Armodafinil Brand Name– Nuvigil
What is Armodafinil
Armodafinil is a psychostimulant and the R-enantiomer of the racemic compound modafinil.
Safety and effectiveness of the drug were based on positive results of double-blind, randomized, placebo-controlled studies in patients with excessive sleepiness associated with narcolepsy, shift-work sleep disorder (SWSD), and obstructive sleep apnea/hypopnea syndrome (OSA/HS).
The clinical trial data suggest that patients treated with armodafinil had a significant improvement in the primary endpoints including objective sleep latency and the physician rating of Clinical Global Impression-Change.
The trials also showed that armodafinil promotes wakefulness later in the day without impairing sleep, thus establishing that it has a long duration of action.
Armodafinil (Nuvigil) received FDA approval in June 2007 for excessive sleepiness associated with narcolepsy and shift-work sleep disorder, and as an adjunct to standard treatment for OSA/HS.
Indications
- narcolepsy
- obstructive sleep apnea
- shift work sleep disorder
For the treatment of narcolepsy to improve wakefulness in patients with excessive sleepiness
Side Effects
- abdominal pain
- agitation
- angioedema
- anorexia
- anxiety
- bronchospasm
- constipation
- contact dermatitis
- depression
- diarrhea
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- fatigue
- fever
- hallucinations
- headache
- hyperhidrosis
- hypertension
- influenza
- insomnia
- mania
- migraine
- nausea
- oral ulceration
- palpitations
- pancytopenia
- paresthesias
- physiological dependence
- polyuria
- psychological dependence
- rash
- restlessness
- Stevens-Johnson syndrome
- suicidal ideation
- tolerance
- toxic epidermal necrolysis
- tremor
- vomiting
- withdrawal
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- abrupt discontinuation
- acute myocardial infarction
- alcoholism
- angina
- angioedema
- bipolar disorder
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- contraception requirements
- depression
- driving or operating machinery
- geriatric
- heart failure
- hepatic disease
- hepatitis
- hypertension
- infants
- mania
- myocardial infarction
- neonates
- neurological disease
- pregnancy
- psychosis
- renal disease
- renal failure
- renal impairment
- schizophrenia
- serious rash
- substance abuse
- suicidal ideation
- valvular heart disease
- ventricular dysfunction
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
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- Bedaquiline
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- Benzphetamine
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- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cimetidine
- Citalopram
- Clarithromycin
- Clobazam
- Clomipramine
- Clopidogrel
- Clozapine
- Cobicistat
- Cobimetinib
- Conivaptan
- Cyclosporine
- Daclatasvir
- Dapsone
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dexamethasone
- Dexmethylphenidate
- Dextroamphetamine
- Diazepam
- Dienogest; Estradiol valerate
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dronabinol
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
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- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fosamprenavir
- Fosphenytoin
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Oxycodone
- Isavuconazonium
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- Ubrogepant
- Ulipristal
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Warfarin
