Cimetidine

Cimetidine Brand Names

Acid Reducer | Major Acid Reducer | Tagamet | Tagamet HB

What is Cimetidine

Cimetidine is an oral and parenteral histamine type 2-receptor antagonist used in the treatment of various gastrointestinal (GI) disorders such as peptic ulcer and gastroesophageal reflux disease (GERD).

The actions and indications for cimetidine differ little from other H2-receptor antagonists; however, cimetidine is a known inhibitor of many of the isoenzymes of the hepatic CYP450 enzyme system.

Thus, it exhibits many clinically significant drug interactions with other medications.

Cimetidine is used mainly for treating GI disorders, although it can be beneficial for other conditions.

Over-the-counter oral formulations are available for the prophylaxis and treatment of heartburn and acid indigestion in adolescent and adult patients 12 years of age and older.

However, for the symptomatic acute and chronic treatment of GERD, proton pump inhibitors (PPIs) are considered to be more effective than H2-receptor antagonists.

Indications

1. angioedema
2. aspiration prophylaxis
3. duodenal ulcer
4. dyspepsia
5. esophagitis
6. gastric ulcer
7. gastritis
8. gastroesophageal reflux disease (GERD)
9. molluscum contagiosum
10. multiple endocrine adenoma syndrome
11. NSAID-induced ulcer prophylaxis
12. pyrosis (heartburn)
13. stress gastritis prophylaxis
14. systemic mastocytosis
15. upper GI bleeding
16. urticaria
17. verruca vulgaris
18. Zollinger-Ellison syndrome

For the treatment of gastroesophageal reflux disease (GERD) or esophagitis associated with gastroesophageal reflux disease (GERD)

Side Effects

1. agitation
2. agranulocytosis
3. alopecia
4. anaphylactoid reactions
5. anxiety
6. aplastic anemia
7. arthralgia
8. atrophic gastritis
9. AV block
10. bradycardia
11. cholestasis
12. confusion
13. depression
14. diarrhea
15. dizziness
16. drowsiness
17. elevated hepatic enzymes
18. erythema multiforme
19. exfoliative dermatitis
20. fever
21. galactorrhea
22. gynecomastia
23. hallucinations
24. headache
25. hemolytic anemia
26. hyperprolactinemia
27. hypotension
28. impotence (erectile dysfunction)
29. infection
30. interstitial nephritis
31. leukopenia
32. myalgia
33. neutropenia
34. pancreatitis
35. pancytopenia
36. pernicious anemia
37. psychosis
38. rash
39. sinus tachycardia
40. Stevens-Johnson syndrome
41. thrombocytopenia
42. toxic epidermal necrolysis
43. urinary retention
44. vasculitis
45. vitamin B12 deficiency

Monitoring Parameters

• intragastric pH
• LFTs
• serum creatinine/BUN

Contraindications

• benzyl alcohol hypersensitivity
• breast-feeding
• gastric cancer
• geriatric
• H2-blocker hypersensitivity
• hepatic disease
• immunosuppression
• infection
• intravenous administration
• neonates
• pregnancy
• renal failure
• renal impairment
• tobacco smoking
• vitamin B12 deficiency

