Cimetidine

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Cimetidine Brand Names

Acid Reducer | Major Acid Reducer | Tagamet | Tagamet HB

What is Cimetidine

Cimetidine is an oral and parenteral histamine type 2-receptor antagonist used in the treatment of various gastrointestinal (GI) disorders such as peptic ulcer and gastroesophageal reflux disease (GERD).

The actions and indications for cimetidine differ little from other H2-receptor antagonists; however, cimetidine is a known inhibitor of many of the isoenzymes of the hepatic CYP450 enzyme system.

Thus, it exhibits many clinically significant drug interactions with other medications.

Cimetidine is used mainly for treating GI disorders, although it can be beneficial for other conditions.

Over-the-counter oral formulations are available for the prophylaxis and treatment of heartburn and acid indigestion in adolescent and adult patients 12 years of age and older.

However, for the symptomatic acute and chronic treatment of GERD, proton pump inhibitors (PPIs) are considered to be more effective than H2-receptor antagonists.

Indications

  1. angioedema
  2. aspiration prophylaxis
  3. duodenal ulcer
  4. dyspepsia
  5. esophagitis
  6. gastric ulcer
  7. gastritis
  8. gastroesophageal reflux disease (GERD)
  9. molluscum contagiosum
  10. multiple endocrine adenoma syndrome
  11. NSAID-induced ulcer prophylaxis
  12. pyrosis (heartburn)
  13. stress gastritis prophylaxis
  14. systemic mastocytosis
  15. upper GI bleeding
  16. urticaria
  17. verruca vulgaris
  18. Zollinger-Ellison syndrome

For the treatment of gastroesophageal reflux disease (GERD) or esophagitis associated with gastroesophageal reflux disease (GERD)

Side Effects

  1. agitation
  2. agranulocytosis
  3. alopecia
  4. anaphylactoid reactions
  5. anxiety
  6. aplastic anemia
  7. arthralgia
  8. atrophic gastritis
  9. AV block
  10. bradycardia
  11. cholestasis
  12. confusion
  13. depression
  14. diarrhea
  15. dizziness
  16. drowsiness
  17. elevated hepatic enzymes
  18. erythema multiforme
  19. exfoliative dermatitis
  20. fever
  21. galactorrhea
  22. gynecomastia
  23. hallucinations
  24. headache
  25. hemolytic anemia
  26. hyperprolactinemia
  27. hypotension
  28. impotence (erectile dysfunction)
  29. infection
  30. interstitial nephritis
  31. leukopenia
  32. myalgia
  33. neutropenia
  34. pancreatitis
  35. pancytopenia
  36. pernicious anemia
  37. psychosis
  38. rash
  39. sinus tachycardia
  40. Stevens-Johnson syndrome
  41. thrombocytopenia
  42. toxic epidermal necrolysis
  43. urinary retention
  44. vasculitis
  45. vitamin B12 deficiency

Monitoring Parameters

  • intragastric pH
  • LFTs
  • serum creatinine/BUN

Contraindications

  • benzyl alcohol hypersensitivity
  • breast-feeding
  • gastric cancer
  • geriatric
  • H2-blocker hypersensitivity
  • hepatic disease
  • immunosuppression
  • infection
  • intravenous administration
  • neonates
  • pregnancy
  • renal failure
  • renal impairment
  • tobacco smoking
  • vitamin B12 deficiency

