Armodafinil

Armodafinil Brand Name– Nuvigil

What is Armodafinil

Armodafinil is a psychostimulant and the R-enantiomer of the racemic compound modafinil.

Safety and effectiveness of the drug were based on positive results of double-blind, randomized, placebo-controlled studies in patients with excessive sleepiness associated with narcolepsy, shift-work sleep disorder (SWSD), and obstructive sleep apnea/hypopnea syndrome (OSA/HS).

The clinical trial data suggest that patients treated with armodafinil had a significant improvement in the primary endpoints including objective sleep latency and the physician rating of Clinical Global Impression-Change.

The trials also showed that armodafinil promotes wakefulness later in the day without impairing sleep, thus establishing that it has a long duration of action.

Armodafinil (Nuvigil) received FDA approval in June 2007 for excessive sleepiness associated with narcolepsy and shift-work sleep disorder, and as an adjunct to standard treatment for OSA/HS.

Indications

  • narcolepsy
  • obstructive sleep apnea
  • shift work sleep disorder

For the treatment of narcolepsy to improve wakefulness in patients with excessive sleepiness

Side Effects

  1. abdominal pain
  2. agitation
  3. angioedema
  4. anorexia
  5. anxiety
  6. bronchospasm
  7. constipation
  8. contact dermatitis
  9. depression
  10. diarrhea
  11. dizziness
  12. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  13. dyspepsia
  14. dyspnea
  15. elevated hepatic enzymes
  16. fatigue
  17. fever
  18. hallucinations
  19. headache
  20. hyperhidrosis
  21. hypertension
  22. influenza
  23. insomnia
  24. mania
  25. migraine
  26. nausea
  27. oral ulceration
  28. palpitations
  29. pancytopenia
  30. paresthesias
  31. physiological dependence
  32. polyuria
  33. psychological dependence
  34. rash
  35. restlessness
  36. Stevens-Johnson syndrome
  37. suicidal ideation
  38. tolerance
  39. toxic epidermal necrolysis
  40. tremor
  41. vomiting
  42. withdrawal
  43. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • alcoholism
  • angina
  • angioedema
  • bipolar disorder
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • contraception requirements
  • depression
  • driving or operating machinery
  • geriatric
  • heart failure
  • hepatic disease
  • hepatitis
  • hypertension
  • infants
  • mania
  • myocardial infarction
  • neonates
  • neurological disease
  • pregnancy
  • psychosis
  • renal disease
  • renal failure
  • renal impairment
  • schizophrenia
  • serious rash
  • substance abuse
  • suicidal ideation
  • valvular heart disease
  • ventricular dysfunction

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Artemether; Lumefantrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Barbiturates
  • Bedaquiline
  • Benzhydrocodone; Acetaminophen
  • Benzphetamine
  • Brexpiprazole
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine
  • Caffeine; Ergotamine
  • Cannabidiol
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Carvedilol
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cimetidine
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clomipramine
  • Clopidogrel
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Conivaptan
  • Cyclosporine
  • Daclatasvir
  • Dapsone
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dexamethasone
  • Dexmethylphenidate
  • Dextroamphetamine
  • Diazepam
  • Dienogest; Estradiol valerate
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Dronabinol
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Erlotinib
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fosamprenavir
  • Fosphenytoin
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen; Oxycodone
  • Isavuconazonium
  • Isocarboxazid
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Linezolid
  • Lisdexamfetamine
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lumateperone
  • Macimorelin
  • Maraviroc
  • Mestranol; Norethindrone
  • Methamphetamine
  • Methylphenidate
  • Midazolam
  • Monoamine oxidase inhibitors
  • Nanoparticle Albumin-Bound Paclitaxel
  • Nefazodone
  • Nisoldipine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oxycodone
  • Pemoline
  • Perampanel
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenytoin
  • Praziquantel
  • Procarbazine
  • Progestins
  • Propranolol
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rilpivirine
  • Ritonavir
  • Rivaroxaban
  • Sapropterin
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Simeprevir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solriamfetol
  • Sonidegib
  • Sufentanil
  • Tasimelteon
  • Terbinafine
  • Theophylline, Aminophylline
  • Tranylcypromine
  • Triazolam
  • Ubrogepant
  • Ulipristal
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Voriconazole
  • Warfarin
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