Chlorpheniramine Guaifenesin Hydrocodone Pseudoephedrine

Chlorpheniramine Guaifenesin Hydrocodone Pseudoephedrine Brand Name– DroTuss | ZTuss Expectorant

What is Chlorpheniramine Guaifenesin Hydrocodone Pseudoephedrine

Chlorpheniramine guaifenesin hydrocodone pseudoephedrine are used together in an oral preparation to relieve cough, congestion, and other symptoms due to colds, acute respiratory infections, acute and chronic bronchitis, and allergies.

Chlorpheniramine is a sedating antihistamine of the alkylamine class that dries the nasal and sinus passages.

Guaifenesin loosens and thins phlegm and bronchial secretions to ease expectoration and is especially useful in the treatment of dry, non-productive coughs.

Hydrocodone is a semisynthetic opiate agonist that is included for its antitussive effects.

Pseudoephedrine is a sympathomimetic agent that relieves nasal and sinus congestion.

Indications

  1. allergic rhinitis
  2. bronchitis
  3. common cold
  4. cough
  5. nasal congestion

For the treatment of nasal congestion and cough, especially non-productive cough, due to the common cold, acute respiratory infections, acute and chronic bronchitis, allergic rhinitis, and hay fever

Adverse Reactions

  • abdominal pain
  • angina
  • anxiety
  • arrhythmia exacerbation
  • blurred vision
  • confusion
  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • dysphoria
  • dysuria
  • emotional lability
  • euphoria
  • headache
  • hypotension
  • impaired cognition
  • insomnia
  • lethargy
  • myocardial infarction
  • nausea
  • nephrolithiasis
  • palpitations
  • photophobia
  • premature ventricular contractions (PVCs)
  • pruritus
  • psychological dependence
  • rash
  • respiratory depression
  • sinus tachycardia
  • stroke
  • supraventricular tachycardia (SVT)
  • tolerance
  • urinary retention
  • urticaria
  • vomiting
  • weakness
  • withdrawal
  • xerophthalmia
  • xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • angina
  • asthma
  • bladder obstruction
  • breast-feeding
  • bronchitis
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • constipation
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • diarrhea
  • driving or operating machinery
  • emphysema
  • geriatric
  • GI obstruction
  • head trauma
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intracranial pressure
  • infants
  • labor
  • MAOI therapy
  • myocardial infarction
  • neonates
  • opiate agonist hypersensitivity
  • peptic ulcer disease
  • pregnancy
  • prostatic hypertrophy
  • renal impairment
  • substance abuse
  • tachycardia
  • tobacco smoking
  • ulcerative colitis
  • urinary retention

Interactions

  • Abiraterone
  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alkalinizing Agents
  • Almotriptan
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Alvimopan
  • Amantadine
  • Ambenonium Chloride
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  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
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  • Brompheniramine; Pseudoephedrine
  • Budesonide; Formoterol
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  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate
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  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
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  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Cariprazine
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Castor Oil
  • Celecoxib
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chloramphenicol
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroprocaine
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clevidipine
  • Clobazam
  • Clonazepam
  • Clonidine
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Conivaptan
  • Crizotinib
  • Crofelemer
  • Cyclizine
  • Cyclobenzaprine
  • Cyclosporine
  • Cyproheptadine
  • Dabrafenib
  • Dacomitinib
  • Dalfopristin; Quinupristin
  • Danazol
  • Dantrolene
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  • Dapagliflozin; Metformin
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  • Daratumumab; Hyaluronidase
  • Darifenacin
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  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Delavirdine
  • Desflurane
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexpanthenol
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dicyclomine
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Dolasetron
  • Donepezil
  • Donepezil; Memantine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxorubicin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Droxidopa
  • Dulaglutide
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eletriptan
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  • Eltrombopag
  • Eluxadoline
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  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Enzalutamide
  • Ephedrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Eslicarbazepine
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Etomidate
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  • Felodipine
  • Fentanyl
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  • Flavoxate
  • Flibanserin
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Flutamide
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • Formoterol
  • Formoterol; Mometasone
  • Fosamprenavir
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
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  • Frovatriptan
  • Furosemide
  • Gabapentin
  • Galantamine
  • General anesthetics
  • Gentamicin
  • Ginger, Zingiber officinale
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Granisetron
  • grapefruit juice
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Guanfacine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
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  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Riociguat
  • Risperidone
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Rizatriptan
  • Rolapitant
  • Ropinirole
  • Ropivacaine
  • Rosiglitazone
  • Rotigotine
  • Rucaparib
  • Safinamide
  • Salmeterol
  • Saquinavir
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Selexipag
  • Selpercatinib
  • Semaglutide
  • Serotonin-Receptor Agonists
  • Serotonin-Receptor Antagonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Iodide
  • Sodium Oxybate
  • Solifenacin
  • Solriamfetol
  • Sorbitol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Streptomycin
  • Sufentanil
  • Sulfonylureas
  • Sumatriptan
  • Suvorexant
  • Tacrine
  • Tamsulosin
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Terbinafine
  • Terbutaline
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Ticagrelor
  • Timolol
  • Tipranavir
  • Tizanidine
  • Tobramycin
  • Tolcapone
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Triprolidine
  • Trospium
  • Tucatinib
  • Umeclidinium; Vilanterol
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vasodilators
  • Vasopressors
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
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