Cinacalcet

Cinacalcet Brand Name– Sensipar

What is Cinacalcet

Cinacalcet is an oral calcimimetic agent, and represents the first approved agent within this drug class.

It is indicated for the treatment of patients with secondary hyperparathyroidism due to chronic kidney disease, in patients with hypercalcemia associated with parathyroid carcinoma, and in patients with severe hypercalcemia due to primary hyperparathyroidism who are unable to undergo parathyroidectomy.

Cinacalcet directly reduces parathyroid hormone (PTH) while lowering the calcium-phosphorus product.

This action is consistent with the National Kidney Foundation Disease Outcomes Quality Initiative (K/DOQI) clinical practice guidelines for bone metabolism and disease in chronic kidney disease.

In a clinical trial, cinacalcet was shown to reduce high serum calcium levels in patients with parathyroid carcinoma (manufacturer data).

With nearly 500 patients developing this rare condition annually, cinacalcet was granted orphan designation by the FDA.

Cinacalcet was originally approved by the FDA in March 2004.

Indications

  1. hypercalcemia
  2. hyperparathyroidism

For the treatment of hypercalcemia in patients with parathyroid carcinoma

Side Effects

  1. anemia
  2. angioedema
  3. anorexia
  4. arrhythmia exacerbation
  5. arthralgia
  6. asthenia
  7. bone fractures
  8. chest pain (unspecified)
  9. constipation
  10. dehydration
  11. depression
  12. diarrhea
  13. dizziness
  14. fatigue
  15. GI bleeding
  16. headache
  17. heart failure
  18. hypercalcemia
  19. hypertension
  20. hypocalcemia
  21. hypotension
  22. infection
  23. myalgia
  24. nausea
  25. osteodystrophy
  26. paresthesias
  27. QT prolongation
  28. rash
  29. seizures
  30. urticaria
  31. vomiting

Monitoring Parameters

  • blood pressure
  • heart rate
  • serum calcium
  • serum intact parathyroid hormone concentrations (iPTH)
  • serum phosphate

Contraindications

  • breast-feeding
  • children
  • esophagitis
  • gastritis
  • heart failure
  • hepatic disease
  • hypocalcemia
  • infants
  • long QT syndrome
  • neonates
  • peptic ulcer disease
  • pregnancy
  • seizure disorder
  • vomiting

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Tramadol
  • Amiodarone
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamines
  • Anagrelide
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Artemether; Lumefantrine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Barbiturates
  • Boceprevir
  • Bosentan
  • Brexpiprazole
  • Brimonidine; Timolol
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Carbamazepine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carvedilol
  • Ceritinib
  • Cevimeline
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Clarithromycin
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Denosumab
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Donepezil
  • Donepezil; Memantine
  • Dorzolamide; Timolol
  • Doxercalciferol
  • Doxorubicin
  • Dronedarone
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Encainide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Etelcalcetide
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fosphenytoin
  • Gefitinib
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Idelalisib
  • Iloperidone
  • Isavuconazonium
  • Itraconazole
  • Ketoconazole
  • Letermovir
  • Lofexidine
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Maprotiline
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Metoclopramide
  • Metoprolol
  • Mexiletine
  • Mirabegron
  • Mitotane
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nevirapine
  • Obeticholic Acid
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Paroxetine
  • Pazopanib
  • Peginterferon Alfa-2b
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenytoin
  • Pimozide
  • Pitolisant
  • Posaconazole
  • Propafenone
  • Propranolol
  • Ranolazine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifamycins
  • Risperidone
  • Ritonavir
  • Rolapitant
  • Simeprevir
  • St. John’s Wort, Hypericum perforatum
  • Tamoxifen
  • Tamsulosin
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Teriflunomide
  • Thioridazine
  • Timolol
  • Tramadol
  • Trandolapril; Verapamil
  • Tricyclic antidepressants
  • Tucatinib
  • Valbenazine
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Voriconazole
  • Vortioxetine
  • Zafirlukast
  • Zileuton
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