Interactions

  • Abarelix
  • Acalabrutinib
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetohexamide
  • Acyclovir
  • Adefovir
  • Albendazole
  • Alendronate
  • Alendronate; Cholecalciferol
  • Alfentanil
  • Alfuzosin
  • Alogliptin; Metformin
  • Alprazolam
  • Altretamine
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Atorvastatin
  • Amlodipine; Celecoxib
  • Amoxapine
  • Amphetamine; Dextroamphetamine Salts
  • Amprenavir
  • Anagrelide
  • Aripiprazole
  • Armodafinil
  • Artemether; Lumefantrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Azelastine
  • Azelastine; Fluticasone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendamustine
  • Benzhydrocodone; Acetaminophen
  • Betamethasone
  • Bisacodyl
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Boceprevir
  • Bortezomib
  • Bosutinib
  • Brimonidine; Timolol
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate; Risedronate
  • Canagliflozin; Metformin
  • Cannabidiol
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Carmustine, BCNU
  • Carvedilol
  • Cefditoren
  • Cefpodoxime
  • Ceftibuten
  • Cefuroxime
  • Celecoxib
  • Cetrorelix
  • Cevimeline
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorpropamide
  • Ciclesonide
  • Cilostazol
  • Cisapride
  • Citalopram
  • Clobazam
  • Clofarabine
  • Clomipramine
  • Clonazepam
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Cobimetinib
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Cysteamine
  • Dacomitinib
  • Dalfampridine
  • Dapagliflozin; Metformin
  • Darifenacin
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Deflazacort
  • Degarelix
  • Delavirdine
  • Desipramine
  • Dexamethasone
  • Dexmethylphenidate
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Naproxen
  • Dirithromycin
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil; Memantine
  • Dorzolamide; Timolol
  • Doxepin
  • Doxercalciferol
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dutasteride
  • Dutasteride; Tamsulosin
  • Elagolix; Estradiol; Norethindrone acetate
  • Eliglustat
  • Eltrombopag
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Encainide
  • Entecavir
  • Epirubicin
  • Ergonovine
  • Ergotamine
  • Erlotinib
  • Ertugliflozin; Metformin
  • Escitalopram
  • Esomeprazole; Naproxen
  • Estazolam
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etonogestrel
  • Ezetimibe; Simvastatin
  • Fedratinib
  • Felodipine
  • Fentanyl
  • Fesoterodine
  • Flecainide
  • Flibanserin
  • Floxuridine
  • Fluconazole
  • Fludrocortisone
  • Flunisolide
  • Fluorouracil, 5-FU
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvastatin
  • Fluvoxamine
  • Fomepizole
  • food
  • Formoterol; Mometasone
  • Fosamprenavir
  • Galantamine
  • Ganirelix
  • Gefitinib
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halofantrine
  • HMG-CoA reductase inhibitors
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydroxychloroquine
  • Hydroxyprogesterone
  • Ibuprofen; Oxycodone
  • Imatinib
  • Imipramine
  • Iron
  • Isavuconazonium
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ketoconazole
  • Labetalol
  • Lamotrigine
  • Lansoprazole; Naproxen
  • Ledipasvir; Sofosbuvir
  • Leflunomide
  • Lemborexant
  • Levobupivacaine
  • Levomethadyl
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linagliptin; Metformin
  • Lithium
  • Lomefloxacin
  • Lomitapide
  • Lomustine, CCNU
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lovastatin
  • Lovastatin; Niacin
  • Lurasidone
  • Maprotiline
  • Maraviroc
  • Mebendazole
  • Mefloquine
  • Melatonin
  • Memantine
  • Meperidine
  • Meperidine; Promethazine
  • Mesalamine, 5-ASA
  • Mestranol; Norethindrone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methylergonovine
  • Methylphenidate
  • Methylprednisolone
  • Methysergide
  • Metoprolol
  • Metronidazole
  • Mexiletine
  • Midazolam
  • Midodrine
  • Mirtazapine
  • Modafinil
  • Mometasone
  • Moricizine
  • Morphine
  • Morphine; Naltrexone
  • Nafarelin
  • Naloxegol
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol
  • Nebivolol; Valsartan
  • Neratinib
  • Niacin; Simvastatin
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nisoldipine
  • Nortriptyline
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oxycodone
  • Oxymorphone
  • Paroxetine
  • Pazopanib
  • Pentoxifylline
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Pimozide
  • Pirfenidone
  • Pitavastatin
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Ponatinib
  • Posaconazole
  • Pravastatin
  • Praziquantel
  • Prednisolone
  • Prednisone
  • Procainamide
  • Progesterone
  • Propafenone
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Repaglinide
  • Rilpivirine
  • Risedronate
  • Ritonavir
  • Rivaroxaban
  • Roflumilast
  • Romidepsin
  • Ropinirole
  • Ropivacaine
  • Rosuvastatin
  • Ruxolitinib
  • Saquinavir
  • Secretin
  • Segesterone Acetate; Ethinyl Estradiol
  • Selpercatinib
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sirolimus
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sonidegib
  • Sufentanil
  • Sulfonylureas
  • Tacrine
  • Tacrolimus
  • Tamsulosin
  • Tasimelteon
  • Telaprevir
  • Terbinafine
  • Teriflunomide
  • Thalidomide
  • Theophylline, Aminophylline
  • Ticlopidine
  • Timolol
  • Tinidazole
  • Tizanidine
  • Tocainide
  • Tolazamide
  • Tolbutamide
  • Tolvaptan
  • Trandolapril; Verapamil
  • Tretinoin, ATRA
  • Triamcinolone
  • Triazolam
  • Trimetrexate
  • Trimipramine
  • Trospium
  • Ubrogepant
  • Ulipristal
  • Valacyclovir
  • Varenicline
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
  • Vorapaxar
  • Warfarin
  • Zalcitabine, ddC
  • Zaleplon
  • Zolmitriptan

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