Interactions

• Abarelix
• Acalabrutinib
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Codeine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Propoxyphene
• Acetohexamide
• Acyclovir
• Adefovir
• Albendazole
• Alendronate
• Alendronate; Cholecalciferol
• Alfentanil
• Alfuzosin
• Alogliptin; Metformin
• Alprazolam
• Altretamine
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine; Atorvastatin
• Amlodipine; Celecoxib
• Amoxapine
• Amphetamine; Dextroamphetamine Salts
• Amprenavir
• Anagrelide
• Aripiprazole
• Armodafinil
• Artemether; Lumefantrine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atazanavir
• Atazanavir; Cobicistat
• Atomoxetine
• Atorvastatin
• Atorvastatin; Ezetimibe
• Azelastine
• Azelastine; Fluticasone
• Beclomethasone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Bendamustine
• Benzhydrocodone; Acetaminophen
• Betamethasone
• Bisacodyl
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Boceprevir
• Bortezomib
• Bosutinib
• Brimonidine; Timolol
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Budesonide
• Budesonide; Formoterol
• Bupivacaine; Lidocaine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate; Risedronate
• Canagliflozin; Metformin
• Cannabidiol
• Carbamazepine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carisoprodol
• Carmustine, BCNU
• Carvedilol
• Cefditoren
• Cefpodoxime
• Ceftibuten
• Cefuroxime
• Celecoxib
• Cetrorelix
• Cevimeline
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroquine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpromazine
• Chlorpropamide
• Ciclesonide
• Cilostazol
• Cisapride
• Citalopram
• Clobazam
• Clofarabine
• Clomipramine
• Clonazepam
• Clopidogrel
• Clorazepate
• Clozapine
• Cobimetinib
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Conjugated Estrogens
• Conjugated Estrogens; Bazedoxifene
• Conjugated Estrogens; Medroxyprogesterone
• Corticosteroids
• Cortisone
• Cyclosporine
• Cysteamine
• Dacomitinib
• Dalfampridine
• Dapagliflozin; Metformin
• Darifenacin
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dasatinib
• Deflazacort
• Degarelix
• Delavirdine
• Desipramine
• Dexamethasone
• Dexmethylphenidate
• Dextromethorphan; Quinidine
• Diazepam
• Dienogest; Estradiol valerate
• Diethylstilbestrol, DES
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Naproxen
• Dirithromycin
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil; Memantine
• Dorzolamide; Timolol
• Doxepin
• Doxercalciferol
• Doxorubicin
• Dronabinol
• Dronedarone
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
• Dutasteride
• Dutasteride; Tamsulosin
• Elagolix; Estradiol; Norethindrone acetate
• Eliglustat
• Eltrombopag
• Elvitegravir
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Felodipine
• Encainide
• Entecavir
• Epirubicin
• Ergonovine
• Ergotamine
• Erlotinib
• Ertugliflozin; Metformin
• Escitalopram
• Esomeprazole; Naproxen
• Estazolam
• Esterified Estrogens
• Esterified Estrogens; Methyltestosterone
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Estradiol; Levonorgestrel
• Estradiol; Norethindrone
• Estradiol; Norgestimate
• Estradiol; Progesterone
• Estrogens
• Estropipate
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Etonogestrel
• Ezetimibe; Simvastatin
• Fedratinib
• Felodipine
• Fentanyl
• Fesoterodine
• Flecainide
• Flibanserin
• Floxuridine
• Fluconazole
• Fludrocortisone
• Flunisolide
• Fluorouracil, 5-FU
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurazepam
• Fluticasone
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvastatin
• Fluvoxamine
• Fomepizole
• food
• Formoterol; Mometasone
• Fosamprenavir
• Galantamine
• Ganirelix
• Gefitinib
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Halofantrine
• HMG-CoA reductase inhibitors
• Homatropine; Hydrocodone
• Hydantoins
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydrocortisone
• Hydroxychloroquine
• Hydroxyprogesterone
• Ibuprofen; Oxycodone
• Imatinib
• Imipramine
• Iron
• Isavuconazonium
• Isradipine
• Itraconazole
• Ivabradine
• Ketoconazole
• Labetalol
• Lamotrigine
• Lansoprazole; Naproxen
• Ledipasvir; Sofosbuvir
• Leflunomide
• Lemborexant
• Levobupivacaine
• Levomethadyl
• Lidocaine
• Lidocaine; Prilocaine
• Linagliptin; Metformin
• Lithium
• Lomefloxacin
• Lomitapide
• Lomustine, CCNU
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lovastatin
• Lovastatin; Niacin
• Lurasidone
• Maprotiline
• Maraviroc
• Mebendazole
• Mefloquine
• Melatonin
• Memantine
• Meperidine
• Meperidine; Promethazine
• Mesalamine, 5-ASA
• Mestranol; Norethindrone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methylergonovine
• Methylphenidate
• Methylprednisolone
• Methysergide
• Metoprolol
• Metronidazole
• Mexiletine
• Midazolam
• Midodrine
• Mirtazapine
• Modafinil
• Mometasone
• Moricizine
• Morphine
• Morphine; Naltrexone
• Nafarelin
• Naloxegol
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nebivolol
• Nebivolol; Valsartan
• Neratinib
• Niacin; Simvastatin
• Nicardipine
• Nifedipine
• Nilotinib
• Nimodipine
• Nisoldipine
• Nortriptyline
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Oxycodone
• Oxymorphone
• Paroxetine
• Pazopanib
• Pentoxifylline
• Perphenazine; Amitriptyline
• Pexidartinib
• Pimozide
• Pirfenidone
• Pitavastatin
• Polyethylene Glycol; Electrolytes; Bisacodyl
• Ponatinib
• Posaconazole
• Pravastatin
• Praziquantel
• Prednisolone
• Prednisone
• Procainamide
• Progesterone
• Propafenone
• Propoxyphene
• Propranolol
• Protriptyline
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Ramelteon
• Ranolazine
• Rasagiline
• Repaglinide
• Rilpivirine
• Risedronate
• Ritonavir
• Rivaroxaban
• Roflumilast
• Romidepsin
• Ropinirole
• Ropivacaine
• Rosuvastatin
• Ruxolitinib
• Saquinavir
• Secretin
• Segesterone Acetate; Ethinyl Estradiol
• Selpercatinib
• Sibutramine
• Sildenafil
• Simeprevir
• Simvastatin
• Simvastatin; Sitagliptin
• Sirolimus
• Sofosbuvir; Velpatasvir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Sonidegib
• Sufentanil
• Sulfonylureas
• Tacrine
• Tacrolimus
• Tamsulosin
• Tasimelteon
• Telaprevir
• Terbinafine
• Teriflunomide
• Thalidomide
• Theophylline, Aminophylline
• Ticlopidine
• Timolol
• Tinidazole
• Tizanidine
• Tocainide
• Tolazamide
• Tolbutamide
• Tolvaptan
• Trandolapril; Verapamil
• Tretinoin, ATRA
• Triamcinolone
• Triazolam
• Trimetrexate
• Trimipramine
• Trospium
• Ubrogepant
• Ulipristal
• Valacyclovir
• Varenicline
• Vemurafenib
• Venlafaxine
• Verapamil
• Vincristine
• Vincristine Liposomal
• Vinorelbine
• Vorapaxar
• Warfarin
• Zalcitabine, ddC
• Zaleplon
• Zolmitriptan