Crizotinib Brand Name– XALKORI
What is Crizotinib
Crizotinib is an oral inhibitor of receptor tyrosine kinases, including anaplastic lymphoma kinase (ALK) and ROS1.
It is indicated for the treatment of patients with metastatic non-small cell lung cancer that is ALK-positive or ROS1-positive.
Monitor ECGs and electrolytes in patients at increased risk for QT prolongation; an interruption of therapy, dose reduction, or discontinuation of therapy may be necessary.
Indications
- non-small cell lung cancer (NSCLC)
For the treatment of non-small cell lung cancer (NSCLC)
for the treatment of patients with metastatic NSCLC that is anaplastic lymphoma kinase (ALK)- or ROS1- positive as detected by an FDA-approved test
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anorexia
- blurred vision
- bradycardia
- bradycardia
- constipation
- constipation
- diabetic ketoacidosis
- diarrhea
- diarrhea
- diplopia
- dizziness
- dizziness
- dysesthesia
- dysgeusia
- dyspepsia
- dysphagia
- dysphagia
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- esophageal ulceration
- esophagitis
- esophagitis
- fatigue
- fever
- gonadal suppression
- headache
- headache
- hepatic failure
- hepatotoxicity
- hyperbilirubinemia
- hypoesthesia
- hypokalemia
- hypokalemia
- hypophosphatemia
- hypophosphatemia
- infection
- interstitial lung disease
- interstitial lung disease
- laryngitis
- lymphopenia
- lymphopenia
- musculoskeletal pain
- nausea
- nausea
- neutropenia
- neutropenia
- optic atrophy
- optic neuritis
- paresthesias
- peripheral edema
- peripheral neuropathy
- pharyngitis
- photophobia
- photopsia
- pneumonitis
- pneumonitis
- pulmonary embolism
- QT prolongation
- QT prolongation
- rash
- renal failure (unspecified)
- rhinitis
- syncope
- syncope
- thrombosis
- thrombosis
- visual impairment
- vomiting
- vomiting
- weakness
- weight gain
- weight gain
- weight loss
- weight loss
Monitoring Parameters
- blood pressure
- CBC with differential
- heart rate
- LFTs
- pregnancy testing
Contraindications
- apheresis
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- children
- chronic lung disease (CLD)
- contraception requirements
- driving or operating machinery
- females
- fever
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- infertility
- long QT syndrome
- male-mediated teratogenicity
- myocardial infarction
- neonates
- optic neuritis
- pheochromocytoma
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- QT prolongation
- reproductive risk
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- visual disturbance
Interactions
- Abemaciclib
- Acalabrutinib
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apalutamide
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Beta-adrenergic blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Bosutinib
- Brexpiprazole
- Brigatinib
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Caffeine; Ergotamine
- Cannabidiol
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carteolol
- Carvedilol
- Ceritinib
- Chloramphenicol
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Cilostazol
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clonazepam
- Clonidine
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Cyclosporine
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Deutetrabenazine
- Dexamethasone
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxepin
- Doxorubicin
- Dronabinol
- Dronedarone
- Droperidol
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enflurane
- Entrectinib
- Enzalutamide
- Eplerenone
- Ergotamine
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esmolol
- Estazolam
- Ethosuximide
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Ezogabine
- Fedratinib
- Felodipine
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosphenytoin
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyzine
- Ibrutinib
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Inotuzumab Ozogamicin
- Isavuconazonium
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Labetalol
- Lapatinib
- Lefamulin
- Lemborexant
- Lenvatinib
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levofloxacin
- Lidocaine
- Lidocaine; Prilocaine
- Lithium
- Lofexidine
- Lomitapide
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macimorelin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Mephobarbital
- Metaproterenol
- Metformin; Repaglinide
- Methadone
- Metoprolol
- Metronidazole
- Midazolam
- Midostaurin
- Mifepristone
- Mirtazapine
- Mitotane
- Moxifloxacin
- Nadolol
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Niacin; Simvastatin
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olaparib
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxybutynin
- Oxycodone
- Ozanimod
- Paclitaxel
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Pemigatinib
- Penbutolol
- Pentamidine
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenobarbital
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pindolol
- Pirbuterol
- Pitolisant
- Posaconazole
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Propranolol
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Rilpivirine
- Rimegepant
- Risperidone
- Ritonavir
- Roflumilast
- Romidepsin
- Salmeterol
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Solifenacin
- Sonidegib
- Sorafenib
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamoxifen
- Tamsulosin
- Tazemetostat
- Telavancin
- Telithromycin
- Terbutaline
- Tetrabenazine
- Tezacaftor; Ivacaftor
- Thioridazine
- Tiagabine
- Timolol
- Tinidazole
- Tiotropium; Olodaterol
- Tipranavir
- Tolterodine
- Tolvaptan
- Toremifene
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Tucatinib
- Ubrogepant
- Umeclidinium; Vilanterol
- Vandetanib
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Voriconazole
- Vorinostat
- Warfarin
- Yohimbine
- Zanubrutinib
- Zileuton
- Ziprasidone
