  • Acebutolol
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Alfuzosin
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Arformoterol
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Avanafil
  • Avapritinib
  • Azithromycin
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Beta-adrenergic blockers
  • Betaxolol
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bosutinib
  • Brexpiprazole
  • Brigatinib
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Caffeine; Ergotamine
  • Cannabidiol
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  • Carteolol
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  • Chloroquine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
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  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
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  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Dofetilide
  • Dolasetron
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  • Duvelisib
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  • Eletriptan
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
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  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
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  • Granisetron
  • grapefruit juice
  • Guaifenesin; Hydrocodone
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  • Guanfacine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
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  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
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  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ketoconazole
  • Labetalol
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  • Lefamulin
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  • Levalbuterol
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  • Levofloxacin
  • Lidocaine
  • Lidocaine; Prilocaine
  • Lithium
  • Lofexidine
  • Lomitapide
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lovastatin
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
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  • Lumateperone
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  • Tamoxifen
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  • Telavancin
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  • Terbutaline
  • Tetrabenazine
  • Tezacaftor; Ivacaftor
  • Thioridazine
  • Tiagabine
  • Timolol
  • Tinidazole
  • Tiotropium; Olodaterol
  • Tipranavir
  • Tolterodine
  • Tolvaptan
  • Toremifene
  • Tramadol
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  • Trazodone
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  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimipramine
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  • Verapamil
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  • Vinorelbine
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Yohimbine
  • Zanubrutinib
  • Zileuton
  • Ziprasidone
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