Caffeine Ergotamine

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Caffeine Ergotamine Brand Names

Cafergot | Migergot

What is Caffeine Ergotamine

Caffeine and ergotamine are used in combination as an abortive treatment for migraine and cluster headaches.

This medication is still considered a primary treatment option by many clinicians because of its efficacy in controlling up to 70% of migraine attacks in adults and its relative cost advantage compared to other anti-migraine medications.

Prolonged use or excessive dosage of this drug combination can lead to ergotism, dependence, and/or rebound headaches. Caffeine; ergotamine should be prescribed in strict accordance with the manufacturer’s guidelines.

Maximum daily and weekly dosage limits should not be exceeded. A suppository formulation of the drug is available for those who cannot tolerate oral administration due to nausea/vomiting during migraine attacks.

Ergotamine was first used medically to treat migraines in the 1920’s, and was approved by the FDA in 1960.

Indications

  • headache
  • migraine

For the abortive treatment of acute migraine or cluster headache

Side Effects

  1. abdominal pain
  2. angina
  3. bowel ischemia
  4. bradycardia
  5. cardiac valvulopathy
  6. chest pain (unspecified)
  7. colitis
  8. coronary vasospasm
  9. diarrhea
  10. drowsiness
  11. edema
  12. fetal death
  13. headache
  14. hypertension
  15. muscle cramps
  16. myalgia
  17. myocardial infarction
  18. nausea
  19. paresthesias
  20. peripheral vasoconstriction
  21. physiological dependence
  22. polyuria
  23. pruritus
  24. pulmonary fibrosis
  25. renal tubular necrosis
  26. retroperitoneal fibrosis
  27. sinus tachycardia
  28. spontaneous fetal abortion
  29. tissue necrosis
  30. tremor
  31. urticaria
  32. uterine contractions
  33. vertigo
  34. vomiting
  35. weakness
  36. withdrawal

Monitoring Parameters

  • blood pressure
  • heart rate

Contraindications

  • angina
  • arteriosclerosis
  • basilar/hemiplegic migraine
  • biliary tract disease
  • breast-feeding
  • cardiac disease
  • children
  • cholestasis
  • coronary artery disease
  • diabetes mellitus
  • eclampsia
  • ergot alkaloid hypersensitivity
  • geriatric
  • hepatic disease
  • hypercholesterolemia
  • hypertension
  • infants
  • labor
  • myocardial infarction
  • obesity
  • obstetric delivery
  • peripheral vascular disease
  • peripheral vasoconstriction or ischemia
  • postmenopausal females
  • preeclampsia
  • pregnancy
  • pulmonary disease
  • pulmonary fibrosis
  • Raynaud’s phenomenon
  • renal disease
  • renal failure
  • renal impairment
  • retroperitoneal fibrosis
  • sepsis
  • stroke
  • surgery
  • thromboangiitis obliterans (Buerger’s disease)
  • thrombophlebitis
  • tobacco smoking
  • valvular heart disease

Interactions

  • Acebutolol
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Adenosine
  • Albuterol
  • Albuterol; Ipratropium
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Almotriptan
  • Alprazolam
  • Amantadine
  • Amiodarone
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anagrelide
  • Aprepitant, Fosaprepitant
  • Arformoterol
  • Armodafinil
  • Articaine; Epinephrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Dipyridamole
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azithromycin
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendroflumethiazide; Nadolol
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Beta-agonists
  • Beta-blockers
  • Betaxolol
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Bosentan
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide; Formoterol
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Bupropion
  • Bupropion; Naltrexone
  • Butabarbital
  • Cabergoline
  • Caffeine
  • Cannabidiol
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Carteolol
  • Carvedilol
  • Ceritinib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloroprocaine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cimetidine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Conivaptan
  • Crizotinib
  • Danazol
  • Darifenacin
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Delavirdine
  • Desloratadine; Pseudoephedrine
  • Desvenlafaxine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Diazoxide
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dipyridamole
  • Dirithromycin
  • Disulfiram
  • Dobutamine
  • Dopamine
  • Dorzolamide; Timolol
  • Dronedarone
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Echinacea
  • Elbasvir; Grazoprevir
  • Eletriptan
  • Elexacaftor; tezacaftor; ivacaftor
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emapalumab
  • Enzalutamide
  • Ephedrine
  • Epinephrine
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Esmolol
  • Eszopiclone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Everolimus
  • Fedratinib
  • Fenoldopam
  • Fesoterodine
  • Fexofenadine; Pseudoephedrine
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • Formoterol
  • Formoterol; Mometasone
  • Fostamatinib
  • Frovatriptan
  • Givosiran
  • Glycerol Phenylbutyrate
  • Glycopyrrolate; Formoterol
  • grapefruit juice
  • Green Tea
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Hydantoins
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Pseudoephedrine
  • Idelalisib
  • Imatinib
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Isavuconazonium
  • Isocarboxazid
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Istradefylline
  • Itraconazole
  • Ivacaftor
  • Ketoconazole
  • Ketoprofen
  • Labetalol
  • Lanreotide
  • Lapatinib
  • Larotrectinib
  • Lefamulin
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levomilnacipran
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Loratadine; Pseudoephedrine
  • Lorcaserin
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Mephobarbital
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mestranol; Norethindrone
  • Metaproterenol
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methylene Blue
  • Methylphenidate
  • Metoprolol
  • Metronidazole
  • Mexiletine
  • Miconazole
  • Midodrine
  • Mifepristone
  • Milnacipran
  • Minoxidil
  • Mirtazapine
  • Mitotane
  • Modafinil
  • Monoamine oxidase inhibitors
  • Nadolol
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nicardipine
  • Nicotine
  • Nilotinib
  • Nitrates
  • Nitroprusside
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Norfloxacin
  • Obeticholic Acid
  • Olodaterol
  • Oritavancin
  • Oxybutynin
  • Palbociclib
  • Paroxetine
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pemoline
  • Penbutolol
  • Pentobarbital
  • Perindopril; Amlodipine
  • Phendimetrazine
  • Phenelzine
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pindolol
  • Pirbuterol
  • Posaconazole
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Procaine
  • Procarbazine
  • Propranolol
  • Protease inhibitors
  • Pseudoephedrine
  • Quinine
  • Racepinephrine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Regadenoson
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Ritodrine
  • Rizatriptan
  • Rucaparib
  • Rufinamide
  • Salmeterol
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sibutramine
  • Simeprevir
  • Sodium Oxybate
  • Solifenacin
  • Solriamfetol
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sumatriptan
  • Suvorexant
  • Tasimelteon
  • Tedizolid
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Terbinafine
  • Terbutaline
  • Teriflunomide
  • Tezacaftor; Ivacaftor
  • Theophylline, Aminophylline
  • Thiabendazole
  • Thiopental
  • Timolol
  • Tiotropium; Olodaterol
  • tobacco
  • Tolterodine
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Umeclidinium; Vilanterol
  • Vasopressors
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Zileuton
  • Zolmitriptan
  • Zolpidem

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